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Recent Publications (updated May 30, 2015)

These are recent papers that have been published by individual PGRN groups.


Click on the month to go to the list of publications for that particular month and year.

Publications from 2015

July 2015Back to top

Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action.

Sun J, Zhao M, Jia P, Wang L, Wu Y, Iverson C, Zhou Y, Bowton E, Roden DM, Denny JC, Aldrich MC, Xu H, Zhao Z.
PLoS Comput Biol. 2015 Jun 17;11(6) doi: 10.1371/journal.pcbi.1004202. Epub ahead of print
PMID: 26083494

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.
Trynka G, Westra HJ, Slowikowski K, Hu X, Xu H, Stranger BE, Klein RJ, Han B, Raychaudhuri S.
Am J Hum Genet. 2015 Jul 2;97(1):139-152. doi: 10.1016/j.ajhg.2015.05.016.
PMID: 26140449

Genome-wide association studies for taxane-induced peripheral neuropathy (TIPN) in ECOG-5103 and ECOG-1199.

Schneider BP, Li L, Radovich M, Shen F, Miller C, Flockhart DA, Jiang G, Vance GH, Gardner L, Vatta M, Bai C, Lai D, Koller D, Zhao F, O'Neill A, Smith ML, Railey E, White C, Patridge A, Sparano JA, Davidson NE, Foroud T, Sledge GW.
Clin Cancer Res. 2015 Jul 2. pii: clincanres.0586.2015. Epub ahead of print
PMID: 26138065

Relating Essential Proteins To Drug Side-Effects Using Canonical Component Analysis: A Structure-Based Approach.

Liu T, Altman RB.
J Chem Inf Model. 2015 Jun 29. Epub ahead of print
PMID: 26121262

Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers.

Chenoweth MJ, Novalen M, Hawk LW Jr, Schnoll RA, George TP, Cinciripini PM, Lerman C, Tyndale RF.
Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1773-82. doi: 10.1158/1055-9965.EPI-14-0427. Epub ahead of print
PMID: 25012994

Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study.

Pui CH, Pei D, Coustan-Smith E, Jeha S, Cheng C, Bowman WP, Sandlund JT, Ribeiro RC, Rubnitz JE, Inaba H, Bhojwani D, Gruber TA, Leung WH, Downing JR, Evans WE, Relling MV, Campana D.
Lancet Oncol. 2015 Apr;16(4):465-74. doi: 10.1016/S1470-2045(15)70082-3. Epub 2015 Mar 20. Epub
PMID: 25800893


June 2015Back to top

A test of genetic models for the evolutionary maintenance of same-sex sexual behaviour.
Hoskins JL, Ritchie MG, Bailey NW.
Proc Biol Sci. 2015 Jun 22;282(1809). pii: 20150429. doi: 10.1098/rspb.2015.0429.
PMID: 26019160


May 2015Back to top
 

The FDA and Genomic Tests - Getting Regulation Right.
Evans BJ, Burke W, Jarvik GP.
N Engl J Med. 2015 May 27. Epub ahead of print
PMID: 26014592

Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network.
Hall MA, Verma SS, Wallace J, Lucas A, Berg RL, Connolly J, Crawford DC, Crosslin DR, de Andrade M, Doheny KF, Haines JL, Harley JB, Jarvik GP, Kitchner T, Kuivaniemi H, Larson EB, Carrell DS, Tromp G, Vrabec TR, Pendergrass SA, McCarty CA, Ritchie MD.
Genet Epidemiol. 2015 May 17. doi: 10.1002/gepi.21902. Epub ahead of print
PMID: 25982363

Comprehensively Evaluating cis-Regulatory Variation in the Human Prostate Transcriptome by Using Gene-Level Allele-Specific Expression.
Larson NB, McDonnell S, French AJ, Fogarty Z, Cheville J, Middha S, Riska S, Baheti S, Nair AA, Wang L, Schaid DJ, Thibodeau SN.
Am J Hum Genet. 2015 May 13. pii: S0002-9297(15)00152-4. doi: 10.1016/j.ajhg.2015.04.015. Epub ahead of print
PMID: 25983244

"Target-Site" Drug Metabolism and Transport.
Foti RS, Tyndale RF, Garcia KL, Sweet DH, Nagar S, Sharan S, Rock DA.
Drug Metab Dispos. 2015 May 18. pii: dmd.115.064576. Epub ahead of print
PMID: 25986849

Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.
Fernandez CA, Smith C, Yang W, Mullighan CG, Qu C, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Karol SE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV.
Blood. 2015 May 18. pii: blood-2015-02-628800. Epub ahead of print
PMID: 25987655

Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?
Scott IC, Rijsdijk F, Walker J, Quist J, Spain SL, Tan R, Steer S, Okada Y, Raychaudhuri S, Cope AP, Lewis CM.
J Rheumatol. 2015 May 15. pii: jrheum.141211. Epub ahead of print
PMID: 25979711

Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics.
Breitenstein MK, Simon G, Ryu E, Armasu SM, Weinshilboum RM, Wang L, Pathak J.
Stud Health Technol Inform. 2015;210:914-8.
PMID: 25991289

Inherited genetic variation in childhood acute lymphoblastic leukemia.
Moriyama T, Relling MV, Yang JJ.
Blood. 2015 May 21. pii: blood-2014-12-580001. Epub ahead of print
PMID: 25999454

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.
Franke L, El Bannoudi H, Jansen DT, Kok K, Trynka G, Diogo D, Swertz M, Fransen K, Knevel R, Gutierrez-Achury J, Ärlestig L, Greenberg JD, Kremer J, Pappas DA, Kanterakis A, Weersma RK, van der Helm-van Mil AH, Guryev V, Rantapää-Dahlqvist S, Gregersen PK, Plenge RM, Wijmenga C, Huizinga TW, Ioan-Facsinay A, Toes RE, Zhernakova A.
Eur J Hum Genet. 2015 May 13. doi: 10.1038/ejhg.2015.95. Epub ahead of print
PMID: 25966632

PharmGKB summary: Efavirenz pathway, pharmacokinetics.
McDonagh EM, Lau JL, Alvarellos ML, Altman RB, Klein TE.
Pharmacogenet Genomics. 2015 May 8. Epub ahead of print No abstract available.
PMID: 25966836

Identification and mechanistic investigation of drug-drug interactions associated with myopathy - A translational approach.
Han X, Quinney SK, Wang Z, Zhang P, Duke J, Desta Z, Elmendorf JS, Flockhart DA, Li L.
Clin Pharmacol Ther. 2015 May 14. doi: 10.1002/cpt.150. Epub ahead of print
PMID: 25975815

Variation in genes controlling warfarin disposition and response in American Indian and Alaska Native people: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX.
Fohner AE, Robinson R, Yracheta J, Dillard DA, Schilling B, Khan B, Hopkins S, Boyer BB, Black J, Wiener H, Tiwari HK, Gordon A, Nickerson D, Tsai JM, Farin FM, Thornton TA, Rettie AE, Thummel KE.
Pharmacogenet Genomics. 2015 May 4. Epub ahead of print
PMID: 25946405


April 2015Back to top

Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.
Sordillo JE, Kelly R, Bunyavanich S, McGeachie M, Qiu W, Croteau-Chonka DC, Soto-Quiros M, Avila L, Celedón JC, Brehm JM, Weiss ST, Gold DR, Litonjua AA.
J Allergy Clin Immunol. 2015 Apr 24. pii: S0091-6749(15)00341-3. doi: 10.1016/j.jaci.2015.02.035 Epub ahead of print
PMID: 25913104

Plasma genetic and genomic abnormalities predict treatment response and clinical outcome in advanced prostate cancer.
Xia S, Kohli M, Du M, Dittmar RL, Lee A, Nandy D, Yuan T, Guo Y, Wang Y, Tschannen MR, Worthey E, Jacob H, See W, Kilari D, Wang X, Hovey RL, Huang CC, Wang L.
Oncotarget. 2015 Apr 15. Epub ahead of print
PMID: 25915538

Pharmacogenomic assessment of Mexican and Peruvian populations.
Marsh S, King CR, Van Booven DJ, Revollo JY, Gilman RH, McLeod HL.
Pharmacogenomics. 2015 Apr;16(5):441-8. doi: 10.2217/pgs.15.10.
PMID: 25916516

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.
Gutierrez-Achury J, Zhernakova A, Pulit SL, Trynka G, Hunt KA, Romanos J, Raychaudhuri S, van Heel DA, Wijmenga C, de Bakker PI.
Nat Genet. 2015 Apr 20. doi: 10.1038/ng.3268. Epub ahead of print
PMID: 25894500

A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand.
Zhang R, Yao J, Xu P, Ji B, Luck JV, Chin B, Lu S, Kelsoe JR, Ma J.
Inflamm Res. 2015 Apr 17. Epub ahead of print
PMID: 25894512

The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.
Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R.
Transl Psychiatry. 2015 Apr 21;5:e553. doi: 10.1038/tp.2015.47.
PMID: 25897834

Neurotoxicity of generic anesthesia agents in infants and children: an orphan research question in search of a sponsor.
Psaty BM, Platt R, Altman RB.
JAMA. 2015 Apr 21;313(15):1515-6. doi: 10.1001/jama.2015.1149. No abstract available.
PMID: 25898045

A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians.
Shim H, Chasman DI, Smith JD, Mora S, Ridker PM, Nickerson DA, Krauss RM, Stephens M.
PLoS One. 2015 Apr 21;10(4):e0120758. doi: 10.1371/journal.pone.0120758. eCollection 2015.
PMID: 25898129

Community dissemination and genetic research: Moving beyond results reporting.
Trinidad SB, Ludman EJ, Hopkins S, James RD, Hoeft TJ, Kinegak A, Lupie H, Kinegak R, Boyer BB, Burke W.
Am J Med Genet A. 2015 Apr 21. doi: 10.1002/ajmg.a.37028. Epub ahead of print
PMID: 25900516

Performant Mutation Identification using Targeted Next Generation Sequencing of Fourteen Thoracic Aortic Aneurysm Genes.
Proost D, Vandeweyer G, Meester JA, Salemink S, Kempers M, Ingram C, Peeters N, Saenen J, Vrints C, Lacro RV, Roden D, Wuyts W, Dietz HC, Mortier G, Loeys BL, Van Laer L.
Hum Mutat. 2015 Apr 23. doi: 10.1002/humu.22802. Epub ahead of print
PMID: 25907466

Alcohol misuse, genetics, and major bleeding among warfarin therapy patients in a community setting.
Roth JA, Bradley K, Thummel KE, Veenstra DL, Boudreau D.
Pharmacoepidemiol Drug Saf. 2015 Apr 8. doi: 10.1002/pds.3769. Epub ahead of print
PMID: 25858232

The dutch hypothesis meets genomics.
Weiss ST.
Am J Respir Crit Care Med. 2015 Apr 1;191(7):722-3. doi: 10.1164/rccm.201501-0178ED. No abstract available.
PMID: 25830514

Design, implementation, and first-year outcomes of a value-based drug formulary.
Sullivan SD, Yeung K, Vogeler C, Ramsey SD, Wong E, Murphy CO, Danielson D, Veenstra DL, Garrison LP, Burke W, Watkins JB.
J Manag Care Spec Pharm. 2015 Apr;21(4):269-75.
PMID: 25803760


March 2015Back to top

High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
Kim K, Bang SY, Lee HS, Cho SK, Choi CB, Sung YK, Kim TH, Jun JB, Yoo DH, Kang YM, Kim SK, Suh CH, Shim SC, Lee SS, Lee J, Chung WT, Choe JY, Shin HD, Lee JY, Han BG, Nath SK, Eyre S, Bowes J, Pappas DA, Kremer JM, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Ärlestig L, Okada Y, Diogo D, Liao KP, Karlson EW, Raychaudhuri S, Rantapää-Dahlqvist S, Martin J, Klareskog L, Padyukov L, Gregersen PK, Worthington J, Greenberg JD, Plenge RM, Bae SC.
Ann Rheum Dis. 2015 Mar;74(3):e13. doi: 10.1136/annrheumdis-2013-204749. Epub 2014 Feb 14.
PMID: 24532676

Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3.
Israel E, Lasky-Su J, Markezich A, Damask A, Szefler SJ, Schuemann B, Klanderman B, Sylvia J, Kazani S, Wu R, Martinez F, Boushey HA, Chinchilli VM, Mauger D, Weiss ST, Tantisira KG; SHARP Investigators.
Am J Respir Crit Care Med. 2015 Mar 1;191(5):530-7. doi: 10.1164/rccm.201408-1426OC.
PMID: 25562107, PMCID: PMC4384768

The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research.
Ritchie MD, de Andrade M, Kuivaniemi H.
Front Genet. 2015 Mar 17;6:104. doi: 10.3389/fgene.2015.00104. eCollection 2015. No abstract available.
PMID: 25852745, PMCID: PMC4362332

Genome-wide tests for introgression between cactophilic Drosophila implicate a role of inversions during speciation.
Lohse K, Clarke M, Ritchie MG, Etges WJ.
Evolution. 2015 Mar 30. doi: 10.1111/evo.12650. Epub ahead of print
PMID: 25824653

Ranking adverse drug reactions with crowdsourcing.
Gottlieb A, Hoehndorf R, Dumontier M, Altman RB.
J Med Internet Res. 2015 Mar 23;17(3):e80. doi: 10.2196/jmir.3962.
PMID: 25800813

Clinical pharmacogenetics implementation consortium (CPIC) guidelines for CYP3A5 genotype and tacrolimus dosing.
Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, Wang D, Vinks AA, He Y, Swen JJ, Leeder JS, van Schaik RH, Thummel KE, Klein TE, Caudle KE, MacPhee IA.
Clin Pharmacol Ther. 2015 Mar 18. doi: 10.1002/cpt.113. Epub ahead of print
PMID: 25801146

First-in-human pharmacokinetic and pharmacodynamic study of the dual m-TORC 1/2 inhibitor, AZD2014.
Basu B, Dean E, Puglisi M, Greystroke A, Ong M, Burke WM, Cavallin M, Bigley G, Womack C, Harrington EA, Green S, Oelmann E, de Bono JS, Ranson MR, Banerji U.
Clin Cancer Res. 2015 Mar 24. pii: clincanres.2422.2014. Epub ahead of print
PMID: 25805799

Variations in the Binding Pocket of an Inhibitor of the Bacterial Division Protein FtsZ across Genotypes and Species.
Miguel A, Hsin J, Liu T, Tang G, Altman RB, Huang KC.
PLoS Comput Biol. 2015 Mar 26;11(3):e1004117. doi: 10.1371/journal.pcbi.1004117. eCollection 2015 Mar.
PMID: 25811761

A novel Alzheimer disease locus located near the gene encoding tau protein.
Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi SH, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tárraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH Jr, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues JF, Hampel H, Kamboh MI, de Bruijn RF, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdóttir J, Kauwe JS, Wilhelmsen KC, Rujescu D, Nöthen MM, Hofman A, Jones L; IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA.
Mol Psychiatry. 2015 Mar 17. doi: 10.1038/mp.2015.23. Epub ahead of print
PMID: 25778476

Rare Genetic Variants in the CFI Gene are Associated with Advanced Age-Related Macular Degeneration and Commonly Result in Reduced Serum Factor I Levels.
Kavanagh D, Yu Y, Schramm EC, Triebwasser M, Wagner E, Raychaudhuri S, Daly MJ, Atkinson JP, Seddon JM.
Hum Mol Genet. 2015 Mar 18. pii: ddv091. Epub ahead of print
PMID: 25788521

The locus of sexual selection: moving sexual selection studies into the post-genomics era.
Wilkinson GS, Breden F, Mank JE, Ritchie MG, Higginson AD, Radwan J, Jaquiery J, Salzburger W, Arriero E, Barribeau SM, Phillips PC, Renn SC, Rowe L.
J Evol Biol. 2015 Mar 18. doi: 10.1111/jeb.12621. Epub ahead of print
PMID: 25789690

Genetic and phenotypic variation in UGT2B17, a testosterone-metabolizing enzyme, is associated with BMI in males.
Zhu AZ, Cox LS, Ahluwalia JS, Renner CC, Hatsukami DK, Benowitz NL, Tyndale RF.
Pharmacogenet Genomics. 2015 Mar 19. Epub ahead of print
PMID: 25794161

Catechol-O-methyltransferase genotype and response to Compensatory Cognitive Training in outpatients with schizophrenia.
Burton CZ, Vella L, Kelsoe JR, Bilder RM, Twamley EW.
Psychiatr Genet. 2015 Mar 5. Epub ahead of print
PMID: 25748092

Heritage-Specific Mechanisms for Cancer Adverse Reactions: One Gene Does Not Explain the World.
Knepper TC, McLeod HL.
J Clin Oncol. 2015 Mar 9. pii: JCO.2014.60.1740. Epub ahead of print No abstract available.
PMID: 25753435

Analysis for Genetic Modifiers of Disease Severity in Patients with Long QT Syndrome Type 2.
Kolder IC, Tanck MW, Postema PG, Barc J, Sinner MF, Zumhagen S, Husemann A, Stallmeyer B, Koopmann TT, Hofman N, Pfeufer A, Lichtner P, Meitinger T, Beckmann BM, Myerburg RJ, Bishopric NH, Roden DM, Kääb S, Wilde AA, Schott JJ, Schulze-Bahr E, Bezzina CR.
Circ Cardiovasc Genet. 2015 Mar 3. pii: CIRCGENETICS.114.000785. Epub ahead of print
PMID: 25737393

Pharmacogenomics in diverse practice settings: implementation beyond major metropolitan areas.
Dorfman EH, Brown Trinidad S, Morales CT, Howlett K, Burke W, Woodahl EL.
Pharmacogenomics. 2015 Mar;16(3):227-37. doi: 10.2217/pgs.14.174.
PMID: 25712186

 

February 2015Back to top

Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
Byrne EM; Psychiatric Genetics Consortium Major Depressive Disorder Working Group, Raheja UK, Stephens SH, Heath AC, Madden PA, Vaswani D, Nijjar GV, Ryan KA, Youssufi H, Gehrman PR, Shuldiner AR, Martin NG, Montgomery GW, Wray NR, Nelson EC, Mitchell BD, Postolache TT.
J Clin Psychiatry. 2015 Feb;76(2):128-34. doi: 10.4088/JCP.14m08981.
PMID: 25562672

Genetic and clinical risk prediction model for postoperative atrial fibrillation.
Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D.
Circ Arrhythm Electrophysiol. 2015 Feb;8(1):25-31. doi: 10.1161/CIRCEP.114.002300. Epub 2015 Jan 7.
PMID: 25567478, PMCID: PMC4334678

Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.
Diouf B, Crews KR, Lew G, Pei D, Cheng C, Bao J, Zheng JJ, Yang W, Fan Y, Wheeler HE, Wing C, Delaney SM, Komatsu M, Paugh SW, McCorkle JR, Lu X, Winick NJ, Carroll WL, Loh ML, Hunger SP, Devidas M, Pui CH, Dolan ME, Relling MV, Evans WE.
JAMA. 2015 Feb 24;313(8):815-23. doi: 10.1001/jama.2015.0894.
PMID: 25710658, PMCID: PMC4377066

Rare variants in neuronal excitability genes influence risk for bipolar disorder.
Ament SA, Szelinger S, Glusman G, Ashworth J, Hou L, Akula N, Shekhtman T, Badner JA, Brunkow ME, Mauldin DE, Stittrich AB, Rouleau K, Detera-Wadleigh SD, Nurnberger JI Jr, Edenberg HJ, Gershon ES, Schork N; The Bipolar Genome Study, Price ND, Gelinas R, Hood L, Craig D, McMahon FJ, Kelsoe JR, Roach JC.
Proc Natl Acad Sci U S A. 2015 Feb 17. pii: 201424958. Epub ahead of print
PMID: 25730879, PMCID: PMC4371952

Cancer based pharmacogenomics network supported with scientific evidences: from the view of drug repurposing.
Wang L, Liu H, Chute CG, Zhu Q.
BioData Min. 2015 Feb 25;8:9. doi: 10.1186/s13040-015-0042-8. eCollection 2015.
PMID: 25729430, PMCID: PMC4345035

Precision medicine to improve the risk and benefit of cancer care: genetic factors in vincristine-related neuropathy.
McLeod HL.
JAMA. 2015 Feb 24;313(8):803-4. doi: 10.1001/jama.2015.1086. No abstract available.
PMID: 25710656

Methods of integrating data to uncover genotype-phenotype interactions.
Ritchie MD, Holzinger ER, Li R, Pendergrass SA, Kim D.
Nat Rev Genet. 2015 Feb;16(2):85-97. doi: 10.1038/nrg3868. Epub 2015 Jan 13. Review.
PMID: 25582081

Pharmacogenetics of nicotine and associated smoking behaviors.
Tanner JA, Chenoweth MJ, Tyndale RF.
Curr Top Behav Neurosci. 2015;23:37-86. doi: 10.1007/978-3-319-13665-3_3.
PMID: 25655887

Closing the Gap between Knowledge and Clinical Application: Challenges for Genomic Translation.
Burke W, Korngiebel DM.
PLoS Genet. 2015 Feb 26;11(2):e1004978. doi: 10.1371/journal.pgen.1004978. eCollection 2015 Feb. Review.
PMID: 25719903

TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.
Chittani M, Zaninello R, Lanzani C, Frau F, Ortu MF, Salvi E, Fresu G, Citterio L, Braga D, Piras DA, Carpini SD, Velayutham D, Simonini M, Argiolas G, Pozzoli S, Troffa C, Glorioso V, Kontula KK, Hiltunen TP, Donner KM, Turner ST, Boerwinkle E, Chapman AB, Padmanabhan S, Dominiczak AF, Melander O, Johnson JA, Cooper-Dehoff RM, Gong Y, Rivera NV, Condorelli G, Trimarco B, Manunta P, Cusi D, Glorioso N, Barlassina C.
J Hypertens. 2015 Feb 18. Epub ahead of print
PMID: 25695618

Role of common and rare variants in SCN10A: Results from the Brugada syndrome QRS locus gene discovery collaborative study.
Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E, Prins BP, Jabbari J, Torchio M, Berthet M, Mizusawa Y, Yang T, Nannenberg EA, Dagradi F, Weeke P, Bastiaenan R, Ackerman MJ, Haunso S, Leenhardt A, Kääb S, Probst V, Redon R, Sharma S, Wilde A, Tfelt-Hansen J, Schwartz P, Roden DM, Bezzina CR, Olesen M, Darbar D, Guicheney P, Crotti L; UK10K Consortium, Jamshidi Y.
Cardiovasc Res. 2015 Feb 17. pii: cvv042. Epub ahead of print
PMID: 25691538

Common Genetic Variants and Response to Atrial Fibrillation Ablation.
Shoemaker MB, Bollmann A, Lubitz SA, Ueberham L, Saini H, Montgomery J, Edwards T, Yoneda Z, Sinner MF, Arya A, Sommer P, Delaney J, Goyal SK, Saavedra P, Kanagasundram A, Whalen SP, Roden DM, Hindricks G, Ellis CR, Ellinor PT, Darbar D, Husser D.
Circ Arrhythm Electrophysiol. 2015 Feb 14. pii: CIRCEP.114.001909. Epub ahead of print
PMID: 25684755

PharmGKB summary: very important pharmacogene information for human leukocyte antigen B.
Barbarino JM, Kroetz DL, Klein TE, Altman RB.
Pharmacogenet Genomics. 2015 Feb 2. Epub ahead of print No abstract available.
PMID: 25647431

Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM.
Clin Pharmacol Ther. 2015 Feb 9. doi: 10.1002/cpt.89. Epub ahead of print
PMID: 25676789

Genetic studies of body mass index yield new insights for obesity biology.
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, Kutalik Z, Luan J, Mägi R, Randall JC, Winkler TW, Wood AR, Workalemahu T, Faul JD, Smith JA, Hua Zhao J, Zhao W, Chen J, Fehrmann R, Hedman ÅK, Karjalainen J, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bolton JL, Bragg-Gresham JL, Buyske S, Demirkan A, Deng G, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Goel A, Gong J, Jackson AU, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Mangino M, Mateo Leach I, Medina-Gomez C, Medland SE, Nalls MA, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Shungin D, Stan¿áková A, Strawbridge RJ, Ju Sung Y, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Isaacs A, Albrecht E, Ärnlöv J, Arscott GM, Attwood AP, Bandinelli S, Barrett A, Bas IN, Bellis C, Bennett AJ, Berne C, Blagieva R, Blüher M, Böhringer S, Bonnycastle LL, Böttcher Y, Boyd HA, Bruinenberg M, Caspersen IH, Ida Chen YD, Clarke R, Warwick Daw E, de Craen AJ, Delgado G, Dimitriou M, Doney AS, Eklund N, Estrada K, Eury E, Folkersen L, Fraser RM, Garcia ME, Geller F, Giedraitis V, Gigante B, Go AS, Golay A, Goodall AH, Gordon SD, Gorski M, Grabe HJ, Grallert H, Grammer TB, Gräßler J, Grönberg H, Groves CJ, Gusto G, Haessler J, Hall P, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hengstenberg C, Holmen O, Hottenga JJ, James AL, Jeff JM, Johansson Å, Jolley J, Juliusdottir T, Kinnunen L, Koenig W, Koskenvuo M, Kratzer W, Laitinen J, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Sin Lo K, Lobbens S, Lorbeer R, Lu Y, Mach F, Magnusson PK, Mahajan A, McArdle WL, McLachlan S, Menni C, Merger S, Mihailov E, Milani L, Moayyeri A, Monda KL, Morken MA, Mulas A, Müller G, Müller-Nurasyid M, Musk AW, Nagaraja R, Nöthen MM, Nolte IM, Pilz S, Rayner NW, Renstrom F, Rettig R, Ried JS, Ripke S, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Scott WR, Seufferlein T, Shi J, Vernon Smith A, Smolonska J, Stanton AV, Steinthorsdottir V, Stirrups K, Stringham HM, Sundström J, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Tayo BO, Thorand B, Thorleifsson G, Tyrer JP, Uh HW, Vandenput L, Verhulst FC, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Warren HR, Waterworth D, Weedon MN, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q; LifeLines Cohort Study, Brennan EP, Choi M, Dastani Z, Drong AW, Eriksson P, Franco-Cereceda A, Gådin JR, Gharavi AG, Goddard ME, Handsaker RE, Huang J, Karpe F, Kathiresan S, Keildson S, Kiryluk K, Kubo M, Lee JY, Liang L, Lifton RP, Ma B, McCarroll SA, McKnight AJ, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Okada Y, Perry JR, Dorajoo R, Reinmaa E, Salem RM, Sandholm N, Scott RA, Stolk L, Takahashi A, Tanaka T, Van't Hooft FM, Vinkhuyzen AA, Westra HJ, Zheng W, Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium, Heath AC, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Blangero J, Bovet P, Campbell H, Caulfield MJ, Cesana G, Chakravarti A, Chasman DI, Chines PS, Collins FS, Crawford DC, Adrienne Cupples L, Cusi D, Danesh J, de Faire U, den Ruijter HM, Dominiczak AF, Erbel R, Erdmann J, Eriksson JG, Farrall M, Felix SB, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gejman PV, Gieger C, Gottesman O, Gudnason V, Gyllensten U, Hall AS, Harris TB, Hattersley AT, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Homuth G, Kees Hovingh G, Humphries SE, Hunt SC, Hyppönen E, Illig T, Jacobs KB, Jarvelin MR, Jöckel KH, Johansen B, Jousilahti P, Wouter Jukema J, Jula AM, Kaprio J, Kastelein JJ, Keinanen-Kiukaanniemi SM, Kiemeney LA, Knekt P, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight B, Moll FL, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Madden PA, Pasterkamp G, Peden JF, Peters A, Postma DS, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Rioux JD, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schunkert H, Schwarz PE, Sever P, Shuldiner AR, Sinisalo J, Stolk RP, Strauch K, Tönjes A, Trégouët DA, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Völker U, Waeber G, Willemsen G, Witteman JC, Zillikens MC, Adair LS, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bornstein SR, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PI, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hui J, Hunter DJ, Hveem K, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Metspalu A, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sattar N, Schadt EE, Schlessinger D, Eline Slagboom P, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Weir DR, Wichmann HE, Wilson JF, Zanen P, Borecki IB, Deloukas P, Fox CS, Heid IM, O'Connell JR, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, Franke L, Frayling TM, McCarthy MI, Visscher PM, Scherag A, Willer CJ, Boehnke M, Mohlke KL, Lindgren CM, Beckmann JS, Barroso I, North KE, Ingelsson E, Hirschhorn JN, Loos RJ, Speliotes EK.
Nature. 2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177.
PMID: 25673413

New genetic loci link adipose and insulin biology to body fat distribution.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C, Gustafsson S, Day FR, Esko T, Fall T, Kutalik Z, Luan J, Randall JC, Scherag A, Vedantam S, Wood AR, Chen J, Fehrmann R, Karjalainen J, Kahali B, Liu CT, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bragg-Gresham JL, Buyske S, Demirkan A, Ehret GB, Feitosa MF, Goel A, Jackson AU, Johnson T, Kleber ME, Kristiansson K, Mangino M, Mateo Leach I, Medina-Gomez C, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Stan¿áková A, Ju Sung Y, Tanaka T, Teumer A, Van Vliet-Ostaptchouk JV, Yengo L, Zhang W, Albrecht E, Ärnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Böhringer S, Bonnet F, Böttcher Y, Bruinenberg M, Carba DB, Caspersen IH, Clarke R, Daw EW, Deelen J, Deelman E, Delgado G, Doney AS, Eklund N, Erdos MR, Estrada K, Eury E, Friedrich N, Garcia ME, Giedraitis V, Gigante B, Go AS, Golay A, Grallert H, Grammer TB, Gräßler J, Grewal J, Groves CJ, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heikkilä K, Herzig KH, Helmer Q, Hillege HL, Holmen O, Hunt SC, Isaacs A, Ittermann T, James AL, Johansson I, Juliusdottir T, Kalafati IP, Kinnunen L, Koenig W, Kooner IK, Kratzer W, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Mach F, Magnusson PK, Mahajan A, McArdle WL, Menni C, Merger S, Mihailov E, Milani L, Mills R, Moayyeri A, Monda KL, Mooijaart SP, Mühleisen TW, Mulas A, Müller G, Müller-Nurasyid M, Nagaraja R, Nalls MA, Narisu N, Glorioso N, Nolte IM, Olden M, Rayner NW, Renstrom F, Ried JS, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Sennblad B, Seufferlein T, Sitlani CM, Vernon Smith A, Stirrups K, Stringham HM, Sundström J, Swertz MA, Swift AJ, Syvänen AC, Tayo BO, Thorand B, Thorleifsson G, Tomaschitz A, Troffa C, van Oort FV, Verweij N, Vonk JM, Waite LL, Wennauer R, Wilsgaard T, Wojczynski MK, Wong A, Zhang Q, Hua Zhao J, Brennan EP, Choi M, Eriksson P, Folkersen L, Franco-Cereceda A, Gharavi AG, Hedman ÅK, Hivert MF, Huang J, Kanoni S, Karpe F, Keildson S, Kiryluk K, Liang L, Lifton RP, Ma B, McKnight AJ, McPherson R, Metspalu A, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Olsson C, Perry JR, Reinmaa E, Salem RM, Sandholm N, Schadt EE, Scott RA, Stolk L, Vallejo EE, Westra HJ, Zondervan KT; ADIPOGen Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium; GENIE Consortium; GLGC; ICBP; International Endogene Consortium; LifeLines Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen Consortium, Amouyel P, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Blangero J, Brown MJ, Burnier M, Campbell H, Chakravarti A, Chines PS, Claudi-Boehm S, Collins FS, Crawford DC, Danesh J, de Faire U, de Geus EJ, Dörr M, Erbel R, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gieger C, Gudnason V, Haiman CA, Harris TB, Hattersley AT, Heliövaara M, Hicks AA, Hingorani AD, Hoffmann W, Hofman A, Homuth G, Humphries SE, Hyppönen E, Illig T, Jarvelin MR, Johansen B, Jousilahti P, Jula AM, Kaprio J, Kee F, Keinanen-Kiukaanniemi SM, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight B, Musk AW, Möhlenkamp S, Morris AD, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Palmer LJ, Penninx BW, Peters A, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PE, Shuldiner AR, Staessen JA, Steinthorsdottir V, Stolk RP, Strauch K, Tönjes A, Tremblay A, Tremoli E, Vohl MC, Völker U, Vollenweider P, Wilson JF, Witteman JC, Adair LS, Bochud M, Boehm BO, Bornstein SR, Bouchard C, Cauchi S, Caulfield MJ, Chambers JC, Chasman DI, Cooper RS, Dedoussis G, Ferrucci L, Froguel P, Grabe HJ, Hamsten A, Hui J, Hveem K, Jöckel KH, Kivimaki M, Kuh D, Laakso M, Liu Y, März W, Munroe PB, Njølstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sinisalo J, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Veronesi G, Walker M, Wareham NJ, Watkins H, Wichmann HE, Abecasis GR, Assimes TL, Berndt SI, Boehnke M, Borecki IB, Deloukas P, Franke L, Frayling TM, Groop LC, Hunter DJ, Kaplan RC, O'Connell JR, Qi L, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Willer CJ, Visscher PM, Yang J, Hirschhorn JN, Zillikens MC, McCarthy MI, Speliotes EK, North KE, Fox CS, Barroso I, Franks PW, Ingelsson E, Heid IM, Loos RJ, Cupples LA, Morris AP, Lindgren CM, Mohlke KL.
Nature. 2015 Feb 12;518(7538):187-96. doi: 10.1038/nature14132.
PMID: 25673412

Enabling the curation of your pharmacogenetic study.
McDonagh E, Whirl-Carrillo M, Altman R, Klein T.
Clin Pharmacol Ther. 2015 Feb;97(2):116-9. doi: 10.1002/cpt.15. Epub 2014 Dec 20.
PMID: 25670512

Lack of gene-diuretic interactions on the risk of incident gout: the Nurses' Health Study and Health Professionals Follow-up Study.
Bao Y, Curhan G, Merriman T, Plenge R, Kraft P, Choi HK.
Ann Rheum Dis. 2015 Feb 9. pii: annrheumdis-2014-206534. doi: 10.1136/annrheumdis-2014-206534. Epub ahead of print
PMID: 25667207


January 2015Back to top

Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality.
Xu H, Aldrich MC, Chen Q, Liu H, Peterson NB, Dai Q, Levy M, Shah A, Han X, Ruan X, Jiang M, Li Y, Julien JS, Warner J, Friedman C, Roden DM, Denny JC.
J Am Med Inform Assoc. 2015 Jan;22(1):179-91. doi: 10.1136/amiajnl-2014-002649. Epub 2014 Jul 22.
PMID: 25053577, PMCID: PMC4433365

Knowledge boosting: a graph-based integration approach with multi-omics data and genomic knowledge for cancer clinical outcome prediction.
Kim D, Joung JG, Sohn KA, Shin H, Park YR, Ritchie MD, Kim JH.
J Am Med Inform Assoc. 2015 Jan;22(1):109-20. doi: 10.1136/amiajnl-2013-002481. Epub 2014 Jul 7.
PMID: 25002459, PMCID: PMC4433357

Genetic simulation tools for post-genome wide association studies of complex diseases.
Chen HS, Hutter CM, Mechanic LE, Amos CI, Bafna V, Hauser ER, Hernandez RD, Li C, Liberles DA, McAllister K, Moore JH, Paltoo DN, Papanicolaou GJ, Peng B, Ritchie MD, Rosenfeld G, Witte JS, Gillanders EM, Feuer EJ.
Genet Epidemiol. 2015 Jan;39(1):11-9. doi: 10.1002/gepi.21870. Epub 2014 Nov 4.
PMID: 25371374, PMCID: PMC4270837

A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults.
Perez-Andreu V, Roberts KG, Xu H, Smith C, Zhang H, Yang W, Harvey RC, Payne-Turner D, Devidas M, Cheng IM, Carroll WL, Heerema NA, Carroll AJ, Raetz EA, Gastier-Foster JM, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Rowe JM, Luger SM, Tallman MS, Dean M, Burchard EG, Torgerson DG, Yue F, Wang Y, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Loh ML, Willman CL, Hunger SP, Mullighan CG, Yang JJ.
Blood. 2015 Jan 22;125(4):680-6. doi: 10.1182/blood-2014-09-595744. Epub 2014 Dec 2.
PMID: 25468567, PMCID: PMC4304112

Using "big data" to dissect clinical heterogeneity.
Altman RB, Ashley EA.
Circulation. 2015 Jan 20;131(3):232-3. doi: 10.1161/CIRCULATIONAHA.114.014106. No abstract available.
PMID: 25601948

CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populations.
Wassenaar CA, Ye Y, Cai Q, Aldrich MC, Knight J, Spitz MR, Wu X, Blot WJ, Tyndale RF.
Carcinogenesis. 2015 Jan;36(1):99-103. doi: 10.1093/carcin/bgu235. Epub 2014 Nov 21.
PMID: 25416559, PMCID: PMC4291053

Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using biofilter, and gene-environment interactions using the Phenx Toolkit.*
Pendergrass SA, Verma SS, Hall MA, Holzinger ER, Moore CB, Wallace JR, Dudek SM, Huggins W, Kitchner T, Waudby C, Berg R, Mccarty CA, Ritchie MD.
Pac Symp Biocomput. 2015:495-505.
PMID: 25741542

A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk.
Yarwood A, Han B, Raychaudhuri S, Bowes J, Lunt M, Pappas DA, Kremer J, Greenberg JD, Plenge R; Rheumatoid Arthritis Consortium International (RACI), Worthington J, Barton A, Eyre S.
Ann Rheum Dis. 2015 Jan;74(1):170-6. doi: 10.1136/annrheumdis-2013-204133. Epub 2013 Oct 3.
PMID: 24092415

Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for tamoxifen pharmacogenetic studies.
Johnson JA, Hamadeh IS, Langaee TY.
J Natl Cancer Inst. 2015 Jan 31;107(2). pii: dju437. doi: 10.1093/jnci/dju437. Print 2015 Feb. No abstract available.
PMID: 25638249

Identification of genetic variants or genes that are associated with Homoharringtonine (HHT) response through a genome-wide association study in human lymphoblastoid cell lines (LCLs).
Tong Y, Niu N, Jenkins G, Batzler A, Li L, Kalari KR, Wang L.
Front Genet. 2015 Jan 13;5:465. doi: 10.3389/fgene.2014.00465. eCollection 2014.
PMID: 25628645, PMCID: PMC4292778

A Novel Simple Method for Determining CYP2D6 Gene Copy Number and Identifying Allele(s) with Duplication/Multiplication.
Langaee T, Hamadeh I, Chapman AB, Gums JG, Johnson JA.
PLoS One. 2015 Jan 27;10(1):e0113808. doi: 10.1371/journal.pone.0113808. eCollection 2015.
PMID: 25625348

Inherited NUDT15 Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia.
Yang JJ, Landier W, Yang W, Liu C, Hageman L, Cheng C, Pei D, Chen Y, Crews KR, Kornegay N, Wong FL, Evans WE, Pui CH, Bhatia S, Relling MV.
J Clin Oncol. 2015 Jan 26. pii: JCO.2014.59.4671. Epub ahead of print
PMID: 25624441,

Predicting Cancer Drug Response: Advancing the DREAM.
Altman RB.
Cancer Discov. 2015 Jan 26. Epub ahead of print
PMID: 25623160

Biological interpretation of genome-wide association studies using predicted gene functions.
Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L.
Nat Commun. 2015 Jan 19;6:5890. doi: 10.1038/ncomms6890.
PMID: 25597830

Using "big data" to dissect clinical heterogeneity.
Altman RB, Ashley EA.
Circulation. 2015 Jan 20;131(3):232-3. doi: 10.1161/CIRCULATIONAHA.114.014106. No abstract available.
PMID: 25601948

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.
Lu W, Cheng YC, Chen K, Wang H, Gerhard GS, Still CD, Chu X, Yang R, Parihar A, O'Connell JR, Pollin TI, Angles-Cano E, Quon MJ, Mitchell BD, Shuldiner AR, Fu M.
Hum Mol Genet. 2015 Jan 9. pii: ddu731. Epub ahead of print
PMID: 25575512

PVAAS: Identify Variants Associated with Aberrant Splicing from RNA-seq.
Wang L, Nie JJ, A Kocher JP.
Bioinformatics. 2015 Jan 7. pii: btv001. Epub ahead of print
PMID: 25573917

A Combined Genetic and Clinical Risk Prediction Model for Postoperative Atrial Fibrillation.
Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D.
Circ Arrhythm Electrophysiol. 2015 Jan 7. pii: CIRCEP.114.002300. Epub ahead of print
PMID: 25567478

Genome-wide Association Study of Short Acting β2-agonists: A Novel Genome Wide Significant Locus on Chromosome 2 Near ASB3.
Israel E, Lasky-Su J, Markezich A, Damask A, Szefler SJ, Schuemann B, Klanderman B, Sylvia J, Kazani S, Wu R, Martinez F, Boushey HA, Chinchilli VM, Mauger D, Weiss ST, Tantisira KG; for the SHARP investigators.
Am J Respir Crit Care Med. 2015 Jan 6. Epub ahead of print
PMID: 25562107

Publications from 2014

December 2014Back to top

Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases.
McGeachie MJ, Clemmer GL, Lasky-Su J, Dahlin A, Raby BA, Weiss ST.
Genom Data. 2014 Dec 1;2:202-211.
PMID: 25838990, PMCID: PMC4378545

A call for accurate pharmacogenetic labeling: telling it like it is.
Burke W, Thummel K.
JAMA Intern Med. 2014 Dec;174(12):1945-6. doi: 10.1001/jamainternmed.2014.3276. No abstract available.
PMID: 25317574

HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: hierarchical classification systems, amino acid positions, and residues.
Reynolds RJ, Ahmed AF, Danila MI, Hughes LB; Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis Investigators, Gregersen PK, Raychaudhuri S, Plenge RM, Bridges SL Jr.
Arthritis Rheumatol. 2014 Dec;66(12):3274-82. doi: 10.1002/art.38855.
PMID: 25524867

Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Goetz MP, Sun JX, Suman VJ, Silva GO, Perou CM, Nakamura Y, Cox NJ, Stephens PJ, Miller VA, Ross JS, Chen D, Safgren SL, Kuffel MJ, Ames MM, Kalari KR, Gomez HL, Gonzalez-Angulo AM, Burgues O, Brauch HB, Ingle JN, Ratain MJ, Yelensky R.
J Natl Cancer Inst. 2014 Dec 8;107(2). pii: dju401. doi: 10.1093/jnci/dju401.
PMID: 25490892

Regulatory Polymorphisms in Human DBH Affect Peripheral Gene Expression and Sympathetic Activity.
Barrie ES, Weinshenker D, Verma A, Pendergrass S, Lange L, Ritchie MD, Wilson JG, Kuivaniemi H, Tromp G, Carey DJ, Gerhard GS, Brilliant MH, Hebbring SJ, Cubells JF, Pinsonneault JK, Norman G, Sadee W.
Circ Res. 2014 Dec 5;115(12):1017-25. doi: 10.1161/CIRCRESAHA.116.304398. Epub 2014 Oct 17.
PMID: 25326128 

Imputation and quality control steps for combining multiple genome-wide datasets.
Verma SS, de Andrade M, Tromp G, Kuivaniemi H, Pugh E, Namjou-Khales B, Mukherjee S, Jarvik GP, Kottyan LC, Burt A, Bradford Y, Armstrong GD, Derr K, Crawford DC, Haines JL, Li R, Crosslin D, Ritchie MD.
Front Genet. 2014 Dec 11;5:370. doi: 10.3389/fgene.2014.00370. eCollection 2014.
PMID: 25566314, PMCID: PMC4263197

Cladograms with Path to Event (ClaPTE): A novel algorithm to detect associations between genotypes or phenotypes using phylogenies.
Handelman SK, Aaronson JM, Seweryn M, Voronkin I, Kwiek JJ, Sadee W, Verducci JS, Janies DA.
Comput Biol Med. 2014 Dec 24;58C:1-13. doi: 10.1016/j.compbiomed.2014.12.013. Epub ahead of print
PMID: 25577610

Training the next generation of quantitative biologists in the era of big data.
Pattin KA, Greene AC, Altman RB, Cohen KB, Wethington E, Görg C, Hunter LE, Muse SV, Radivojac P, Moore JH.
Pac Symp Biocomput. 2015;20:488-92.
PMID: 25592609

A twentieth anniversary tribute to psb.
Hewett D, Whirl-Carrillo M, Hunter LE, Altman RB, Klein TE.
Pac Symp Biocomput. 2015;20:1-7.
PMID: 25592562

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes.
Sharma A, Menche J, Huang C, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA Jr, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabási AL.
Hum Mol Genet. 2015 Jan 12. pii: ddv001. Epub ahead of print
PMID: 25586491

PharmGKB summary: very important pharmacogene information for CFTR.
McDonagh EM, Clancy JP, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Dec 15. Epub ahead of print No abstract available.
PMID: 25514096

A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record.
Karnes JH, Cronin RM, Rollin J, Teumer A, Pouplard C, Shaffer CM, Blanquicett C, Bowton EA, Cowan JD, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Bakchoul T, Denny JC, Greinacher A, Gruel Y, Roden DM.
Thromb Haemost. 2014 Dec 11;113(3). Epub ahead of print
PMID: 25503805

PharmGKB summary: ibuprofen pathways.
Mazaleuskaya LL, Theken KN, Gong L, Thorn CF, FitzGerald GA, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Dec 12. Epub ahead of print No abstract available.
PMID: 25502615

Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study.
Hall MA, Verma A, Brown-Gentry KD, Goodloe R, Boston J, Wilson S, McClellan B, Sutcliffe C, Dilks HH, Gillani NB, Jin H, Mayo P, Allen M, Schnetz-Boutaud N, Crawford DC, Ritchie MD, Pendergrass SA.
PLoS Genet. 2014 Dec 4;10(12):e1004678. doi: 10.1371/journal.pgen.1004678. eCollection 2014 Dec.
PMID: 25474351

Circulating ANP Genetic Association Study Identifies a Novel Gene Cluster Associated with Stroke in Caucasians.
Pereira NL, Tosakulwong N, Scott CG, Jenkins GD, Prodduturi N, Chai Y, Olson TM, Rodeheffer RJ, Redfield MM, Weinshilboum RM, Burnett JC Jr.
Circ Cardiovasc Genet. 2014 Dec 1. pii: CIRCGENETICS.114.000624. Epub ahead of print
PMID: 25452597

Meaningful use of pharmacogenetics.
Ratain MJ, Johnson JA.
Clin Pharmacol Ther. 2014 Dec;96(6):650-2. doi: 10.1038/clpt.2014.188. No abstract available.
PMID: 25399712

Finding the epistasis needles in the genome-wide haystack.
Ritchie MD.
Methods Mol Biol. 2015;1253:19-33. doi: 10.1007/978-1-4939-2155-3_2.
PMID: 25403525

Pharmacology and Toxicology of Nav1.5-Class 1 anti-arrhythmic drugs.
Roden DM.
Card Electrophysiol Clin. 2014 Dec 1;6(4):695-704.
PMID: 25395995, PMCID: PMC4226533


November 2014Back to top

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA; Alzheimer Disease Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L.
JAMA Neurol. 2014 Nov;71(11):1394-404. doi: 10.1001/jamaneurol.2014.1491. Erratum in: JAMA Neurol. 2014 Nov;71(11):1457.
PMID: 25199842, PMCID: PMC4314944

Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer.
Pu X, Wang L, Chang JY, Hildebrandt MA, Ye Y, Lu C, Skinner HD, Niu N, Jenkins GD, Komaki R, Minna JD, Roth JA, Weinshilboum RM, Wu X.
Clin Pharmacol Ther. 2014 Nov;96(5):609-15. doi: 10.1038/clpt.2014.154. Epub 2014 Jul 23.
PMID: 25054431|http://www.ncbi.nlm.nih.gov/pubmed/25054431]

A genome-wide survey of CD4(plus) lymphocyte regulatory genetic variants identifies novel asthma genes.
Sharma S, Zhou X, Thibault DM, Himes BE, Liu A, Szefler SJ, Strunk R, Castro M, Hansel NN, Diette GB, Vonakis BM, Adkinson NF Jr, Avila L, Soto-Quiros M, Barraza-Villareal A, Lemanske RF Jr, Solway J, Krishnan J, White SR, Cheadle C, Berger AE, Fan J, Boorgula MP, Nicolae D, Gilliland F, Barnes K, London SJ, Martinez F, Ober C, Celedón JC, Carey VJ, Weiss ST, Raby BA.
J Allergy Clin Immunol. 2014 Nov;134(5):1153-62. doi: 10.1016/j.jaci.2014.04.011. Epub 2014 Jun 13.
PMID: 24934276

The pharmacodynamic properties of lurasidone and their role in its antidepressant efficacy in bipolar disorder.
Fountoulakis KN, Gazouli M, Kelsoe J, Akiskal H.
Eur Neuropsychopharmacol. 2014 Nov 29. pii: S0924-977X(14)00321-6. doi: 10.1016/j.euroneuro.2014.11.010. Epub ahead of print
PMID: 25596883

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links <i>PLCL1</i> to speech language development and <i>IL5-IL13</i> to Eosinophilic Esophagitis.
Namjou B, Marsolo K, Caroll RJ, Denny JC, Ritchie MD, Verma SS, Lingren T, Porollo A, Cobb BL, Perry C, Kottyan LC, Rothenberg ME, Thompson SD, Holm IA, Kohane IS, Harley JB.
Front Genet. 2014 Nov 18;5:401. eCollection 2014.
PMID: 25477900

Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103).
Beumer JH, Owzar K, Lewis LD, Jiang C, Holleran JL, Christner SM, Blum W, Devine S, Kolitz JE, Linker C, Vij R, Alyea EP, Larson RA, Ratain MJ, Egorin MJ.
Cancer Chemother Pharmacol. 2014 Nov;74(5):927-38. doi: 10.1007/s00280-014-2571-0. Epub 2014 Aug 28.
PMID: 25163570 

Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting.
Iwuchukwu OF, Feng Q, Wei WQ, Jiang L, Jiang M, Xu H, Denny JC, Wilke RA, Krauss RM, Roden DM, Stein CM.
Pharmacogenomics. 2014 Nov;15(14):1739-1747.
PMID: 25493567

Exploring the distribution of genetic markers of pharmacogenomics relevance in brazilian and mexican populations.
Bonifaz-Peña V, Contreras AV, Struchiner CJ, Roela RA, Furuya-Mazzotti TK, Chammas R, Rangel-Escareño C, Uribe-Figueroa L, Gómez-Vázquez MJ, McLeod HL, Hidalgo-Miranda A, Parra EJ, Fernández-López JC, Suarez-Kurtz G.
PLoS One. 2014 Nov 24;9(11):e112640. doi: 10.1371/journal.pone.0112640. eCollection 2014.
PMID: 25419701, PMCID: PMC4242606

Examining Rare and Low-Frequency Genetic Variants Previously Associated with Lone or Familial Forms of Atrial Fibrillation in an Electronic Medical Record System: A Cautionary Note.
Weeke P, Denny JC, Basterache L, Shaffer C, Bowton E, Ingram C, Darbar D, Roden DM.
Circ Cardiovasc Genet. 2014 Nov 19. pii: CIRCGENETICS.114.000718. Epub ahead of print
PMID: 25410959

Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of pazopanib.
Maitland ML, Xu CF, Cheng YC, Kistner-Griffin E, Ryan KA, Karrison TG, Das S, Torgerson D, Gamazon E, Thomeas V, Levine MR, Wilson PA, Bing NX, Liu Y, Cardon LR, Pandite L, O'Connell JR, Cox N, Mitchell B, Ratain MJ, Shuldiner A.
Clin Cancer Res. 2014 Nov 19. pii: clincanres.1683.2014. Epub ahead of print
PMID: 25411163

Large-scale gene-centric analysis identifies polymorphisms for resistant hypertension.
Fontana V, McDonough CW, Gong Y, El Rouby NM, Sá AC, Taylor KD, Chen YD, Gums JG, Chapman AB, Turner ST, Pepine CJ, Johnson JA, Cooper-DeHoff RM.
J Am Heart Assoc. 2014 Nov 10;3(6). pii: e001398. doi: 10.1161/JAHA.114.001398.
PMID: 25385345

The cost-effectiveness of returning incidental findings from next-generation genomic sequencing.
Bennette CS, Gallego CJ, Burke W, Jarvik GP, Veenstra DL.
Genet Med. 2014 Nov 13. doi: 10.1038/gim.2014.156. Epub ahead of print
PMID: 25394171

PharmGKB summary: very important pharmacogene information for CYP4F2.
Alvarellos ML, Sangkuhl K, Daneshjou R, Whirl-Carrillo M, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Nov 3. Epub ahead of print No abstract available.
PMID: 25370453

Genetic Simulation Tools for Post-Genome Wide Association Studies of Complex Diseases.
Chen HS, Hutter CM, Mechanic LE, Amos CI, Bafna V, Hauser ER, Hernandez RD, Li C, Liberles DA, McAllister K, Moore JH, Paltoo DN, Papanicolaou GJ, Peng B, Ritchie MD, Rosenfeld G, Witte JS, Gillanders EM, Feuer EJ.
Genet Epidemiol. 2014 Nov 4. doi: 10.1002/gepi.21870. Epub ahead of print
PMID: 25371374


October 2014Back to top

Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B, Salam MT, Torgerson DG, Van den Berg DJ, Vora H, Bleecker ER, Meyers DA, Williams LK, Martinez FD, Burchard EG, Barnes KC, Gilliland FD, Weiss ST, London SJ, Raby BA, Ober C, Nicolae DL; GRAAD.
Hum Mol Genet. 2014 Oct 1;23(19):5251-9. doi: 10.1093/hmg/ddu222. Epub 2014 May 13.
PMID: 24824216

Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.
Jacobsen KK, Nievergelt CM, Zayats T, Greenwood TA, Anttila V, Akiskal HS; BiGS Consortium; IHG Consortium; BiGS Consortium Co-Authors include:; IHG Consortium Co-Authors include:, Haavik J, Bernt Fasmer O, Kelsoe JR, Johansson S, Oedegaard KJ; BiGS Consortium Co-Authors include; IHG Consortium Co-Authors include.
J Affect Disord. 2014 Oct 12;172C:453-461. doi: 10.1016/j.jad.2014.10.004. Epub ahead of print
PMID: 25451450

Identification of CYP3A7 for glyburide metabolism in human fetal livers.
Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q.
Biochem Pharmacol. 2014 Oct 22;92(4):690-700. doi: 10.1016/j.bcp.2014.09.025. Epub ahead of print
PMID: 25450675

The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.
Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M.
Clin Pharmacol Ther. 2014 Oct;96(4):423-8. doi: 10.1038/clpt.2014.125. Epub 2014 Jun 11.
PMID: 24918167

Genetic variants in the complement system predisposing to age-related macular degeneration: a review.
Schramm EC, Clark SJ, Triebwasser MP, Raychaudhuri S, Seddon JM, Atkinson JP.
Mol Immunol. 2014 Oct;61(2):118-25. doi: 10.1016/j.molimm.2014.06.032. Epub 2014 Jul 15. Review.
PMID: 25034031, PMCID: PMC4149817

Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish.
Maruthur NM, Clark JM, Fu M, Linda Kao WH, Shuldiner AR.
Diabetologia. 2014 Oct 28. Epub ahead of print
PMID: 25348609

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJ, Stott DJ, Buckley BM, Ford I, Westendorp RG, Eline Slagboom P, Sattar N, Munroe PB, Sever P, Poulter N, Stanton A, Shields DC, O'Brien E, Shaw-Hawkins S, Ida Chen YD, Nickerson DA, Smith JD, Pierre Dubé M, Matthijs Boekholdt S, Kees Hovingh G, Kastelein JJ, McKeigue PM, Betteridge J, Neil A, Durrington PN, Doney A, Carr F, Morris A, McCarthy MI, Groop L, Ahlqvist E; Welcome Trust Case Control Consortium, Bis JC, Rice K, Smith NL, Lumley T, Whitsel EA, Stürmer T, Boerwinkle E, Ngwa JS, O'Donnell CJ, Vasan RS, Wei WQ, Wilke RA, Liu CT, Sun F, Guo X, Heckbert SR, Post W, Sotoodehnia N, Arnold AM, Stafford JM, Ding J, Herrington DM, Kritchevsky SB, Eiriksdottir G, Launer LJ, Harris TB, Chu AY, Giulianini F, MacFadyen JG, Barratt BJ, Nyberg F, Stricker BH, Uitterlinden AG, Hofman A, Rivadeneira F, Emilsson V, Franco OH, Ridker PM, Gudnason V, Liu Y, Denny JC, Ballantyne CM, Rotter JI, Adrienne Cupples L, Psaty BM, Palmer CN, Tardif JC, Colhoun HM, Hitman G, Krauss RM, Wouter Jukema J, Caulfield MJ; Membership of Wellcome Trust Case Control Consortium; Data and Analysis Group; DNA, Genotyping, Data QC and Informatics Group; Publications Committee; Membership of Wellcome Trust Case Control Consortium; Data and Analysis Group; DNA Genotyping Data QC and Informatics Group; Publications Committee.
Nat Commun. 2014 Oct 28;5:5068. doi: 10.1038/ncomms6068.
PMID: 25350695, PMCID: PMC4220464

The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data.
Tang X, Baheti S, Shameer K, Thompson KJ, Wills Q, Niu N, Holcomb IN, Boutet SC, Ramakrishnan R, Kachergus JM, Kocher JP, Richard W, Wang L, Thompson EA, Kalari KR.
Nucleic Acids Res. 2014 Oct 28. pii: gku1005. Epub ahead of print
PMID: 25352556

UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in European and African American smokers.
Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, Benowitz NL, Tyndale RF.
Cancer Epidemiol Biomarkers Prev. 2014 Oct 2. pii: cebp.0804.2014. Epub ahead of print
PMID: 25277794

Genome-wide discovery of drug-dependent human liver regulatory elements.
Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N.
PLoS Genet. 2014 Oct 2;10(10):e1004648. doi: 10.1371/journal.pgen.1004648. eCollection 2014 Oct.
PMID: 25275310, PMCID: PMC4183418

Further Investigation in Europeans of Susceptibility Variants for Polycystic Ovary Syndrome Discovered in Genome-wide Association Studies of Chinese Individuals.
Brower MA, Jones MR, Rotter JI, Krauss RM, Legro RS, Azziz R, Goodarzi MO.
J Clin Endocrinol Metab. 2014 Oct 10:jc20142689. Epub ahead of print
PMID: 25303487

Genetic variation in the HLA region is associated with susceptibility to herpes zoster.
Crosslin DR, Carrell DS, Burt A, Kim DS, Underwood JG, Hanna DS, Comstock BA, Baldwin E, de Andrade M, Kullo IJ, Tromp G, Kuivaniemi H, Borthwick KM, McCarty CA, Peissig PL, Doheny KF, Pugh E, Kho A, Pacheco J, Hayes MG, Ritchie MD, Verma SS, Armstrong G, Stallings S, Denny JC, Carroll RJ, Crawford DC, Crane PK, Mukherjee S, Bottinger E, Li R, Keating B, Mirel DB, Carlson CS, Harley JB, Larson EB, Jarvik GP.
Genes Immun. 2014 Oct 9;0. doi: 10.1038/gene.2014.51. Epub ahead of print
PMID: 25297839

Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five United States Medical Centers.
Dunnenberger HM, Crews KR, Hoffman JM, Caudle KE, Broeckel U, Howard SC, Hunkler RJ, Klein TE, Evans WE, Relling MV.
Annu Rev Pharmacol Toxicol. 2014 Oct 2. Epub ahead of print
PMID: 25292429

Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate.
Karpyak VM, Biernacka JM, Geske JR, Jenkins GD, Cunningham JM, Rüegg J, Kononenko O, Leontovich AA, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Skime MK, Frank J, Nöthen MM, Rietschel M, Kiefer F, Mann KF, Weinshilboum RM, Frye MA, Choi DS.
Transl Psychiatry. 2014 Oct 7;4:e453. doi: 10.1038/tp.2014.103.
PMID: 25290263

Is personalized medicine achievable in obstetrics?
Quinney SK, Patil AS, Flockhart DA.
Semin Perinatol. 2014 Oct 1. pii: S0146-0005(14)00105-0. doi: 10.1053/j.semperi.2014.08.017. Epub ahead of print Review.
PMID: 25282474

Defining the role of common variation in the genomic and biological architecture of adult human height.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC, Scherag A, Vinkhuyzen AA, Westra HJ, Winkler TW, Workalemahu T, Zhao JH, Absher D, Albrecht E, Anderson D, Baron J, Beekman M, Demirkan A, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Fraser RM, Goel A, Gong J, Justice AE, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Lui JC, Mangino M, Leach IM, Medina-Gomez C, Nalls MA, Nyholt DR, Palmer CD, Pasko D, Pechlivanis S, Prokopenko I, Ried JS, Ripke S, Shungin D, Stancáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Afzal U, Arnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Bolton JL, Böttcher Y, Boyd HA, Bruinenberg M, Buckley BM, Buyske S, Caspersen IH, Chines PS, Clarke R, Claudi-Boehm S, Cooper M, Daw EW, De Jong PA, Deelen J, Delgado G, Denny JC, Dhonukshe-Rutten R, Dimitriou M, Doney AS, Dörr M, Eklund N, Eury E, Folkersen L, Garcia ME, Geller F, Giedraitis V, Go AS, Grallert H, Grammer TB, Gräßler J, Grönberg H, de Groot LC, Groves CJ, Haessler J, Hall P, Haller T, Hallmans G, Hannemann A, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hemani G, Henders AK, Hillege HL, Hlatky MA, Hoffmann W, Hoffmann P, Holmen O, Houwing-Duistermaat JJ, Illig T, Isaacs A, James AL, Jeff J, Johansen B, Johansson A, Jolley J, Juliusdottir T, Junttila J, Kho AN, Kinnunen L, Klopp N, Kocher T, Kratzer W, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Lu Y, Lyssenko V, Magnusson PK, Mahajan A, Maillard M, McArdle WL, McKenzie CA, McLachlan S, McLaren PJ, Menni C, Merger S, Milani L, Moayyeri A, Monda KL, Morken MA, Müller G, Müller-Nurasyid M, Musk AW, Narisu N, Nauck M, Nolte IM, Nöthen MM, Oozageer L, Pilz S, Rayner NW, Renstrom F, Robertson NR, Rose LM, Roussel R, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Schunkert H, Scott RA, Sehmi J, Seufferlein T, Shi J, Silventoinen K, Smit JH, Smith AV, Smolonska J, Stanton AV, Stirrups K, Stott DJ, Stringham HM, Sundström J, Swertz MA, Syvänen AC, Tayo BO, Thorleifsson G, Tyrer JP, van Dijk S, van Schoor NM, van der Velde N, van Heemst D, van Oort FV, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Waldenberger M, Wennauer R, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boomsma DI, Bornstein SR, Bovet P, Brambilla P, Brown MJ, Campbell H, Caulfield MJ, Chakravarti A, Collins R, Collins FS, Crawford DC, Cupples LA, Danesh J, de Faire U, den Ruijter HM, Erbel R, Erdmann J, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Gansevoort RT, Gejman PV, Gieger C, Golay A, Gottesman O, Gudnason V, Gyllensten U, Haas DW, Hall AS, Harris TB, Hattersley AT, Heath AC, Hengstenberg C, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Hovingh GK, Humphries SE, Hunt SC, Hypponen E, Jacobs KB, Jarvelin MR, Jousilahti P, Jula AM, Kaprio J, Kastelein JJ, Kayser M, Kee F, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kooner JS, Kooperberg C, Koskinen S, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lupoli S, Madden PA, Männistö S, Manunta P, Marette A, Matise TC, McKnight B, Meitinger T, Moll FL, Montgomery GW, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Ouwehand WH, Pasterkamp G, Peters A, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ritchie M, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PE, Sebert S, Sever P, Shuldiner AR, Sinisalo J, Steinthorsdottir V, Stolk RP, Tardif JC, Tönjes A, Tremblay A, Tremoli E, Virtamo J, Vohl MC; The Electronic Medical Records and Genomics (eMERGE) Consortium; The MIGen Consortium; The PAGE Consortium; The LifeLines Cohort Study, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PI, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hayes MG, Hui J, Hunter DJ, Hveem K, Jukema JW, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Powell JE, Power C, Quertermous T, Rauramaa R, Reinmaa E, Ridker PM, Rivadeneira F, Rotter JI, Saaristo TE, Saleheen D, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Strauch K, Stumvoll M, Tuomilehto J, Uusitupa M, van der Harst P, Völzke H, Walker M, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Zanen P, Deloukas P, Heid IM, Lindgren CM, Mohlke KL, Speliotes EK, Thorsteinsdottir U, Barroso I, Fox CS, North KE, Strachan DP, Beckmann JS, Berndt SI, Boehnke M, Borecki IB, McCarthy MI, Metspalu A, Stefansson K, Uitterlinden AG, van Duijn CM, Franke L, Willer CJ, Price AL, Lettre G, Loos RJ, Weedon MN, Ingelsson E, O'Connell JR, Abecasis GR, Chasman DI, Goddard ME, Visscher PM, Hirschhorn JN, Frayling TM.
Nat Genet. 2014 Oct 5. doi: 10.1038/ng.3097. Epub ahead of print
PMID: 25282103

A Call for Accurate Pharmacogenetic Labeling: Telling It Like It Is.
Burke W, Thummel K.
JAMA Intern Med. 2014 Oct 13. doi: 10.1001/jamainternmed.2014.3276. Epub ahead of print No abstract available.
PMID: 25317574

 


September 2014Back to top

Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins.
Schelleman H, Han X, Brensinger CM, Quinney SK, Bilker WB, Flockhart DA, Li L, Hennessy S.
Br J Clin Pharmacol. 2014 Sep;78(3):639-48. doi: 10.1111/bcp.12353.
PMID: 24548191, PMCID: PMC4243914

PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics.
McDonagh EM, Thorn CF, Callaghan JT, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Sep;24(9):464-76. doi: 10.1097/FPC.0000000000000058. Review. No abstract available.
PMID: 24915143, PMCID: PMC4122637

Nicotine Pharmacokinetics in Rats is altered as a function of Age, impacting the Interpretation of Animal Model Data.
Craig EL, Zhao B, Cui JZ, Novalen M, Miksys S, Tyndale RF.
Drug Metab Dispos. 2014 Sep;42(9):1447-55. doi: 10.1124/dmd.114.058719. Epub 2014 Jun 30.
 PMID: 24980255, PMCID: PMC4152873

Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.
Schneider BP, Li L, Shen F, Miller KD, Radovich M, O'Neill A, Gray RJ, Lane D, Flockhart DA, Jiang G, Wang Z, Lai D, Koller D, Pratt JH, Dang CT, Northfelt D, Perez EA, Shenkier T, Cobleigh M, Smith ML, Railey E, Partridge A, Gralow J, Sparano J, Davidson NE, Foroud T, Sledge GW.
Br J Cancer. 2014 Sep 9;111(6):1241-8. doi: 10.1038/bjc.2014.430. Epub 2014 Aug 12.
PMID: 25117820

Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
Ritchie MD, Verma SS, Hall MA, Goodloe RJ, Berg RL, Carrell DS, Carlson CS, Chen L, Crosslin DR, Denny JC, Jarvik G, Li R, Linneman JG, Pathak J, Peissig P, Rasmussen LV, Ramirez AH, Wang X, Wilke RA, Wolf WA, Torstenson ES, Turner SD, McCarty CA.
Mol Vis. 2014 Sep 19;20:1281-95. eCollection 2014.
PMID: 25352737, PMCID: PMC4168835

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T, Sofat R, Stender S, Johnson PC, Scott RA, Leusink M, Verweij N, Sharp SJ, Guo Y, Giambartolomei C, Chung C, Peasey A, Amuzu A, Li K, Palmen J, Howard P, Cooper JA, Drenos F, Li YR, Lowe G, Gallacher J, Stewart MC, Tzoulaki I, Buxbaum SG, van der A DL, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Stepaniak U, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Veglia F, Ford I, Jukema JW, Westendorp RG, de Borst GJ, de Jong PA, Algra A, Spiering W, der Zee AH, Klungel OH, de Boer A, Doevendans PA, Eaton CB, Robinson JG, Duggan D; DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium, Kjekshus J, Downs JR, Gotto AM, Keech AC, Marchioli R, Tognoni G, Sever PS, Poulter NR, Waters DD, Pedersen TR, Amarenco P, Nakamura H, McMurray JJ, Lewsey JD, Chasman DI, Ridker PM, Maggioni AP, Tavazzi L, Ray KK, Seshasai SR, Manson JE, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Schreiner PJ, Fornage M, Siscovick DS, Cushman M, Kumari M, Wareham NJ, Verschuren WM, Redline S, Patel SR, Whittaker JC, Hamsten A, Delaney JA, Dale C, Gaunt TR, Wong A, Kuh D, Hardy R, Kathiresan S, Castillo BA, van der Harst P, Brunner EJ, Tybjaerg-Hansen A, Marmot MG, Krauss RM, Tsai M, Coresh J, Hoogeveen RC, Psaty BM, Lange LA, Hakonarson H, Dudbridge F, Humphries SE, Talmud PJ, Kivimäki M, Timpson NJ, Langenberg C, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Reiner AP, Keating BJ, Hingorani AD, Sattar N.
Lancet. 2014 Sep 24. pii: S0140-6736(14)61183-1. doi: 10.1016/S0140-6736(14)61183-1. Epub ahead of print
PMID: 25262344

Pharmacogenomics in Asthma Therapy: Where Are We and Where Do We Go?
Park HW, Tantisira KG, Weiss ST.
Annu Rev Pharmacol Toxicol. 2014 Sep 29. Epub ahead of print
PMID: 25292431

Warfarin pharmacogenetics.
Johnson JA, Cavallari LH.
Trends Cardiovasc Med. 2014 Sep 6. pii: S1050-1738(14)00116-9. doi: 10.1016/j.tcm.2014.09.001. Epub ahead of print Review.
PMID: 25282448

Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation.
Kim K, Bolotin E, Theusch E, Huang H, Medina MW, Krauss RM.
Genome Biol. 2014 Sep 30;15(9):460. Epub ahead of print
PMID: 25316374, PMCID: PMC4180544

Mangravite et al. reply.
Mangravite LM, Engelhardt BE, Stephens M, Krauss RM.
Nature. 2014 Sep 18;513(7518):E3. doi: 10.1038/nature13630. No abstract available.
PMID: 25230670

Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM.
Clin Pharmacol Ther. 2014 Sep;96(3):370-9. doi: 10.1038/clpt.2014.109. Epub 2014 May 22.
PMID: 24853734, PMCID: PMC4171106

Prerequisites to implementing a pharmacogenomics program in a large health-care system.
Levy KD, Decker BS, Carpenter JS, Flockhart DA, Dexter PR, Desta Z, Skaar TC.
Clin Pharmacol Ther. 2014 Sep;96(3):307-9. doi: 10.1038/clpt.2014.101. Epub 2014 May 7.
PMID: 24807457

Regulatory changes raise troubling questions for genomic testing.
Evans BJ, Dorschner MO, Burke W, Jarvik GP.
Genet Med. 2014 Sep 25. doi: 10.1038/gim.2014.127. Epub ahead of print
PMID: 25255365

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen IM, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG.
N Engl J Med. 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088.
PMID: 25207766

Genome-wide Interrogation of Longitudinal FEV1 in Children with Asthma.
Wu K, Gamazon ER, Im HK, Geeleher P, White SR, Solway J, Clemmer GL, Weiss ST, Tantisira KG, Cox NJ, Ratain MJ, Huang RS.
Am J Respir Crit Care Med. 2014 Sep 15;190(6):619-27. doi: 10.1164/rccm.201403-0460OC.
PMID: 25221879

Mangravite et al. reply.
Mangravite LM, Engelhardt BE, Stephens M, Krauss RM.
Nature. 2014 Sep 18;513(7518):E3. doi: 10.1038/nature13630. No abstract available.
PMID: 25230670

Correction: Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics.
Hariani GD, Lam ET, Havener T, Kwok PY, McLeod HL, Wagner MJ, Motsinger-Reif AA.
BMC Res Notes. 2014 Sep 17;7(1):652. Epub ahead of print
PMID: 25231544

Thymidylate Synthase Genotype-Directed Chemotherapy for Patients with Gastric and Gastroesophageal Junction Cancers.
Goff LW, Thakkar N, Du L, Chan E, Tan BR, Cardin DB, McLeod HL, Berlin JD, Zehnbauer B, Fournier C, Picus J, Wang-Gillam A, Lee W, Lockhart AC.
PLoS One. 2014 Sep 18;9(9):e107424. doi: 10.1371/journal.pone.0107424. eCollection 2014.
PMID: 25232828, PMCID: PMC4169411

Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide.
Del-Aguila JL, Cooper-DeHoff RM, Chapman AB, Gums JG, Beitelshees AL, Bailey K, Turner ST, Johnson JA, Boerwinkle E.
Pharmacogenomics J. 2014 Sep 9. doi: 10.1038/tpj.2014.46. Epub ahead of print
PMID: 25201287

Genetic determinants of age-related macular degeneration in diverse populations from the PAGE Study.
Restrepo NA, Spencer KM, Goodloe R, Garrett TA, Heiss G, B¿¿ková P, Jorgensen N, Jensen RA, Matise TC, Hindorff LA, Klein BE, Klein R, Wong TY, Cheng CY, Cornes BK, Tai ES, Ritchie MD, Haines J, Crawford DC.
Invest Ophthalmol Vis Sci. 2014 Sep 9;55(10):6839-50. doi: 10.1167/iovs.14-14246.
PMID: 25205864

Knowledge-driven genomic interactions: an application in ovarian cancer.
Kim D, Li R, Dudek SM, Frase AT, Pendergrass SA, Ritchie MD.
BioData Min. 2014 Sep 9;7:20. doi: 10.1186/1756-0381-7-20. eCollection 2014.
PMID: 25214892, PMCID: PMC4161273

Glucocorticoid Genes and the Developmental Origins of Asthma Susceptibility and Treatment Response.
Sharma S, Kho AT, Chhabra D, Qiu W, Gaedigk R, Vyhlidal CA, Leeder JS, Barraza-Villarreal A, London SJ, Gilliland F, Raby BA, Weiss ST, Tantisira KG.
Am J Respir Cell Mol Biol. 2014 Sep 5. Epub ahead of print
PMID: 25192440

Gene Variants in CYP2C19 are Associated with Altered In Vivo Bupropion Pharmacokinetics but not Bupropion Assisted Smoking Cessation Outcomes.
Zhu AZ, Zhou Q, Cox LS, Ahluwalia JS, Benowitz NL, Tyndale RF.
Drug Metab Dispos. 2014 Sep 3. pii: dmd.114.060285. Epub ahead of print
PMID: 25187485


August 2014Back to top

Pleiotropic genes for metabolic syndrome and inflammation.
Kraja AT, Chasman DI, North KE, Reiner AP, Yanek LR, Kilpeläinen TO, Smith JA, Dehghan A, Dupuis J, Johnson AD, Feitosa MF, Tekola-Ayele F, Chu AY, Nolte IM, Dastani Z, Morris A, Pendergrass SA, Sun YV, Ritchie MD, Vaez A, Lin H, Ligthart S, Marullo L, Rohde R, Shao Y, Ziegler MA, Im HK; Cross Consortia Pleiotropy (XC-Pleiotropy) Group; the Cohorts for Heart and; Aging Research in Genetic Epidemiology (CHARGE); the Genetic Investigation of Anthropometric Traits (GIANT) Consortium; the Global Lipids Genetics Consortium (GLGC); the Meta-Analyses of Glucose; Insulin-related traits Consortium (MAGIC); the Global BPgen (GBPG) Consortium; The ADIPOGen Consortium; the Women's Genome Health Study (WGHS); the Howard University Family Study (HUFS), Schnabel RB, Jørgensen T, Jørgensen ME, Hansen T, Pedersen O, Stolk RP, Snieder H, Hofman A, Uitterlinden AG, Franco OH, Ikram MA, Richards JB, Rotimi C, Wilson JG, Lange L, Ganesh SK, Nalls M, Rasmussen-Torvik LJ, Pankow JS, Coresh J, Tang W, Linda Kao WH, Boerwinkle E, Morrison AC, Ridker PM, Becker DM, Rotter JI, Kardia SL, Loos RJ, Larson MG, Hsu YH, Province MA, Tracy R, Voight BF, Vaidya D, O'Donnell CJ, Benjamin EJ, Alizadeh BZ, Prokopenko I, Meigs JB, Borecki IB.
Mol Genet Metab. 2014 Aug;112(4):317-38. doi: 10.1016/j.ymgme.2014.04.007. Epub 2014 May 9
 PMID: 24981077, PMCID: PMC4122618

Citalopram and Escitalopram Plasma Drug and Metabolite Concentrations: Genome-Wide Associations.
Ji Y, Schaid DJ, Desta Z, Kubo M, Batzler AJ, Snyder K, Mushiroda T, Kamatani N, Ogburn E, Hall-Flavin D, Flockhart D, Nakamura Y, Mrazek DA, Weinshilboum RM.
Br J Clin Pharmacol. 2014 Aug;78(2):373-83. doi: 10.1111/bcp.12348.
PMID: 24528284, PMCID: PMC4137829

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.
Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A, Linderman M, Torgerson DG, Eng CS, Pino-Yanes M, Padhukasahasram B, Yang JJ, Mathias RA, Beaty TH, Li X, Graves P, Romieu I, Navarro Bdel R, Salam MT, Vora H, Nicolae DL, Ober C, Martinez FD, Bleecker ER, Meyers DA, Gauderman WJ, Gilliland F, Burchard EG, Barnes KC, Williams LK, London SJ, Zhang B, Raby BA, Weiss ST.
BMC Med Genomics. 2014 Aug 2;7:48. doi: 10.1186/1755-8794-7-48.
PMID: 25085501

A Genome-Wide Association Study to Identify Genomic Modulators of Rate Control Therapy in Patients With Atrial Fibrillation.
Kolek MJ, Edwards TL, Muhammad R, Balouch A, Shoemaker MB, Blair MA, Kor KC, Takahashi A, Kubo M, Roden DM, Tanaka T, Darbar D.
Am J Cardiol. 2014 Aug 15;114(4):593-600. doi: 10.1016/j.amjcard.2014.05.040. Epub 2014 Jun 6.
 PMID: 25015694, PMCID: PMC4119836

Incorporating Biomarkers Into Drug Labeling.
Ratain MJ.
Clin Adv Hematol Oncol. 2014 Aug;12(8):525-528. No abstract available.
PMID: 25356576

Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer.
Innocenti F, Schilsky RL, Ramírez J, Janisch L, Undevia S, House LK, Das S, Wu K, Turcich M, Marsh R, Karrison T, Maitland ML, Salgia R, Ratain MJ.
J Clin Oncol. 2014 Aug 1;32(22):2328-34. doi: 10.1200/JCO.2014.55.2307. Epub 2014 Jun 23.
PMID: 24958824, PMCID: PMC4105486

HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.
Fernandez CA, Smith C, Yang W, Daté M, Bashford D, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Turner V, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV.
Blood. 2014 Aug 21;124(8):1266-76. doi: 10.1182/blood-2014-03-563742. Epub 2014 Jun 26.
PMID: 24970932, PMCID: PMC4141516

Interpreting the CYP2D6 results from the International Tamoxifen Pharmacogenetics Consortium.
Province MA, Altman RB, Klein TE.
Clin Pharmacol Ther. 2014 Aug;96(2):144-6. doi: 10.1038/clpt.2014.100. Review. No abstract available.
PMID: 25056393, PMCID: PMC4147833

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype.
Relling MV, McDonagh EM, Chang T, Caudle KE, McLeod HL, Haidar CE, Klein T, Luzzatto L.
Clin Pharmacol Ther. 2014 Aug;96(2):169-74. doi: 10.1038/clpt.2014.97. Epub 2014 May 2. Review.
PMID: 24787449, PMCID: PMC4111801

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index.
Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD, Bastarache L, Edwards TL, Hebbring SJ, Lin S, Hindorff LA, Crane PK, Pendergrass SA, Ritchie MD, Crawford DC, Pathak J, Bielinski SJ, Carrell DS, Crosslin DR, Ledbetter DH, Carey DJ, Tromp G, Williams MS, Larson EB, Jarvik GP, Peissig PL, Brilliant MH, McCarty CA, Chute CG, Kullo IJ, Bottinger E, Chisholm R, Smith ME, Roden DM, Denny JC.
Front Genet. 2014 Aug 5;5:250. doi: 10.3389/fgene.2014.00250. eCollection 2014.
PMID: 25177340, PMCID: PMC4134007

The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping.
Langaee TY, Zhu HJ, Wang X, El Rouby N, Markowitz JS, Goldstein JA, Johnson JA.
Pharmacogenet Genomics. 2014 Aug;24(8):381-6. doi: 10.1097/FPC.0000000000000068.
PMID: 24945780, PMCID: PMC4090277

PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.
McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. Review. No abstract available.
PMID: 24892773, PMCID: PMC4109976

Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip.
Parihar A, Wood GC, Chu X, Jin Q, Argyropoulos G, Still CD, Shuldiner AR, Mitchell BD, Gerhard GS.
Front Genet. 2014 Aug 5;5:222. doi: 10.3389/fgene.2014.00222. eCollection 2014.
PMID: 25147553, PMCID: PMC4123014

Aromatase Inhibitor-Associated Bone Fractures: A Case-Cohort GWAS and Functional Genomics.
Liu M, Goss PE, Ingle JN, Kubo M, Furukawa Y, Batzler A, Jenkins GD, Carlson EE, Nakamura Y, Schaid DJ, Chapman JA, Shepherd LE, Ellis MJ, Khosla S, Wang L, Weinshilboum RM.
Mol Endocrinol. 2014 Aug 22:me20141147. Epub ahead of print
PMID: 25148458

Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome.
Du M, Yuan T, Schilter KF, Dittmar RL, Mackinnon A, Huang X, Tschannen M, Worthey E, Jacob H, Xia S, Gao J, Tillmans L, Lu Y, Liu P, Thibodeau SN, Wang L.
Hum Mol Genet. 2014 Aug 22. pii: ddu426. Epub ahead of print
PMID: 25149474

The Effect of CYP2D6 Drug-Drug Interactions on Hydrocodone Effectiveness.
Monte AA, Heard KJ, Campbell J, Hamamura D, Weinshilboum RM, Vasiliou V.
Acad Emerg Med. 2014 Aug 24. doi: 10.1111/acem.12431. Epub 2014 Aug 24.
PMID: 25156930, PMCID: PMC4150819

Standardizing adverse drug event reporting data.
Wang L, Jiang G, Li D, Liu H.
J Biomed Semantics. 2014 Aug 12;5:36. doi: 10.1186/2041-1480-5-36. eCollection 2014.
PMID: 25157320, PMCID: PMC4142531

PharmGKB summary: gemcitabine pathway.
Alvarellos ML, Lamba J, Sangkuhl K, Thorn CF, Wang L, Klein DJ, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Aug 26. Epub ahead of print No abstract available.
PMID: 25162786

The cistrome and gene signature of androgen receptor splice variants in castration-resistant prostate cancer cells.
Lu J, Lonergan PE, Nacusi LP, Wang L, Schmidt LJ, Sun Z, Van der Steen T, Boorjian SA, Kosari F, Vasmatzis G, Klee GG, Balk SP, Huang H, Wang C, Tindall DJ.
J Urol. 2014 Aug 14. pii: S0022-5347(14)04214-1. doi: 10.1016/j.juro.2014.08.043. Epub ahead of print
PMID: 25132238

Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia.
Twamley EW, Hua JP, Burton CZ, Vella L, Chinh K, Bilder RM, Kelsoe JR.
Schizophr Res. 2014 Aug 16. pii: S0920-9964(14)00398-3. doi: 10.1016/j.schres.2014.07.041.[Epub ahead of print
PMID: 25139113

Common and rare variant analysis in early-onset bipolar disorder vulnerability.
Jamain S, Cichon S, Etain B, Mühleisen TW, Georgi A, Zidane N, Chevallier L, Deshommes J, Nicolas A, Henrion A, Degenhardt F, Mattheisen M, Priebe L, Mathieu F, Kahn JP, Henry C, Boland A, Zelenika D, Gut I, Heath S, Lathrop M, Maier W, Albus M, Rietschel M, Schulze TG, McMahon FJ, Kelsoe JR, Hamshere M, Craddock N, Nöthen MM, Bellivier F, Leboyer M.
PLoS One. 2014 Aug 11;9(8):e104326. doi: 10.1371/journal.pone.0104326. eCollection 2014.
PMID: 25111785,  PMCID: PMC4128749 

A Community-Based Multicenter Trial of Pharmacokinetically Guided 5-Fluorouracil Dosing for Personalized Colorectal Cancer Therapy.
Patel JN, O'Neil BH, Deal AM, Ibrahim JG, Sherrill GB, Olajide OA, Atluri PM, Inzerillo JJ, Chay CH, McLeod HL, Walko CM.
Oncologist. 2014 Aug 12. pii: theoncologist.2014-0132. Epub ahead of print
PMID: 25117066

Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.
Schneider BP, Li L, Shen F, Miller KD, Radovich M, O'Neill A, Gray RJ, Lane D, Flockhart DA, Jiang G, Wang Z, Lai D, Koller D, Pratt JH, Dang CT, Northfelt D, Perez EA, Shenkier T, Cobleigh M, Smith ML, Railey E, Partridge A, Gralow J, Sparano J, Davidson NE, Foroud T, Sledge GW.
Br J Cancer. 2014 Aug 12. doi: 10.1038/bjc.2014.430. Epub ahead of print
PMID: 25117820

Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A, Linderman M, Torgerson DG, Eng CS, Pino-Yanes M, Padhukasahasram B, Yang JJ, Mathias RA, Beaty TH, Li X, Graves P, Romieu I, Del Rio Navarro B, Salam MT, Vora H, Nicolae DL, Ober C, Martinez FD, Bleecker ER, Meyers DA, Gauderman WJ, Gilliland F, Burchard EG, Barnes KC, Williams LK, London SJ, Zhang B, Raby BA, Weiss ST.
BMC Med Genomics. 2014 Aug 2;7(1):48. Epub ahead of print
PMID: 25085501, PMCID: PMC4127082

Ancestry and other genetic associations with plasma PCSK9 response to simvastatin.
Theusch E, Medina MW, Rotter JI, Krauss RM.
Pharmacogenet Genomics. 2014 Aug 2. Epub ahead of print
PMID: 25089948

Metformin pharmacogenomics: current status and future directions.
Pawlyk AC, Giacomini KM, McKeon C, Shuldiner AR, Florez JC.
Diabetes. 2014 Aug;63(8):2590-9. doi: 10.2337/db13-1367.
PMID: 25060887, PMCID: PMC4113063

Metformin pharmacogenomics: biomarkers to mechanisms.
Wang L, Weinshilboum R.
Diabetes. 2014 Aug;63(8):2609-10. doi: 10.2337/db14-0609. No abstract available.
PMID: 25060891, PMCID: PMC4113071

July 2014Back to top

PharmGKB summary: tramadol pathway.
Gong L, Stamer UM, Tzvetkov MV, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Jul;24(7):374-80. doi: 10.1097/FPC.0000000000000057. No abstract available.
PMID: 24849324, PMCID: PMC4100774

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM.
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8. doi: 10.1073/pnas.1314939111. Epub 2014 Jun 24.
PMID: 24961373, PMCID: PMC4103324

Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response. An P, Straka RJ, Pollin TI, Feitosa MF, Wojczynski MK, Daw EW, O'Connell JR, Gibson Q, Ryan KA, Hopkins PN, Tsai MY, Lai CQ, Province MA, Ordovas JM, Shuldiner AR, Arnett DK, Borecki IB.
Hum Genet. 2014 Jul;133(7):919-30. doi: 10.1007/s00439-014-1435-3. Epub 2014 Mar 7.
PMID: 24604477, PMCID: PMC4112746

Response to "clinically actionable genotypes among Brazilians".
Van Driest SL, Roden DM.
Clin Pharmacol Ther. 2014 Jul;96(1):26. doi: 10.1038/clpt.2014.71. Epub 2014 Mar 28. No abstract available.
PMID: 24682028

A New System Identification Approach to Identify Genetic Variants in Sequencing Studies for a Binary Phenotype.
Kang G, Bi W, Zhao Y, Zhang JF, Yang JJ, Xu H, Loh ML, Hunger SP, Relling MV, Pounds S, Cheng C.
Hum Hered. 2014 Jul 30;78(2):104-116. Epub ahead of print
PMID: 25096228

Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records.
Sinnott JA, Dai W, Liao KP, Shaw SY, Ananthakrishnan AN, Gainer VS, Karlson EW, Churchill S, Szolovits P, Murphy S, Kohane I, Plenge R, Cai T.
Hum Genet. 2014 Jul 26.
PMID: 25062868

Genetic variant in folate homeostasis associated with lower warfarin dose in African Americans.
Daneshjou R, Gamazon ER, Burkley B, Cavallari LH, Johnson JA, Klein TE, Limdi N, Hillenmeyer S, Percha B, Karczewski KJ, Langaee T, Patel SR, Bustamante CD, Altman RB, Perera MA.
Blood. 2014 Jul 30. pii: blood-2014-04-568436. Epub ahead of print
PMID: 25079360

Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes.
Maximov PY, McDaniel RE, Fernandes DJ, Korostyshevskiy VR, Bhatta P, Muerdter TE, Flockhart DA, Jordan VC.
Br J Pharmacol. 2014 Jul 30. doi: 10.1111/bph.12864. Epub ahead of print
PMID: 25073551

Size matters: How population size influences genotype-phenotype association studies in anonymized data.
Heatherly R, Denny JC, Haines JL, Roden DM, Malin BA.
J Biomed Inform. 2014 Jul 16. pii: S1532-0464(14)00152-X. doi: 10.1016/j.jbi.2014.07.005. Epub ahead of print
PMID: 25038554

CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort.
Kitzmiller JP, Luzum JA, Baldassarre D, Krauss RM, Medina MW.
Pharmacogenet Genomics. 2014 Jul 19. Epub ahead of print
PMID: 25051018, PMCID: PMC4160394

Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality.
Xu H, Aldrich MC, Chen Q, Liu H, Peterson NB, Dai Q, Levy M, Shah A, Han X, Ruan X, Jiang M, Li Y, Julien JS, Warner J, Friedman C, Roden DM, Denny JC.
J Am Med Inform Assoc. 2014 Jul 22. pii: amiajnl-2014-002649. doi: 10.1136/amiajnl-2014-002649. Epub ahead of print
PMID: 25053577

Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer.
Pu X, Wang L, Chang JY, Hildebrandt MA, Ye Y, Lu C, Skinner HD, Niu N, Jenkins GD, Komaki R, Minna JD, Roth JA, Weinshilboum RM, Wu X.
Clin Pharmacol Ther. 2014 Jul 23. doi: 10.1038/clpt.2014.154. Epub ahead of print
PMID: 25054431

Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.
Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sànchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R.
CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.
PMID: 25029353, PMCID: PMC4120016

(Epi)Genetic Analyses of Age-Related Macular Degeneration: Case-Control and Discordant Twin Studies.
Hutchinson JN, Fagerness J, Kirby A, Reynolds R, Zak A, Gimelbrant A, Plenge R, Daly M, Chess A, Seddon JM.
Hum Hered. 2014 Jul 12;78(2):59-72. Epub ahead of print
PMID: 25033836

Comparative effectiveness of next generation genomic sequencing for disease diagnosis: Design of a randomized controlled trial in patients with colorectal cancer/polyposis syndromes.
Gallego CJ, Bennette CS, Heagerty P, Comstock B, Horike-Pyne M, Hisama F, Amendola LM, Bennett RL, Dorschner MO, Tarczy-Hornoch P, Grady WM, Fullerton SM, Trinidad SB, Regier DA, Nickerson DA, Burke W, Patrick DL, Jarvik GP, Veenstra DL.
Contemp Clin Trials. 2014 Jul 3. pii: S1551-7144(14)00098-6. doi: 10.1016/j.cct.2014.06.016.Epub ahead of print
PMID: 24997220

Knowledge boosting: a graph-based integration approach with multi-omics data and genomic knowledge for cancer clinical outcome prediction.
Kim D, Joung JG, Sohn KA, Shin H, Park YR, Ritchie MD, Kim JH.
J Am Med Inform Assoc. 2014 Jul 7. pii: amiajnl-2013-002481. doi: 10.1136/amiajnl-2013-002481.Epub ahead of print
PMID: 25002459

Establishment of CYP2D6 reference samples by multiple validated genotyping platforms.
Fang H, Liu X, Ramírez J, Choudhury N, Kubo M, Im HK, Konkashbaev A, Cox NJ, Ratain MJ, Nakamura Y, O'Donnell PH.
Pharmacogenomics J. 2014 Jul 1. doi: 10.1038/tpj.2014.27.Epub ahead of print
PMID: 24980783

June 2014Back to top

Pharmacogenetic research in partnership with American Indian and Alaska Native communities.
Woodahl EL, Lesko LJ, Hopkins S, Robinson RF, Thummel KE, Burke W.
Pharmacogenomics. 2014 Jun;15(9):1235-41. doi: 10.2217/pgs.14.91.
PMID: 25141898, PMCID: PMC4201360

Treatment Outcomes of Depression: The Pharmacogenomic Research Network Antidepressant Medication Pharmacogenomic Study.
Mrazek DA, Biernacka JM, McAlpine DE, Benitez J, Karpyak VM, Williams MD, Hall-Flavin DK, Netzel PJ, Passov V, Rohland BM, Shinozaki G, Hoberg AA, Snyder KA, Drews MS, Skime MK, Sagen JA, Schaid DJ, Weinshilboum R, Katzelnick DJ.
J Clin Psychopharmacol. 2014 Jun;34(3):313-7. doi: 10.1097/JCP.0000000000000099.
 PMID: 24743713, PMCID: PMC3992481 

Pharmacogenomics, ancestry and clinical decision making for global populations.
Ramos E, Doumatey A, Elkahloun AG, Shriner D, Huang H, Chen G, Zhou J, McLeod H, Adeyemo A, Rotimi CN.
Pharmacogenomics J. 2014 Jun;14(3):217-22. doi: 10.1038/tpj.2013.24. Epub 2013 Jul 9.
PMID: 23835662

Incorporating inter-relationships between different levels of genomic data into cancer clinical outcome prediction.
Kim D, Shin H, Sohn KA, Verma A, Ritchie MD, Kim JH.
Methods. 2014 Jun 1;67(3):344-53. doi: 10.1016/j.ymeth.2014.02.003. Epub 2014 Feb 18.
PMID: 24561168

Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics.
Hariani GD, Lam ET, Havener T, Kwok PY, McLeod HL, Wagner MJ, Motsinger-Reif AA.
BMC Res Notes. 2014 Jun 12;7:360. doi: 10.1186/1756-0500-7-360. Erratum in: BMC Res Notes. 2014;7:652. Lam, Ernest J (corrected to Lam, Ernest T).
PMID: 24924344, PMCID: PMC4068968

Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers.
Sun Z, Wang L, Eckloff BW, Deng B, Wang Y, Wampfler JA, Jang J, Wieben ED, Jen J, You M, Yang P.
BMC Med Genomics. 2014 Jun 4;7:32. doi: 10.1186/1755-8794-7-32.
PMID: 24894543, PMCID: PMC4060138

Pharmacogenetic research in partnership with American Indian and Alaska Native communities.
Woodahl EL, Lesko LJ, Hopkins S, Robinson RF, Thummel KE, Burke W.
Pharmacogenomics. 2014 Jun;15(9):1235-41. doi: 10.2217/pgs.14.91.
PMID: 25141898

Identification of pathways for bipolar disorder: a meta-analysis.
Nurnberger JI Jr, Koller DL, Jung J, Edenberg HJ, Foroud T, Guella I, Vawter MP, Kelsoe JR; Psychiatric Genomics Consortium Bipolar Group.
JAMA Psychiatry. 2014 Jun;71(6):657-64. doi: 10.1001/jamapsychiatry.2014.176.
PMID: 24718920

Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors.
Ciesielski TH, Pendergrass SA, White MJ, Kodaman N, Sobota RS, Huang M, Bartlett J, Li J, Pan Q, Gui J, Selleck SB, Amos CI, Ritchie MD, Moore JH, Williams SM.
BioData Min. 2014 Jun 30;7:10. doi: 10.1186/1756-0381-7-10. eCollection 2014.
PMID: 25071867, PMCID: PMC4112852

Return of genomic results to research participants: the floor, the ceiling, and the choices in between.
Jarvik GP, Amendola LM, Berg JS, Brothers K, Clayton EW, Chung W, Evans BJ, Evans JP, Fullerton SM, Gallego CJ, Garrison NA, Gray SW, Holm IA, Kullo IJ, Lehmann LS, McCarty C, Prows CA, Rehm HL, Sharp RR, Salama J, Sanderson S, Van Driest SL, Williams MS, Wolf SM, Wolf WA; eMERGE Act-ROR Committee and CERC Committee; CSER Act-ROR Working Group, Burke W.
Am J Hum Genet. 2014 Jun 5;94(6):818-26. doi: 10.1016/j.ajhg.2014.04.009. Epub 2014 May 8.
PMID: 24814192, PMCID: PMC4121476

Genetic risk factors for major bleeding in patients treated with warfarin in a community setting.
Roth JA, Boudreau D, Fujii MM, Farin FM, Rettie AE, Thummel KE, Veenstra DL.
Clin Pharmacol Ther. 2014 Jun;95(6):636-43. doi: 10.1038/clpt.2014.26. Epub 2014 Feb 6.
PMID: 24503627, PMCID: PMC4067047 

Integrating systems biology sources illuminates drug action.
Gottlieb A, Altman RB.
Clin Pharmacol Ther. 2014 Jun;95(6):663-9. doi: 10.1038/clpt.2014.51. Epub 2014 Feb 27.
PMID: 24577151, PMCID: PMC4029855

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype.
Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM.
Clin Pharmacol Ther. 2014 Jun;95(6):592-7. doi: 10.1038/clpt.2014.54. Epub 2014 Mar 5.
PMID: 24598717, PMCID: PMC4026598

Clinical decisions. Screening an asymptomatic person for genetic risk.
Burke W, Dimmock D.
N Engl J Med. 2014 Jun 19;370(25):2442-5. doi: 10.1056/NEJMclde1311959. No abstract available.
PMID: 24941182

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.
Wang Z, Wong T, Hashizume T, Dickmann LZ, Scian M, Koszewski NJ, Goff JP, Horst RL, Chaudhry AS, Schuetz EG, Thummel KE.
Endocrinology. 2014 Jun;155(6):2052-63. doi: 10.1210/en.2013-2013. Epub 2014 Mar 18.
PMID: 24641623, PMCID: PMC4020929

eMERGEing progress in genomics-the first seven years.
Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD.
Front Genet. 2014 Jun 17;5:184. doi: 10.3389/fgene.2014.00184. eCollection 2014. Review.
PMID: 24987407, PMCID: PMC4060012 

Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls.
Liao KP, Diogo D, Cui J, Cai T, Okada Y, Gainer VS, Murphy SN, Gupta N, Mirel D, Ananthakrishnan AN, Szolovits P, Shaw SY, Raychaudhuri S, Churchill S, Kohane I, Karlson EW, Plenge RM.
Ann Rheum Dis. 2014 Jun;73(6):1170-5. doi: 10.1136/annrheumdis-2012-203202. Epub 2013 May 28.
PMID: 23716066, PMCID: PMC3815491

Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells.
Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S.
PLoS Genet. 2014 Jun 26;10(6):e1004404. doi: 10.1371/journal.pgen.1004404. eCollection 2014 Jun.
PMID: 24968232, PMCID: PMC4072514 

Design and Anticipated Outcomes of the eMERGE-PGx Project: A Multi-Center Pilot for Pre-Emptive Pharmacogenomics in Electronic Health Record Systems.
Rasmussen-Torvik LJ, Stallings SC, Gordon AS, Almoguera B, Basford MA, Bielinski SJ, Brautbar A, Brilliant M, Carrell DS, Connolly J, Crosslin DR, Doheny KF, Gallego CJ, Gottesman O, Kim DS, Leppig KA, Li R, Lin S, Manzi S, Mejia AR, Pacheco JA, Pan V, Pathak J, Perry CL, Peterson JF, Prows CA, Ralston J, Rasmussen LV, Ritchie MD, Sadhasivam S, Scott SA, Smith M, Vega A, Vinks AA, Volpi S, Wolf WA, Bottinger E, Chisholm RL, Chute CG, Haines JL, Harley JB, Keating B, Holm IA, Kullo IJ, Jarvik GP, Larson EB, Manolio T, McCarty CA, Nickerson DA, Scherer SE, Williams MS, Roden DM, Denny JC.
Clin Pharmacol Ther. 2014 Jun 24. doi: 10.1038/clpt.2014.137. Epub ahead of print
PMID: 24960519

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC, Isaacs A, Newhouse SJ, Evans DS, Post WS, Waggott D, Lyytikäinen LP, Hicks AA, Eisele L, Ellinghaus D, Hayward C, Navarro P, Ulivi S, Tanaka T, Tester DJ, Chatel S, Gustafsson S, Kumari M, Morris RW, Naluai AT, Padmanabhan S, Kluttig A, Strohmer B, Panayiotou AG, Torres M, Knoflach M, Hubacek JA, Slowikowski K, Raychaudhuri S, Kumar RD, Harris TB, Launer LJ, Shuldiner AR, Alonso A, Bader JS, Ehret G, Huang H, Kao WH, Strait JB, Macfarlane PW, Brown M, Caulfield MJ, Samani NJ, Kronenberg F, Willeit J; CARe Consortium; COGENT Consortium, Smith JG, Greiser KH, Meyer Zu Schwabedissen H, Werdan K, Carella M, Zelante L, Heckbert SR, Psaty BM, Rotter JI, Kolcic I, Pola¿ek O, Wright AF, Griffin M, Daly MJ; DCCT/EDIC, Arnar DO, Hólm H, Thorsteinsdottir U; eMERGE Consortium, Denny JC, Roden DM, Zuvich RL, Emilsson V, Plump AS, Larson MG, O'Donnell CJ, Yin X, Bobbo M, D'Adamo AP, Iorio A, Sinagra G, Carracedo A, Cummings SR, Nalls MA, Jula A, Kontula KK, Marjamaa A, Oikarinen L, Perola M, Porthan K, Erbel R, Hoffmann P, Jöckel KH, Kälsch H, Nöthen MM; HRGEN Consortium, den Hoed M, Loos RJ, Thelle DS, Gieger C, Meitinger T, Perz S, Peters A, Prucha H, Sinner MF, Waldenberger M, de Boer RA, Franke L, van der Vleuten PA, Beckmann BM, Martens E, Bardai A, Hofman N, Wilde AA, Behr ER, Dalageorgou C, Giudicessi JR, Medeiros-Domingo A, Barc J, Kyndt F, Probst V, Ghidoni A, Insolia R, Hamilton RM, Scherer SW, Brandimarto J, Margulies K, Moravec CE, Fabiola, Fuchsberger C, O'Connell JR, Lee WK, Watt GC, Campbell H, Wild SH, El Mokhtari NE, Frey N, Asselbergs FW, Leach IM, Navis G, van den Berg MP, van Veldhuisen DJ, Kellis M, Krijthe BP, Franco OH, Hofman A, Kors JA, Uitterlinden AG, Witteman JC, Kedenko L, Lamina C, Oostra BA, Abecasis GR, Lakatta EG, Mulas A, Orrú M, Schlessinger D, Uda M, Markus MR, Völker U, Snieder H, Spector TD, Arnlöv J, Lind L, Sundström J, Syvänen AC, Kivimaki M, Kähönen M, Mononen N, Raitakari OT, Viikari JS, Adamkova V, Kiechl S, Brion M, Nicolaides AN, Paulweber B, Haerting J, Dominiczak AF, Nyberg F, Whincup PH, Hingorani AD, Schott JJ, Bezzina CR, Ingelsson E, Ferrucci L, Gasparini P, Wilson JF, Rudan I, Franke A, Mühleisen TW, Pramstaller PP, Lehtimäki TJ, Paterson AD, Parsa A, Liu Y, van Duijn CM, Siscovick DS, Gudnason V, Jamshidi Y, Salomaa V, Felix SB, Sanna S, Ritchie MD, Stricker BH, Stefansson K, Boyer LA, Cappola TP, Olsen JV, Lage K, Schwartz PJ, Kääb S, Chakravarti A, Ackerman MJ, Pfeufer A, de Bakker PI, Newton-Cheh C.
Nat Genet. 2014 Jun 22. doi: 10.1038/ng.3014. Epub ahead of print
PMID: 24952745, PMCID: PMC4124521

Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.
Albert JS, Yerges-Armstrong LM, Horenstein RB, Pollin TI, Sreenivasan UT, Chai S, Blaner WS, Snitker S, O'Connell JR, Gong DW, Breyer RJ 3rd, Ryan AS, McLenithan JC, Shuldiner AR, Sztalryd C, Damcott CM.
N Engl J Med. 2014 Jun 12;370(24):2307-15. doi: 10.1056/NEJMoa1315496. Epub 2014 May 21.
PMID: 24848981, PMCID: PMC4096982

Integrating EMR-Linked and In Vivo Functional Genetic Data to Identify New Genotype-Phenotype Associations.
Mosley JD, Van Driest SL, Weeke PE, Delaney JT, Wells QS, Bastarache L, Roden DM, Denny JC.
PLoS One. 2014 Jun 20;9(6):e100322. doi: 10.1371/journal.pone.0100322. eCollection 2014.
PMID: 24949630, PMCID: PMC4065041

Evidence synthesis and guideline development in genomic medicine: current status and future prospects.
Schully SD, Lam TK, Dotson WD, Chang CQ, Aronson N, Birkeland ML, Brewster SJ, Boccia S, Buchanan AH, Calonge N, Calzone K, Djulbegovic B, Goddard KA, Klein RD, Klein TE, Lau J, Long R, Lyman GH, Morgan RL, Palmer CG, Relling MV, Rubinstein WS, Swen JJ, Terry SF, Williams MS, Khoury MJ.
Genet Med. 2014 Jun 19. doi: 10.1038/gim.2014.69. Epub ahead of print
PMID: 24946156

The translational potential of research on the ethical, legal, and social implications of genomics.
Burke W, Appelbaum P, Dame L, Marshall P, Press N, Pyeritz R, Sharp R, Juengst E.
Genet Med. 2014 Jun 19. doi: 10.1038/gim.2014.74. Epub ahead of print
PMID: 24946153

Whole brain expression of bipolar disorder associated genes: structural and genetic analyses.
McCarthy MJ, Liang S, Spadoni AD, Kelsoe JR, Simmons AN.
PLoS One. 2014 Jun 18;9(6):e100204. doi: 10.1371/journal.pone.0100204. eCollection 2014.
PMID: 24941232, PMCID: PMC4062532

A genome-wide survey of CD4<sup>+</sup> lymphocyte regulatory genetic variants identifies novel asthma genes.
Sharma S, Zhou X, Thibault DM, Himes BE, Liu A, Szefler SJ, Strunk R, Castro M, Hansel NN, Diette GB, Vonakis BM, Adkinson NF Jr, Avila L, Soto-Quiros M, Barraza-Villareal A, Lemanske RF Jr, Solway J, Krishnan J, White SR, Cheadle C, Berger AE, Fan J, Boorgula MP, Nicolae D, Gilliland F, Barnes K, London SJ, Martinez F, Ober C, Celedón JC, Carey VJ, Weiss ST, Raby BA.
J Allergy Clin Immunol. 2014 Jun 13. pii: S0091-6749(14)00585-5. doi: 10.1016/j.jaci.2014.04.011. Epub ahead of print
PMID: 24934276

 

May 2014Back to top

PharmGKB summary: abacavir pathway.
Barbarino JM, Kroetz DL, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 May;24(5):276-82. doi: 10.1097/FPC.0000000000000040. No abstract available.
PMID: 24625462, PMCID: PMC4074515

The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function.
Billings LK, Jablonski KA, Ackerman RJ, Taylor A, Fanelli RR, McAteer JB, Guiducci C, Delahanty LM, Dabelea D, Kahn SE, Franks PW, Hanson RL, Maruthur NM, Shuldiner AR, Mayer-Davis EJ, Knowler WC, Florez JC; Diabetes Prevention Program Research Group, Rockville.
J Clin Endocrinol Metab. 2014 May;99(5):E926-30. doi: 10.1210/jc.2013-2378. Epub 2014 Jan 28.
PMID: 24471563, PMCID: PMC4010688

KRLMM: an adaptive genotype calling method for common and low frequency variants.

Liu R, Dai Z, Yeager M, Irizarry RA, Ritchie ME.
BMC Bioinformatics. 2014 May 23;15(1):158. Epub ahead of print
PMID: 24886250, PMCID: PMC4064501

Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.
Bagdas D, Muldoon PP, Zhu AZ, Tyndale RF, Damaj MI.
Neuropharmacology. 2014 May 21. pii: S0028-3908(14)00173-7. doi: 10.1016/j.neuropharm.2014.05.006. Epub ahead of print
PMID: 24859605, PMCID: PMC4106981

Vatalanib population pharmacokinetics in patients with myelodysplastic syndrome (MDS): CALGB 10105 (Alliance).
Wang X, Owzar K, Gupta P, Larson RA, Mulkey F, Miller AA, Lewis LD, Hurd D, Vij R, Ratain MJ, Murry DJ; Clinical Trials in Oncology.
Br J Clin Pharmacol. 2014 May 16. doi: 10.1111/bcp.12427. Epub ahead of print
PMID: 24838014

Using pharmacogene polymorphism panels to detect germline pharmacodynamic markers in oncology.
Hertz DL, McLeod HL.
Clin Cancer Res. 2014 May 15;20(10):2530-40. doi: 10.1158/1078-0432.CCR-13-2780.
PMID: 24831276

Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Barraza Villarreal A, Beaty TH, Carey VJ, Croteau-Chonka DC, Del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B, Salam MT, Torgerson DG, Van den Berg DJ, Vora H, Bleecker ER, Meyers DA, Williams LK, Martinez FD, Burchard EG, Barnes KC; on behalf of GRAAD, Gilliland FD, Weiss ST, London SJ, Raby BA, Ober C, Nicolae DL.
Hum Mol Genet. 2014 May 13. pii: ddu222. Epub ahead of print
PMID: 24824216

Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review.
Canestaro WJ, Austin MA, Thummel KE.
Genet Med. 2014 May 8. doi: 10.1038/gim.2014.41. Epub ahead of print
PMID: 24810685

Genotype-guided dosing of vitamin K antagonists.
Daneshjou R, Klein TE, Altman RB.
N Engl J Med. 2014 May 1;370(18):1762-3. doi: 10.1056/NEJMc1402521#SA4. No abstract available.
PMID: 24785217, PMCID: PMC4145721

Genotype-guided dosing of vitamin K antagonists.
Pereira NL, Rihal CS, Weinshilboum RM.
N Engl J Med. 2014 May 1;370(18):1762. doi: 10.1056/NEJMc1402521#SA3. No abstract available.
PMID: 24785216

April 2014Back to top

Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202.
Johnson DH, Venuto C, Ritchie MD, Morse GD, Daar ES, McLaren PJ, Haas DW.
Pharmacogenet Genomics. 2014 Apr;24(4):195-203. doi: 10.1097/FPC.0000000000000034.
PMID: 24557078, PMCID: PMC4059003 

One size fits one: pharmacogenetics in gastroenterology.
Porayette P, Flockhart D, Gupta SK.
Clin Gastroenterol Hepatol. 2014 Apr;12(4):565-70. doi: 10.1016/j.cgh.2014.01.035. Epub 2014 Jan 30. Review.
PMID: 24486737

Guidelines for investigating causality of sequence variants in human disease.
MacArthur DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J, Abecasis GR, Adams DR, Altman RB, Antonarakis SE, Ashley EA, Barrett JC, Biesecker LG, Conrad DF, Cooper GM, Cox NJ, Daly MJ, Gerstein MB, Goldstein DB, Hirschhorn JN, Leal SM, Pennacchio LA, Stamatoyannopoulos JA, Sunyaev SR, Valle D, Voight BF, Winckler W, Gunter C.
Nature. 2014 Apr 24;508(7497):469-76. doi: 10.1038/nature13127.
PMID: 24759409

Re: Concordance between CYP2D6 genotypes obtained from tumor-derived and germline DNA.
Goetz MP, Brauch H, Ratain MJ, Cox NJ, Nakamura Y, Weinshilboum R, Ingle JN.
J Natl Cancer Inst. 2014 Apr 3;106(5). pii: dju063. doi: 10.1093/jnci/dju063. No abstract available.
PMID: 24700804

Atrial fibrillation genomics: time to take the next step.
Roden DM.
J Am Coll Cardiol. 2014 Apr 1;63(12):1211-3. doi: 10.1016/j.jacc.2013.12.016. Epub 2014 Jan 30. No abstract available.
PMID: 24486270

CrossMap: a versatile tool for coordinate conversion between genome assemblies.
Zhao H, Sun Z, Wang J, Huang H, Kocher JP, Wang L.
Bioinformatics. 2014 Apr 1;30(7):1006-7. doi: 10.1093/bioinformatics/btt730. Epub 2013 Dec 18.
PMID: 24351709, PMCID: PMC3967108

Epigenetic perspectives on cancer chemotherapy response.
Liu MZ, McLeod HL, He FZ, Chen XP, Zhou HH, Shu Y, Zhang W.
Pharmacogenomics. 2014 Apr;15(5):699-715. doi: 10.2217/pgs.14.41.
PMID: 24798726

Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Rosmarin D, Palles C, Church D, Domingo E, Jones A, Johnstone E, Wang H, Love S, Julier P, Scudder C, Nicholson G, Gonzalez-Neira A, Martin M, Sargent D, Green E, McLeod H, Zanger UM, Schwab M, Braun M, Seymour M, Thompson L, Lacas B, Boige V, Ribelles N, Afzal S, Enghusen H, Jensen SA, Etienne-Grimaldi MC, Milano G, Wadelius M, Glimelius B, Garmo H, Gusella M, Lecomte T, Laurent-Puig P, Martinez-Balibrea E, Sharma R, Garcia-Foncillas J, Kleibl Z, Morel A, Pignon JP, Midgley R, Kerr D, Tomlinson I.
J Clin Oncol. 2014 Apr 1;32(10):1031-9. doi: 10.1200/JCO.2013.51.1857. Epub 2014 Mar 3. Review.
PMID: 24590654

shRNA-seq data analysis with edgeR.
Dai Z, Sheridan JM, Gearing LJ, Moore DL, Su S, Dickins RA, Blewitt ME, Ritchie ME.
F1000Res. 2014 Apr 24;3:95. doi: 10.12688/f1000research.4204. eCollection 2014.
PMID: 24860646, PMCID: PMC4023662

Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing.
Van Driest SL, Shi Y, Bowton EA, Schildcrout JS, Peterson JF, Pulley J, Denny JC, Roden DM.
Clin Pharmacol Ther. 2014 Apr;95(4):423-31. doi: 10.1038/clpt.2013.229. Epub 2013 Nov 19.
PMID: 24253661, PMCID: PMC3961508

Genetic tests: clinical validity and clinical utility.
Burke W.
Curr Protoc Hum Genet. 2014 Apr 24;81:9.15.1-8. doi: 10.1002/0471142905.hg0915s81.
PMID: 24763995, PMCID: PMC4084965

Framework for development of physician competencies in genomic medicine: report of the Competencies Working Group of the Inter-Society Coordinating Committee for Physician Education in Genomics.
Korf BR, Berry AB, Limson M, Marian AJ, Murray MF, O'Rourke PP, Passamani ER, Relling MV, Tooker J, Tsongalis GJ, Rodriguez LL.
Genet Med. 2014 Apr 24. doi: 10.1038/gim.2014.35. Epub ahead of print
PMID: 24763287

Knowledge-based Fragment Binding Prediction.
Tang GW, Altman RB.
PLoS Comput Biol. 2014 Apr 24;10(4):e1003589. doi: 10.1371/journal.pcbi.1003589. eCollection 2014 Apr.
PMID: 24762971, PMCID: PMC3998881

Family-Based Clinical Associations and Functional Characterization of the Serotonin 2A Receptor Gene (HTR2A) in Autism Spectrum Disorder.
Smith RM, Banks W, Hansen E, Sadee W, Herman GE.
Autism Res. 2014 Apr 17. doi: 10.1002/aur.1383. Epub ahead of print
PMID: 24753316, PMCID: PMC4134733

Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African American smokers.
Zhu AZ, Zhou Q, Cox LS, David SP, Ahluwalia JS, Benowitz NL, Tyndale RF.
Clin Pharmacol Ther. 2014 Apr 14. doi: 10.1038/clpt.2014.88. Epub ahead of print
PMID: 24733007, PMCID: PMC4111775

Whole-exome sequencing in familial atrial fibrillation.
Weeke P, Muhammad R, Delaney JT, Shaffer C, Mosley JD, Blair M, Short L, Stubblefield T, Roden DM, Darbar D; National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project.
Eur Heart J. 2014 Apr 11. Epub ahead of print
PMID: 24727801

Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers.
Horenstein RB, Madabushi R, Zineh I, Yerges-Armstrong LM, Peer CJ, Schuck RN, Figg WD, Shuldiner AR, Pacanowski MA.
J Clin Pharmacol. 2014 Apr 7. doi: 10.1002/jcph.293. Epub ahead of print
PMID: 24710841, PMCID: PMC4113831

Genetic heterogeneity beyond CYP2C8*3 does not explain differential sensitivity to paclitaxel-induced neuropathy.
Hertz DL, Roy S, Jack J, Motsinger-Reif AA, Drobish A, Clark LS, Carey LA, Dees EC, McLeod HL.
Breast Cancer Res Treat. 2014 May;145(1):245-54. doi: 10.1007/s10549-014-2910-1. Epub 2014 Apr 6.
PMID: 24706167

March 2014Back to top

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.
Matimba A, Li F, Livshits A, Cartwright CS, Scully S, Fridley BL, Jenkins G, Batzler A, Wang L, Weinshilboum R, Lennard L.
Pharmacogenomics. 2014 Mar;15(4):433-47. doi: 10.2217/pgs.13.226.
PMID: 24624911, PMCID: PMC4027966

Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.
Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH; (The CARDIOGENICS consortium), Tohma S, Alfredsson L, Okada Y, Xie G, Constantin A, Balsa A, Kawasaki A, Nicaise P, Amos C, Rodriguez-Rodriguez L, Chioccia G, Boileau C, Zhang J, Vittecoq O, Barnetche T, Gonzalez Gay MA, Furukawa H, Cantagrel A, Le Loët X, Sumida T, Hurtado-Nedelec M, Richez C, Chollet-Martin S, Schaeverbeke T, Combe B, Khoryati L, Coustet B, El-Benna J, Siminovitch K, Plenge R, Padyukov L, Martin J, Tsuchiya N, Dieudé P.
Ann Rheum Dis. 2015 Mar;74(3):e19. doi: 10.1136/annrheumdis-2013-204581. Epub 2014 Jan 21.
PMID: 24448344 

 The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons.
Parker DJ, Gardiner A, Neville MC, Ritchie MG, Goodwin SF.
Heredity (Edinb). 2014 Mar;112(3):300-6. doi: 10.1038/hdy.2013.106. Epub 2013 Oct 23.
PMID: 24149653, PMCID: PMC3931162

Statin-induced changes in gene expression in EBV-transformed and native B-cells.
Bolotin E, Armendariz A, Kim K, Heo SJ, Boffelli D, Tantisira K, Rotter JI, Krauss RM, Medina MW.
Hum Mol Genet. 2014 Mar 1;23(5):1202-10. doi: 10.1093/hmg/ddt512. Epub 2013 Oct 30.
PMID: 24179175, PMCID: PMC3919007

Genetic influence on exercise-induced changes in physical function among mobility-limited older adults.
Buford TW, Hsu FC, Brinkley TE, Carter CS, Church TS, Dodson JA, Goodpaster BH, McDermott MM, Nicklas BJ, Yank V, Johnson JA, Pahor M; LIFE Research Group.
Physiol Genomics. 2014 Mar 1;46(5):149-58. doi: 10.1152/physiolgenomics.00169.2013. Epub 2014 Jan 14.
PMID: 24423970, PMCID: PMC3949106

Warfarin pharmacogenetics: an illustration of the importance of studies in minority populations.
Perera MA, Cavallari LH, Johnson JA.
Clin Pharmacol Ther. 2014 Mar;95(3):242-4. doi: 10.1038/clpt.2013.209. No abstract available.
PMID: 24548987, PMCID: PMC4131541

Progress in pharmacogenomics: bridging the gap from research to practice.
Cascorbi I, Tyndale R.
Clin Pharmacol Ther. 2014 Mar;95(3):231-5. doi: 10.1038/clpt.2013.235.
PMID: 24548984

PharmGKB summary: very important pharmacogene information for SLC22A1.
Goswami S, Gong L, Giacomini K, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Mar 27. Epub ahead of print No abstract available.
PMID: 24681965, PMCID: PMC4035531

Clinical interpretation and implications of whole-genome sequencing.
Dewey FE, Grove ME, Pan C, Goldstein BA, Bernstein JA, Chaib H, Merker JD, Goldfeder RL, Enns GM, David SP, Pakdaman N, Ormond KE, Caleshu C, Kingham K, Klein TE, Whirl-Carrillo M, Sakamoto K, Wheeler MT, Butte AJ, Ford JM, Boxer L, Ioannidis JP, Yeung AC, Altman RB, Assimes TL, Snyder M, Ashley EA, Quertermous T.
JAMA. 2014 Mar 12;311(10):1035-45. doi: 10.1001/jama.2014.1717.
PMID: 24618965, PMCID: PMC4119063

The genomic origins of asthma.
Sharma S, Chhabra D, Kho AT, Hayden LP, Tantisira KG, Weiss ST.
Thorax. 2014 Mar 25. doi: 10.1136/thoraxjnl-2014-205166. Epub ahead of print
PMID: 24668408

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.
Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, Dechene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D Jr, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzy Ski P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, Macarthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, Deluca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovre I L, Palanda I A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin D, Ament SA, Rowen L, Richards DR, Lucas FA, Gonzalez-Garay ML, Caskey CT, Bai Y, Huang Y, Fang F, Zhang Y, Wang Z, Barrera J, Garcia-Lobo JM, González-Lamuño D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M, Hart RK, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M, Li P, Kong Y, Alexander AC, Albertyn ZI, Boycott KM, Bulman DE, Gordon PM, Innes AM, Knoppers BM, Majewski J, Marshall CR, Parboosingh JS, Sawyer SL, Samuels ME, Schwartzentruber J, Kohane IS, Margulies DM.
Genome Biol. 2014 Mar 25;15(3):R53. Epub ahead of print
PMID: 24667040, PMCID: PMC4073084

Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome.
Leventhal AM, Lee W, Bergen AW, Swan GE, Tyndale RF, Lerman C, Conti DV.
Drug Alcohol Depend. 2014 Mar 5. pii: S0376-8716(14)00071-4. doi: 10.1016/j.drugalcdep.2014.02.016. Epub ahead of print
PMID: 24667010, PMCID: PMC4095777

Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke.
Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Weinstein G, Hsu FC, Beiser A, Wang L, Bookman E, Doheny KF, Wolf PA, Zilka M, Selhub J, Nelson S, Gogarten SM, Worrall BB, Seshadri S, Sale MM; Genomics and Randomized Trials Network; Framingham Heart Study.
PLoS Genet. 2014 Mar 20;10(3):e1004214. doi: 10.1371/journal.pgen.1004214. eCollection 2014 Mar.
PMID: 24651765, PMCID: PMC3961178

Characterizing genetic variants for clinical action.
Ramos EM, Din-Lovinescu C, Berg JS, Brooks LD, Duncanson A, Dunn M, Good P, Hubbard TJ, Jarvik GP, O'Donnell C, Sherry ST, Aronson N, Biesecker LG, Blumberg B, Calonge N, Colhoun HM, Epstein RS, Flicek P, Gordon ES, Green ED, Green RC, Hurles M, Kawamoto K, Knaus W, Ledbetter DH, Levy HP, Lyon E, Maglott D, McLeod HL, Rahman N, Randhawa G, Wicklund C, Manolio TA, Chisholm RL, Williams MS.
Am J Med Genet C Semin Med Genet. 2014 Mar;166(1):93-104. doi: 10.1002/ajmg.c.31386. Epub 2014 Mar 13.
PMID: 24634402, PMCID: PMC4158437 

Implementation of a pharmacogenomics service in a community pharmacy.
Ferreri SP, Greco AJ, Michaels NM, O'Connor SK, Chater RW, Viera AJ, Faruki H, McLeod HL, Roederer MW.
J Am Pharm Assoc (2003). 2014 Mar 1;54(2):172-80. doi: 10.1331/JAPhA.2014.13033.
PMID: 24632932

High precision prediction of functional sites in protein structures.
Buturovic L, Wong M, Tang GW, Altman RB, Petkovic D.
PLoS One. 2014 Mar 14;9(3):e91240. doi: 10.1371/journal.pone.0091240. eCollection 2014.
PMID: 24632601, PMCID: PMC3954699

Common genetic variants modulate pathogen-sensing responses in human dendritic cells.
Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A, Hacohen N.
Science. 2014 Mar 7;343(6175):1246980. doi: 10.1126/science.1246980.
PMID: 24604203, PMCID: PMC4124741

PG4KDS: a model for the clinical implementation of pre-emptive pharmacogenetics.
Hoffman JM, Haidar CE, Wilkinson MR, Crews KR, Baker DK, Kornegay NM, Yang W, Pui CH, Reiss UM, Gaur AH, Howard SC, Evans WE, Broeckel U, Relling MV.
Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):45-55. doi: 10.1002/ajmg.c.31391. Epub 2014 Mar 11.
PMID: 24619595, PMCID: PMC4056586

Implementation of pharmacogenetics: The University of Maryland personalized anti-platelet pharmacogenetics program.
Shuldiner AR, Palmer K, Pakyz RE, Alestock TD, Maloney KA, O'Neill C, Bhatty S, Schub J, Overby CL, Horenstein RB, Pollin TI, Kelemen MD, Beitelshees AL, Robinson SW, Blitzer MG, McArdle PF, Brown L, Jeng LJ, Zhao RY, Ambulos N, Vesely MR.
Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):76-84. doi: 10.1002/ajmg.c.31396. Epub 2014 Mar 10.
PMID: 24616408, PMCID: PMC4066997

Adoption of a clinical pharmacogenomics implementation program during outpatient care-initial results of the University of Chicago "1,200 Patients Project"
O'Donnell PH, Danahey K, Jacobs M, Wadhwa NR, Yuen S, Bush A, Sacro Y, Sorrentino MJ, Siegler M, Harper W, Warrick A, Das S, Saner D, Corless CL, Ratain MJ.
Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):68-75. doi: 10.1002/ajmg.c.31385. Epub 2014 Mar 10.
PMID: 24616296, PMCID: PMC4000170

PharmGKB summary: very important pharmacogene information for UGT1A1.
Barbarino JM, Haidar CE, Klein TE, Altman RB.
Pharmacogenet Genomics. 2014 Mar;24(3):177-83. doi: 10.1097/FPC.0000000000000024. No abstract available.
PMID: 24492252, PMCID: PMC4091838

February 2014Back to top

A genome-wide association study of bronchodilator response in asthmatics.
Duan QL, Lasky-Su J, Himes BE, Qiu W, Litonjua AA, Damask A, Lazarus R, Klanderman B, Irvin CG, Peters SP, Hanrahan JP, Lima JJ, Martinez FD, Mauger D, Chinchilli VM, Soto-Quiros M, Avila L, Celedón JC, Lange C, Weiss ST, Tantisira KG.
Pharmacogenomics J. 2014 Feb;14(1):41-7. doi: 10.1038/tpj.2013.5. Epub 2013 Mar 19.
PMID: 23508266, PMCID: PMC3706515

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Del-Aguila JL, Beitelshees AL, Cooper-Dehoff RM, Chapman AB, Gums JG, Bailey K, Gong Y, Turner ST, Johnson JA, Boerwinkle E.
Pharmacogenomics J. 2014 Feb;14(1):35-40. doi: 10.1038/tpj.2013.3. Epub 2013 Feb 12.
PMID: 23400010, PMCID: PMC3812324

Clinically relevant cancer biomarkers and pharmacogenetic assays.
Patel JN, Mandock K, McLeod HL.
J Oncol Pharm Pract. 2014 Feb;20(1):65-72. doi: 10.1177/1078155212473862. Epub 2013 Jan 24. Review.
PMID: 23353710

Essential elements of personalized medicine.
Burke W, Brown Trinidad S, Press NA.
Urol Oncol. 2014 Feb;32(2):193-7. doi: 10.1016/j.urolonc.2013.09.002. Epub 2013 Dec 8.
PMID: 24321254, PMCID: PMC3909672

PharmGKB summary: ifosfamide pathways, pharmacokinetics and pharmacodynamics.
Lowenberg D, Thorn CF, Desta Z, Flockhart DA, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Feb;24(2):133-8. doi: 10.1097/FPC.0000000000000019. No abstract available.
PMID: 24401834, PMCID: PMC4084804

Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo.
Piliguian M, Zhu AZ, Zhou Q, Benowitz NL, Ahluwalia JS, Sanderson Cox L, Tyndale RF.
Pharmacogenet Genomics. 2014 Feb;24(2):118-28. doi: 10.1097/FPC.0000000000000026.
PMID: 24305170, PMCID: PMC3931261

A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.
Ramírez J, Kim TW, Liu W, Myers JL, Mirkov S, Owzar K, Watson D, Mulkey F, Gamazon ER, Stock W, Undevia S, Innocenti F, Ratain MJ.
Pharmacogenet Genomics. 2014 Feb;24(2):129-32. doi: 10.1097/FPC.0000000000000023.
PMID: 24300566, PMCID: PMC3901533

A genome-wide association study of bronchodilator response in Latinos implicates rare variants.
Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG.
J Allergy Clin Immunol. 2014 Feb;133(2):370-8. doi: 10.1016/j.jaci.2013.06.043. Epub 2013 Aug 29.
PMID: 23992748, PMCID: PMC3938989

Personal DNA donation to energize genomic medicine.
Lu WJ, Flockhart DA.
Clin Pharmacol Ther. 2014 Feb;95(2):129-31. doi: 10.1038/clpt.2013.131.
PMID: 24448457

Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology.
Kaddurah-Daouk R, Weinshilboum RM; Pharmacometabolomics Research Network.
Clin Pharmacol Ther. 2014 Feb;95(2):154-67. doi: 10.1038/clpt.2013.217. Epub 2013 Nov 5. Review.
PMID: 24193171

CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.
Province MA, Goetz MP, Brauch H, Flockhart DA, Hebert JM, Whaley R, Suman VJ, Schroth W, Winter S, Zembutsu H, Mushiroda T, Newman WG, Lee MT, Ambrosone CB, Beckmann MW, Choi JY, Dieudonné AS, Fasching PA, Ferraldeschi R, Gong L, Haschke-Becher E, Howell A, Jordan LB, Hamann U, Kiyotani K, Krippl P, Lambrechts D, Latif A, Langsenlehner U, Lorizio W, Neven P, Nguyen AT, Park BW, Purdie CA, Quinlan P, Renner W, Schmidt M, Schwab M, Shin JG, Stingl JC, Wegman P, Wingren S, Wu AH, Ziv E, Zirpoli G, Thompson AM, Jordan VC, Nakamura Y, Altman RB, Ames MM, Weinshilboum RM, Eichelbaum M, Ingle JN, Klein TE; International Tamoxifen Pharmacogenomics Consortium.
Clin Pharmacol Ther. 2014 Feb;95(2):216-27. doi: 10.1038/clpt.2013.186. Epub 2013 Sep 23.
PMID: 24060820, PMCID: PMC3904554

Hydrochlorothiazide-induced hyperuricaemia in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study.
Vandell AG, McDonough CW, Gong Y, Langaee TY, Lucas AM, Chapman AB, Gums JG, Beitelshees AL, Bailey KR, Johnson RJ, Boerwinkle E, Turner ST, Cooper-Dehoff RM, Johnson JA.
J Intern Med. 2014 Nov;276(5):486-97. doi: 10.1111/joim.12215. Epub 2014 Feb 28.
PMID: 24612202, PMCID: PMC4130802

Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; RACI consortium; GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM.
Nature. 2014 Feb 20;506(7488):376-81. doi: 10.1038/nature12873. Epub 2013 Dec 25.
PMID: 24390342, PMCID: PMC3944098

Development and use of active clinical decision support for preemptive pharmacogenomics.
Bell GC, Crews KR, Wilkinson MR, Haidar CE, Hicks JK, Baker DK, Kornegay NM, Yang W, Cross SJ, Howard SC, Freimuth RR, Evans WE, Broeckel U, Relling MV, Hoffman JM.
J Am Med Inform Assoc. 2014 Feb;21(e1):e93-9. doi: 10.1136/amiajnl-2013-001993. Epub 2013 Aug 26.
PMID: 23978487, PMCID: PMC3957400

Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.
Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JM, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME, Leach IM, McDonough CW, Meijs MF, Melander O, Nelson CP, Nolte IM, Pankratz N, Price TS, Shaffer J, Shah S, Tomaszewski M, van der Most PJ, Van Iperen EP, Vonk JM, Witkowska K, Wong CO, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Brown M, Burt A, Cooper-Dehoff RM, Connell JM, Cruickshanks KJ, Curtis SP, Davey-Smith G, Delles C, Gansevoort RT, Guo X, Haiqing S, Hastie CE, Hofker MH, Hovingh GK, Kim DS, Kirkland SA, Klein BE, Klein R, Li YR, Maiwald S, Newton-Cheh C, O'Brien ET, Onland-Moret NC, Palmas W, Parsa A, Penninx BW, Pettinger M, Vasan RS, Ranchalis JE, M Ridker P, Rose LM, Sever P, Shimbo D, Steele L, Stolk RP, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Wyatt S, Young JH, Zwinderman AH, Bezzina CR, Boerwinkle E, Casas JP, Caulfield MJ, Chakravarti A, Chasman DI, Davidson KW, Doevendans PA, Dominiczak AF, Fitzgerald GA, Gums JG, Fornage M, Hakonarson H, Halder I, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W, Kumari M, März W, Murray SS, O'Connell JR, Oldehinkel AJ, Pankow JS, Rader DJ, Redline S, Reilly MP, Schadt EE, Kottke-Marchant K, Snieder H, Snyder M, Stanton AV, Tobin MD, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Watkins H, Johnson AD, Reiner AP, Zhu X, de Bakker PI, Levy D, Asselbergs FW, Munroe PB, Keating BJ.
Am J Hum Genet. 2014 Feb 19. pii: S0002-9297(13)00613-7. doi: 10.1016/j.ajhg.2013.12.016. Epub ahead of print
PMID: 24560520, PMCID: PMC3880605

Exome Sequencing Implicates an Increased Burden of Rare Potassium Channel Variants in the Risk of Drug Induced Long QT Syndrome.
Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL Jr, Roden DM.
J Am Coll Cardiol. 2014 Feb 7. pii: S0735-1097(14)00446-X. doi: 10.1016/j.jacc.2014.01.031. Epub ahead of print
PMID: 24561134, PMCID: PMC4018823

Pharmacoepidemiologic and in Vitro Evaluation of Potential Drug-Drug Interactions of Sulfonylureas with Fibrates and Statins.
Schelleman H, Han X, Brensinger CM, Quinney SK, Bilker WB, Flockhart DA, Li L, Hennessy S.
Br J Clin Pharmacol. 2014 Feb 18. doi: 10.1111/bcp.12353. Epub ahead of print
PMID: 24548191

Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
Chhibber A, Mefford J, Stahl EA, Pendergrass SA, Baldwin RM, Owzar K, Li M, Winer EP, Hudis CA, Zembutsu H, Kubo M, Nakamura Y, McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, Kroetz DL.
Pharmacogenomics J. 2014 Feb 11. doi: 10.1038/tpj.2014.2. Epub ahead of print
PMID: 24513692, PMCID: PMC4111770

Coherent functional modules improve transcription factor target identification, cooperativity prediction, and disease association.
Karczewski KJ, Snyder M, Altman RB, Tatonetti NP.
PLoS Genet. 2014 Feb 6;10(2):e1004122. doi: 10.1371/journal.pgen.1004122. eCollection 2014 Feb.
PMID: 24516403, PMCID: PMC3916285

Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene.
Okada Y, Diogo D, Greenberg JD, Mouassess F, Achkar WA, Fulton RS, Denny JC, Gupta N, Mirel D, Gabriel S, Li G, Kremer JM, Pappas DA, Carroll RJ, Eyler AE, Trynka G, Stahl EA, Cui J, Saxena R, Coenen MJ, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Barton A, Canhão H, Fonseca JE, de Vries N, Tak PP, Moreland LW, Bridges SL Jr, Miceli-Richard C, Choi HK, Kamatani Y, Galan P, Lathrop M, Raj T, De Jager PL, Raychaudhuri S, Worthington J, Padyukov L, Klareskog L, Siminovitch KA, Gregersen PK, Mardis ER, Arayssi T, Kazkaz LA, Plenge RM.
PLoS One. 2014 Feb 10;9(2):e87645. doi: 10.1371/journal.pone.0087645. eCollection 2014.
PMID: 24520335, PMCID: PMC3919745

CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy.
Ding L, Chen S, Liu P, Pan Y, Zhong J, Regan KM, Wang L, Yu C, Rizzardi T, Cheng L, Zhang J, Schmechel SC, Cheville JC, van Deursen J, Tindall DJ, Huang H.
Cancer Res. 2014 Feb 3. Epub ahead of print
PMID: 24491799, PMCID: PMC3975662

Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.
Brown CC, Havener TM, Medina MW, Jack JR, Krauss RM, McLeod HL, Motsinger-Reif AA.
Pharmacogenomics. 2014 Feb;15(2):137-46. doi: 10.2217/pgs.13.213.
PMID: 24444404, PMCID: PMC4055088

 

January 2014Back to top

Validation of PhenX measures in the personalized medicine research project for use in gene/environment studies.
McCarty CA, Berg R, Rottscheit CM, Waudby CJ, Kitchner T, Brilliant M, Ritchie MD.
BMC Med Genomics. 2014 Jan 14;7:3. doi: 10.1186/1755-8794-7-3.
PMID: 24423110, PMCID: PMC3896802

Pharmacokinetic and pharmacodynamics studies of nicotine after oral administration in mice: effects of methoxsalen, a CYP2A5/6 inhibitor.
Alsharari SD, Siu EC, Tyndale RF, Damaj MI.
Nicotine Tob Res. 2014 Jan;16(1):18-25. doi: 10.1093/ntr/ntt105. Epub 2013 Jul 24.
PMID: 23884323, PMCID: PMC3864487

PATH-SCAN: a reporting tool for identifying clinically actionable variants.
Daneshjou R, Zappala Z, Kukurba K, Boyle SM, Ormond KE, Klein TE, Snyder M, Bustamante CD, Altman RB, Montgomery SB.
Pac Symp Biocomput. 2014:229-40.
PMID: 24297550, PMCID: PMC4008882

Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients.
Oetjens M, Bush WS, Birdwell KA, Dilks HH, Bowton EA, Denny JC, Wilke RA, Roden DM, Crawford DC.
Pac Symp Biocomput. 2014:253-64.
PMID: 24297552, PMCID: PMC3923429

Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges.
Diogo D, Okada Y, Plenge RM.
Curr Opin Rheumatol. 2014 Jan;26(1):85-92. doi: 10.1097/BOR.0000000000000012. Review.
PMID: 24276088

Fast pairwise IBD association testing in genome-wide association studies.
Han B, Kang EY, Raychaudhuri S, de Bakker PI, Eskin E.
Bioinformatics. 2014 Jan 15;30(2):206-13. doi: 10.1093/bioinformatics/btt609. Epub 2013 Oct 24.
PMID: 24158599, PMCID: PMC3892684

PharmGKB summary: mycophenolic acid pathway.
Lamba V, Sangkuhl K, Sanghavi K, Fish A, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Jan;24(1):73-9. doi: 10.1097/FPC.0000000000000010. Review. No abstract available.
PMID: 24220207, PMCID: PMC4091813

PharmGKB summary: venlafaxine pathway.
Sangkuhl K, Stingl JC, Turpeinen M, Altman RB, Klein TE.
Pharmacogenet Genomics. 2014 Jan;24(1):62-72. doi: 10.1097/FPC.0000000000000003. Review. No abstract available.
PMID: 24128936, PMCID: PMC4098656

Patients' understanding of how genotype variation affects benefits of tamoxifen therapy for breast cancer.
Brewer NT, Defrank JT, Chiu WK, Ibrahim JG, Walko CM, Rubin P, Olajide OA, Moore SG, Raab RE, Carrizosa DR, Corso SW, Schwartz G, Peppercorn JM, McLeod HL, Carey LA, Irvin WJ Jr.
Public Health Genomics. 2014;17(1):43-7. doi: 10.1159/000356565. Epub 2014 Jan 22.
PMID: 24457521, PMCID: PMC4058990

Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein.
Suhy A, Hartmann K, Newman L, Papp A, Toneff T, Hook V, Sadee W.
Biochem Biophys Res Commun. 2014 Jan 24;443(4):1270-4. doi: 10.1016/j.bbrc.2013.12.127. Epub 2014 Jan 3.
PMID: 24393849, PMCID: PMC3929938

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P, Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm RL, Larson EB, McCarty CA, Roden DM, Jarvik GP, Kullo IJ.
Hum Genet. 2014 Jan;133(1):95-109. doi: 10.1007/s00439-013-1355-7. Epub 2013 Sep 12.
PMID: 24026423, PMCID: PMC3880605

Preemptive genotyping for personalized medicine: design of the right drug, right dose, right time-using genomic data to individualize treatment protocol.
Bielinski SJ, Olson JE, Pathak J, Weinshilboum RM, Wang L, Lyke KJ, Ryu E, Targonski PV, Van Norstrand MD, Hathcock MA, Takahashi PY, McCormick JB, Johnson KJ, Maschke KJ, Rohrer Vitek CR, Ellingson MS, Wieben ED, Farrugia G, Morrisette JA, Kruckeberg KJ, Bruflat JK, Peterson LM, Blommel JH, Skierka JM, Ferber MJ, Black JL, Baudhuin LM, Klee EW, Ross JL, Veldhuizen TL, Schultz CG, Caraballo PJ, Freimuth RR, Chute CG, Kullo IJ.
Mayo Clin Proc. 2014 Jan;89(1):25-33. doi: 10.1016/j.mayocp.2013.10.021.
PMID: 24388019, PMCID: PMC3932754

Genetic variation in the β1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery.
Jeff JM, Donahue BS, Brown-Gentry K, Roden DM, Crawford DC, Stein CM, Kurnik D.
Am Heart J. 2014 Jan;167(1):101-108.e1. doi: 10.1016/j.ahj.2013.09.016. Epub 2013 Oct 17.
PMID: 24332148, PMCID: PMC3868008

Cloud-based simulations on Google Exacycle reveal ligand modulation of GPCR activation pathways.
Kohlhoff KJ, Shukla D, Lawrenz M, Bowman GR, Konerding DE, Belov D, Altman RB, Pande VS.
Nat Chem. 2014 Jan;6(1):15-21. doi: 10.1038/nchem.1821. Epub 2013 Dec 15.
PMID: 24345941, PMCID: PMC3923464

The INFLUENCE of rare Genetic variation in SLC30A8 on diabetes incidence and beta-cell function.
Billings LK, Jablonski KA, Ackerman RJ, Taylor A, Fanelli RR, McAteer JB, Guiducci C, Delahanty LM, Dabelea D, Kahn SE, Franks PW, Hanson RL, Maruthur NM, Shuldiner A, Mayer-Davis EJ, Knowler WC, Florez JC; for the Diabetes Prevention Program Research Group, Rockville, MD.
J Clin Endocrinol Metab. 2014 Jan 28:jc20132378. Epub ahead of print
PMID: 24471563, PMCID: PMC4010688

Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process.
Caudle KE, Klein TE, Hoffman JM, Müller DJ, Whirl-Carrillo M, Gong L, McDonagh EM, Sangkuhl K, Thorn CF, Schwab M, Agunder JA, Freimuth RR, Huser V, Lee MT, Iwuchukwu OF, Crews KR, Scott SA, Wadelius M, Swen JJ, Tyndale RF, Stein CM, Roden D, Relling MV, Williams MS, Johnson SG.
Curr Drug Metab. 2014 Jan 30. Epub ahead of print
PMID: 24479687, PMCID: PMC3977533

A prospective study on drug monitoring of PEGasparaginase and Erwinia asparaginase and asparaginase antibodies in pediatric acute lymphoblastic leukemia.
Tong WH, Pieters R, Kaspers GJ, Te Loo DM, Bierings MB, van den Bos C, Kollen WJ, Hop WC, Lanvers-Kaminsky C, Relling MV, Tissing WJ, van der Sluis IM.
Blood. 2014 Jan 21. Epub ahead of print
PMID: 24449211, PMCID: PMC3968389

Identifying druggable targets by protein microenvironments matching: application to transcription factors.
Liu T, Altman RB.
CPT Pharmacometrics Syst Pharmacol. 2014 Jan 22;3:e93. doi: 10.1038/psp.2013.66.
PMID: 24452614, PMCID: PMC3910014

Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients.
Wang LZ, Ramírez J, Yeo W, Chan MY, Thuya WL, Lau JY, Wan SC, Wong AL, Zee YK, Lim R, Lee SC, Ho PC, Lee HS, Chan A, Ansher S, Ratain MJ, Goh BC.
PLoS One. 2014 Jan 13;9(1). doi: 10.1371/annotation/df796504-a2ea-4807-a412-85985bb2550b. eCollection 2014 Jan 13.
PMID: 23382909, PMCID: PMC3559838

Building the next generation of quantitative biologists.
Pattin KA, Greene AC, Altman RB, Hunter LE, Ross DA, Foster JA, Moore JH.
Pac Symp Biocomput. 2014;19:417-21.
PMID: 24297567, PMCID: PMC3935419

 

Publications from 2013 

December 2013Back to top

Association of abstinence-induced alterations in working memory function and COMT genotype in smokers.
Ashare RL, Valdez JN, Ruparel K, Albelda B, Hopson RD, Keefe JR, Loughead J, Lerman C.
Psychopharmacology (Berl). 2013 Dec;230(4):653-62. doi: 10.1007/s00213-013-3197-3. Epub 2013 Jul 5.
PMID: 23828159, PMCID: PMC3840089

Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data.
Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM.
PLoS One. 2013 Dec 12;8(12):e81503. doi: 10.1371/journal.pone.0081503. eCollection 2013.
PMID: 24349080, PMCID: PMC3861317

Quantifying missing heritability at known GWAS loci.
Gusev A, Bhatia G, Zaitlen N, Vilhjalmsson BJ, Diogo D, Stahl EA, Gregersen PK, Worthington J, Klareskog L, Raychaudhuri S, Plenge RM, Pasaniuc B, Price AL.
PLoS Genet. 2013;9(12):e1003993. doi: 10.1371/journal.pgen.1003993. Epub 2013 Dec 26.
PMID: 24385918, PMCID: PMC3873246

Low frequency variants, collapsed based on biological knowledge, uncover complexity of population stratification in 1000 genomes project data.
Moore CB, Wallace JR, Wolfe DJ, Frase AT, Pendergrass SA, Weiss KM, Ritchie MD.
PLoS Genet. 2013;9(12):e1003959. doi: 10.1371/journal.pgen.1003959. Epub 2013 Dec 26.
PMID: 24385916, PMCID: PMC3873241

Using chromatin marks to interpret and localize genetic associations to complex human traits and diseases.
Trynka G, Raychaudhuri S.
Curr Opin Genet Dev. 2013 Dec;23(6):635-41. doi: 10.1016/j.gde.2013.10.009. Epub 2013 Nov 25. Review.
PMID: 24287333, PMCID: PMC4073234

Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study.
Wang J, Carvajal-Carmona LG, Chu JH, Zauber AG; APC Trial Collaborators, Kubo M, Matsuda K, Dunlop M, Houlston RS, Sieber O, Lipton L, Gibbs P, Martin NG, Montgomery GW, Young J, Baird PN, Ratain MJ, Nakamura Y, Weiss ST, Tomlinson I, Bertagnolli MM.
Clin Cancer Res. 2013 Dec 1;19(23):6430-7. doi: 10.1158/1078-0432.CCR-13-0550. Epub 2013 Oct 1.
PMID: 24084763, PMCID: PMC4037290

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data.
Denny JC, Bastarache L, Ritchie MD, Carroll RJ, Zink R, Mosley JD, Field JR, Pulley JM, Ramirez AH, Bowton E, Basford MA, Carrell DS, Peissig PL, Kho AN, Pacheco JA, Rasmussen LV, Crosslin DR, Crane PK, Pathak J, Bielinski SJ, Pendergrass SA, Xu H, Hindorff LA, Li R, Manolio TA, Chute CG, Chisholm RL, Larson EB, Jarvik GP, Brilliant MH, McCarty CA, Kullo IJ, Haines JL, Crawford DC, Masys DR, Roden DM.
Nat Biotechnol. 2013 Dec;31(12):1102-10.
PMID: 24270849, PMCID: PMC3969265

PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 8.
Aquilante CL, Niemi M, Gong L, Altman RB, Klein TE.
Pharmacogenet Genomics. 2013 Dec;23(12):721-8. doi: 10.1097/FPC.0b013e3283653b27. Review. No abstract available.
PMID: 23962911, PMCID: PMC4038626

TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation.
Liang JJ, Geske JR, Boilson BA, Frantz RP, Edwards BS, Kushwaha SS, Kremers WK, Weinshilboum RM, Pereira NL.
Pharmacogenet Genomics. 2013 Dec;23(12):658-65. doi: 10.1097/FPC.0000000000000005.
PMID: 24121523, PMCID: PMC3894785

Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data.
McAllister K, Yarwood A, Bowes J, Orozco G, Viatte S, Diogo D, Hocking LJ, Steer S, Wordsworth P, Wilson AG, Morgan AW; UK Rheumatoid Arthritis Genetics Consortium; Rheumatoid Arthritis Consortium International, Kremer JM, Pappas D, Gregersen P, Klareskog L, Plenge R, Barton A, Greenberg J, Worthington J, Eyre S.
Arthritis Rheum. 2013 Dec;65(12):3058-62. doi: 10.1002/art.38183.
PMID: 24022229, PMCID: PMC4034583

Common variants in Mendelian kidney disease genes and their association with renal function.
Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha CM, Pattaro C, de Andrade M, Chasman DI, Teumer A, Endlich K, Olden M, Chen MH, Tin A, Kim YJ, Taliun D, Li M, Feitosa M, Gorski M, Yang Q, Hundertmark C, Foster MC, Glazer N, Isaacs A, Rao M, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Couraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Hofer E, Hu F, Demirkan A, Oostra BA, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Döring A, Wichmann HE, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Stengel B, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Colhoun H, Doney A, Robino A, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo M, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, van Duijn CM, Borecki I, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker PM, Bochud M, Heid IM, Siscovick DS, Fox CS, Kao WL, Böger CA.
J Am Soc Nephrol. 2013 Dec;24(12):2105-17. doi: 10.1681/ASN.2012100983. Epub 2013 Sep 12.
PMID: 24029420, PMCID: PMC3839542

Identifying phenotypic signatures of neuropsychiatric disorders from electronic medical records.
Lyalina S, Percha B, LePendu P, Iyer SV, Altman RB, Shah NH.
J Am Med Inform Assoc. 2013 Dec;20(e2):e297-305. doi: 10.1136/amiajnl-2013-001933. Epub 2013 Aug 16.
PMID: 23956017, PMCID: PMC3861917

Challenges in interpreting the evidence for genetic predictors of ototoxicity.
Ratain MJ, Cox NJ, Henderson TO.
Clin Pharmacol Ther. 2013 Dec;94(6):631-5. doi: 10.1038/clpt.2013.178.
PMID: 24241639

Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing.
Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M.
Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29.
PMID: 23988873, PMCID: PMC3831181

Genetic and pharmacokinetic determinants of response to transdermal nicotine in white, black, and Asian nonsmokers.
Dempsey DA, St Helen G, Jacob P 3rd, Tyndale RF, Benowitz NL.
Clin Pharmacol Ther. 2013 Dec;94(6):687-94. doi: 10.1038/clpt.2013.159. Epub 2013 Aug 9.
PMID: 23933970, PMCID: PMC3834081

Pharmacogenomics of acute lymphoid leukemia: new insights into treatment toxicity and efficacy.
Relling MV, Ramsey LB.
Hematology Am Soc Hematol Educ Program. 2013;2013:126-30. doi: 10.1182/asheducation-2013.1.126.
PMID: 24319173

Genomic analyses with biofilter 2.0: knowledge driven filtering, annotation, and model development.
Pendergrass SA, Frase A, Wallace J, Wolfe D, Katiyar N, Moore C, Ritchie MD.
BioData Min. 2013 Dec 30;6(1):25. Epub ahead of print
PMID: 24378202, PMCID: PMC3917600

Risk, reward, and the double-edged sword: perspectives on pharmacogenetic research and clinical testing among Alaska Native people.
Shaw JL, Robinson R, Starks H, Burke W, Dillard DA.
Am J Public Health. 2013 Dec;103(12):2220-5. doi: 10.2105/AJPH.2013.301596. Epub 2013 Oct 17.
PMID: 24134351, PMCID: PMC3828986

ATHENA: Identifying interactions between different levels of genomic data associated with cancer clinical outcomes using grammatical evolution neural network.
Kim D, Li R, Dudek SM, Ritchie MD.
BioData Min. 2013 Dec 20;6(1):23. Epub ahead of print
PMID: 24359638, PMCID: PMC3912499

Using systems approaches to address challenges for clinical implementation of pharmacogenomics.
Karnes JH, Driest SV, Bowton EA, Weeke PE, Mosley JD, Peterson JF, Denny JC, Roden DM.
Wiley Interdiscip Rev Syst Biol Med. 2013 Dec 6. doi: 10.1002/wsbm.1255. Epub 2013 Dec 6. Review.
PMID: 24319008, PMCID: PMC3944797

 

November 2013Back to top

Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes.
Behr ER, Ritchie MD, Tanaka T, Kääb S, Crawford DC, Nicoletti P, Floratos A, Sinner MF, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Zumhagen S, Guicheney P, Bishopric NH, Marshall V, Shakir S, Dalageorgou C, Bevan S, Jamshidi Y, Bastiaenen R, Myerburg RJ, Schott JJ, Camm AJ, Steinbeck G, Norris K, Altman RB, Tatonetti NP, Jeffery S, Kubo M, Nakamura Y, Shen Y, George AL Jr, Roden DM.
PLoS One. 2013 Nov 6;8(11):e78511. doi: 10.1371/journal.pone.0078511. eCollection 2013.
PMID: 24223155, PMCID: PMC3819377

Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls.
Falcone M, Smith RM, Chenoweth MJ, Kumar Bhattacharjee A, Kelsoe JR, Tyndale RF, Lerman C; Pharmacogenomics Research Network Central Nervous System Working Group.
Neuropsychopharmacology. 2013 Nov;38(12):2327-37. doi: 10.1038/npp.2013.152. Epub 2013 Jun 24. Review.
PMID: 23793356, PMCID: PMC3799069

Processes and preliminary outputs for identification of actionable genes as incidental findings in genomic sequence data in the Clinical Sequencing Exploratory Research Consortium.
Berg JS, Amendola LM, Eng C, Van Allen E, Gray SW, Wagle N, Rehm HL, DeChene ET, Dulik MC, Hisama FM, Burke W, Spinner NB, Garraway L, Green RC, Plon S, Evans JP, Jarvik GP; Members of the CSER Actionability and Return of Results Working Group.
Genet Med. 2013 Nov;15(11):860-7. doi: 10.1038/gim.2013.133. Epub 2013 Oct 24. Review. Erratum in: Genet Med. 2014 Feb;16(2):203.
PMID: 24195999, PMCID: PMC3935342

Recommendations for returning genomic incidental findings? We need to talk!
Burke W, Matheny Antommaria AH, Bennett R, Botkin J, Clayton EW, Henderson GE, Holm IA, Jarvik GP, Khoury MJ, Knoppers BM, Press NA, Ross LF, Rothstein MA, Saal H, Uhlmann WR, Wilfond B, Wolf SM, Zimmern R.
Genet Med. 2013 Nov;15(11):854-9. doi: 10.1038/gim.2013.113. Epub 2013 Aug 1. Review.
PMID: 23907645, PMCID: PMC3832423

Return of incidental findings in genomic medicine: measuring what patients value--development of an instrument to measure preferences for information from next-generation testing (IMPRINT).
Bennette CS, Trinidad SB, Fullerton SM, Patrick D, Amendola L, Burke W, Hisama FM, Jarvik GP, Regier DA, Veenstra DL.
Genet Med. 2013 Nov;15(11):873-81. doi: 10.1038/gim.2013.63. Epub 2013 May 30.
PMID: 23722871, PMCID: PMC3823641

Inferring the semantic relationships of words within an ontology using random indexing: applications to pharmacogenomics.
Percha B, Altman RB.
AMIA Annu Symp Proc. 2013 Nov 16;2013:1123-32. eCollection 2013.
PMID: 24551397, PMCID: PMC3900134

PharmGKB summary: tamoxifen pathway, pharmacokinetics.
Klein DJ, Thorn CF, Desta Z, Flockhart DA, Altman RB, Klein TE.
Pharmacogenet Genomics. 2013 Nov;23(11):643-7. doi: 10.1097/FPC.0b013e3283656bc1. Review. No abstract available.
PMID: 23962908, PMCID: PMC4084801

PharmGKB summary: very important pharmacogene information for the epidermal growth factor receptor.
Hodoglugil U, Carrillo MW, Hebert JM, Karachaliou N, Rosell RC, Altman RB, Klein TE.
Pharmacogenet Genomics. 2013 Nov;23(11):636-42. doi: 10.1097/FPC.0b013e3283655091. Review. No abstract available.
PMID: 23962910, PMCID: PMC3966564

Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use.
Tse SM, Li L, Butler MG, Fung V, Kharbanda EO, Larkin EK, Vollmer WM, Miroshnik I, Rusinak D, Weiss ST, Lieu T, Wu AC.
Am J Respir Crit Care Med. 2013 Nov 1;188(9):1076-82. doi: 10.1164/rccm.201306-1017OC.
PMID: 24093599, PMCID: PMC3863744

Pharmacometabolomics of statin response.
Krauss RM, Zhu H, Kaddurah-Daouk R.
Clin Pharmacol Ther. 2013 Nov;94(5):562-5. doi: 10.1038/clpt.2013.164. Epub 2013 Aug 14. Review.
PMID: 23945822, PMCID: PMC4055080

Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.
Wu AC, Himes BE, Lasky-Su J, Litonjua A, Peters SP, Lima J, Kubo M, Tamari M, Nakamura Y, Qiu W, Weiss ST, Tantisira K.
J Allergy Clin Immunol. 2013 Nov 23. doi:pii: S0091-6749(13)01486-3. 10.1016/j.jaci.2013.09.037. Epub ahead of print
PMID: 24280104, PMCID: PMC3943570

Genome-wide association analysis identifies 3 common variants predisposing to brugada syndrome, a rare disease with high risk of sudden cardiac death.
Barc J, Bezzina C, Mizusawa Y, Remme C, Gourraud J, Verkerk A, Schwartz P, Guicheney P, Antzelevitch C, Schulze-Bahr E, Behr E, Tfelt-Hanson J, Kaab S, Watanabe H, Horie M, Makita N, Shimizu W, Roden D, Christoffels V, Gessler M, Wilde A, Probst V, Schott J, Dina C, Redon R.
Heart Rhythm. 2013 Nov;10(11):1743-4. doi: 10.1016/j.hrthm.2013.09.020. Epub 2013 Oct 24.
PMID: 24210383

Towards Quantitation of the Effects of Renal Impairment and Probenecid Inhibition on Kidney Uptake and Efflux Transporters, Using Physiologically Based Pharmacokinetic Modelling and Simulations.
Hsu V, de L T Vieira M, Zhao P, Zhang L, Zheng JH, Nordmark A, Berglund EG, Giacomini KM, Huang SM.
Clin Pharmacokinet. 2013 Nov 9. Epub ahead of print
PMID: 24214317, PMCID: PMC3927056

Vitamin D related genes in lung development and asthma pathogenesis.
Kho AT, Sharma S, Qiu W, Gaedigk R, Klanderman B, Niu S, Anderson C, Leeder JS, Weiss ST, Tantisira KG.
BMC Med Genomics. 2013 Nov 5;6(1):47. Epub ahead of print
PMID: 24188128

Eugenics to medical genetics.
Burke W.
Nat Med. 2013 Nov;19(11):1366. doi: 10.1038/nm.3315. No abstract available.
PMID: 24202380

PharmGKB: the Pharmacogenomics Knowledge Base.
Thorn CF, Klein TE, Altman RB.
Methods Mol Biol. 2013;1015:311-20. doi: 10.1007/978-1-62703-435-7_20.
PMID: 23824865, PMCID: PMC4084821

 

October 2013Back to top

Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study.
McDonough CW, Gillis NK, Alsultan A, Chang SW, Kawaguchi-Suzuki M, Lang JE, Shahin MH, Buford TW, El Rouby NM, Sá AC, Langaee TY, Gums JG, Chapman AB, Cooper-DeHoff RM, Turner ST, Gong Y, Johnson JA.
PLoS One. 2013 Oct 7;8(10):e76984. doi: 10.1371/journal.pone.0076984. eCollection 2013.
PMID: 24116192, PMCID: PMC3792156

Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity.
McWhinney-Glass S, Winham SJ, Hertz DL, Yen Revollo J, Paul J, He Y, Brown R, Motsinger-Reif AA, McLeod HL; Scottish Gynaecological Clinical Trials Group.
Clin Cancer Res. 2013 Oct 15;19(20):5769-76. doi: 10.1158/1078-0432.CCR-13-0774. Epub 2013 Aug 20.
PMID: 23963862, PMCID: PMC3798385

Regulation of microRNA expression by rifampin in human hepatocytes.
Ramamoorthy A, Liu Y, Philips S, Desta Z, Lin H, Goswami C, Gaedigk A, Li L, Flockhart DA, Skaar TC.
Drug Metab Dispos. 2013 Oct;41(10):1763-8. doi: 10.1124/dmd.113.052886. Epub 2013 Aug 9.
PMID: 23935064, PMCID: PMC3781376

Electronic health record design and implementation for pharmacogenomics: a local perspective.
Peterson JF, Bowton E, Field JR, Beller M, Mitchell J, Schildcrout J, Gregg W, Johnson K, Jirjis JN, Roden DM, Pulley JM, Denny JC.
Genet Med. 2013 Oct;15(10):833-41. doi: 10.1038/gim.2013.109. Epub 2013 Sep 5.
PMID: 24009000, PMCID: PMC3925979

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future.
Gottesman O, Kuivaniemi H, Tromp G, Faucett WA, Li R, Manolio TA, Sanderson SC, Kannry J, Zinberg R, Basford MA, Brilliant M, Carey DJ, Chisholm RL, Chute CG, Connolly JJ, Crosslin D, Denny JC, Gallego CJ, Haines JL, Hakonarson H, Harley J, Jarvik GP, Kohane I, Kullo IJ, Larson EB, McCarty C, Ritchie MD, Roden DM, Smith ME, Böttinger EP, Williams MS; eMERGE Network.
Genet Med. 2013 Oct;15(10):761-71. doi: 10.1038/gim.2013.72. Epub 2013 Jun 6. Review.
PMID: 23743551, PMCID: PMC3795928

PharmGKB summary: cyclosporine and tacrolimus pathways.
Barbarino JM, Staatz CE, Venkataramanan R, Klein TE, Altman RB.
Pharmacogenet Genomics. 2013 Oct;23(10):563-85. doi: 10.1097/FPC.0b013e328364db84. Review. No abstract available.
PMID: 23922006, PMCID: PMC4119065

Aromatase inhibitor-induced modulation of breast density: clinical and genetic effects.
Henry NL, Chan HP, Dantzer J, Goswami CP, Li L, Skaar TC, Rae JM, Desta Z, Khouri N, Pinsky R, Oesterreich S, Zhou C, Hadjiiski L, Philips S, Robarge J, Nguyen AT, Storniolo AM, Flockhart DA, Hayes DF, Helvie MA, Stearns V.
Br J Cancer. 2013 Oct 29;109(9):2331-9. doi: 10.1038/bjc.2013.587. Epub 2013 Oct 1.
PMID: 24084768, PMCID: PMC3817329

Applied Pharmacogenomics in Cardiovascular Medicine.
Weeke P, Roden DM.
Annu Rev Med. 2014;65:81-94. doi: 10.1146/annurev-med-101712-122545. Epub 2013 Oct 2. Review.
PMID: 24111889, PMCID: PMC4081861

Visualizing genomic information across chromosomes with PhenoGram.
Wolfe D, Dudek S, Ritchie MD, Pendergrass SA.
BioData Min. 2013 Oct 16;6(1):18. Epub ahead of print
PMID: 24131735, PMCID: PMC4015356

Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes.
Karnes JH, Gong Y, Pacanowski MA, McDonough CW, Arwood MJ, Langaee TY, Pepine CJ, Johnson JA, Cooper-Dehoff RM.
Pharmacogenet Genomics. 2013 Oct 14. Epub ahead of print
PMID: 24128935, PMCID: PMC3893755

PROX1 Gene Variant is Associated with Fasting Glucose Change After Antihypertensive Treatment.
Gong Y, McDonough CW, Beitelshees AL, Karnes JH, O'Connell JR, Turner ST, Chapman AB, Gums JG, Bailey KR, Boerwinkle E, Johnson JA, Cooper-Dehoff RM.
Pharmacotherapy. 2013 Oct 9. doi: 10.1002/phar.1355. Epub ahead of print
PMID: 24122840, PMCID: PMC3945213

Candidate Gene Approach to Identifying Rare Genetic Variants Associated with Lone Atrial Fibrillation.
Weeke P, Parvez B, Blair M, Short L, Ingram C, Kucera G, Stubblefield T, Roden DM, Darbar D.
Heart Rhythm. 2013 Oct 10. doi:pii: S1547-5271(13)01164-8. 10.1016/j.hrthm.2013.10.025. Epub ahead of print
PMID: 24120998, PMCID: PMC3947369

The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons.
Parker DJ, Gardiner A, Neville MC, Ritchie MG, Goodwin SF.
Heredity (Edinb). 2013 Oct 23. doi: 10.1038/hdy.2013.106. Epub ahead of print
PMID: 24149653, PMCID: PMC3931162

Pathway analysis of genome-wide data improves warfarin dose prediction.
Daneshjou R, Tatonetti NP, Karczewski KJ, Sagreiya H, Bourgeois S, Drozda K, Burmester JK, Tsunoda T, Nakamura Y, Kubo M, Tector M, Limdi NA, Cavallari LH, Perera M, Johnson JA, Klein TE, Altman RB.
BMC Genomics. 2013;14 Suppl 3:S11. doi: 10.1186/1471-2164-14-S3-S11. Epub 2013 May 28.
PMID: 23819817, PMCID: PMC3829086

Collective judgment predicts disease-associated single nucleotide variants.
Capriotti E, Altman RB, Bromberg Y.
BMC Genomics. 2013;14 Suppl 3:S2. doi: 10.1186/1471-2164-14-S3-S2. Epub 2013 May 28.
PMID: 23819846, PMCID: PMC3839641

WS-SNPs&GO: a web server for predicting the deleterious effect of human protein variants using functional annotation.
Capriotti E, Calabrese R, Fariselli P, Martelli PL, Altman RB, Casadio R.
BMC Genomics. 2013;14 Suppl 3:S6. doi: 10.1186/1471-2164-14-S3-S6. Epub 2013 May 28.
PMID: 23819482, PMCID: PMC3665478

A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk.
Yarwood A, Han B, Raychaudhuri S, Bowes J, Lunt M, Pappas DA, Kremer J, Greenberg JD, Plenge R; Rheumatoid Arthritis Consortium International (RACI), Worthington J, Barton A, Eyre S.
Ann Rheum Dis. 2013 Oct 3. doi: 10.1136/annrheumdis-2013-204133. Epub ahead of print
PMID: 24092415

Impact of genotype-guided dosing on anticoagulation visits for adults starting warfarin: a randomized controlled trial.
Jonas DE, Evans JP, McLeod HL, Brode S, Lange LA, Young ML, Shilliday BB, Bardsley MM, Swinton-Jenkins NJ, Weck KE.
Pharmacogenomics. 2013 Oct;14(13):1593-1603.
PMID: 24088130

September 2013Back to top

A method for inferring medical diagnoses from patient similarities.
Gottlieb A, Stein GY, Ruppin E, Altman RB, Sharan R.
BMC Med. 2013 Sep 2;11:194. doi: 10.1186/1741-7015-11-194.
PMID: 24004670, PMCID: PMC3844462 

Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder.
Greenwood TA, Badner JA, Byerley W, Keck PE, McElroy SL, Remick RA, Sadovnick AD, Akiskal HS, Kelsoe JR.
J Affect Disord. 2013 Sep 25;150(3):1031-40. doi: 10.1016/j.jad.2013.05.035. Epub 2013 Jun 10.
PMID: 23759419, PMCID: PMC3759543

The CYP2C19*17 variant is not independently associated with clopidogrel response.
Lewis JP, Stephens SH, Horenstein RB, O'Connell JR, Ryan K, Peer CJ, Figg WD, Spencer SD, Pacanowski MA, Mitchell BD, Shuldiner AR.
J Thromb Haemost. 2013 Sep;11(9):1640-6. doi: 10.1111/jth.12342.
PMID: 23809542, PMCID: PMC3773276

Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study.
Carlson CS, Matise TC, North KE, Haiman CA, Fesinmeyer MD, Buyske S, Schumacher FR, Peters U, Franceschini N, Ritchie MD, Duggan DJ, Spencer KL, Dumitrescu L, Eaton CB, Thomas F, Young A, Carty C, Heiss G, Le Marchand L, Crawford DC, Hindorff LA, Kooperberg CL; PAGE Consortium.
PLoS Biol. 2013 Sep;11(9):e1001661. doi: 10.1371/journal.pbio.1001661. Epub 2013 Sep 17.
PMID: 24068893, PMCID: PMC3775722

Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8).
Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM.
J Pharm Sci. 2013 Sep;102(9):3451-7. doi: 10.1002/jps.23581. Epub 2013 May 6.
PMID: 23649425, PMCID: PMC4151246

Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example.
Sadee W.
J Pharm Sci. 2013 Sep;102(9):2924-9. doi: 10.1002/jps.23483. Epub 2013 Feb 21. Review.
PMID: 23436703

Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema.
Pare G, Kubo M, Byrd JB, McCarty CA, Woodard-Grice A, Teo KK, Anand SS, Zuvich RL, Bradford Y, Ross S, Nakamura Y, Ritchie M, Brown NJ.
Pharmacogenet Genomics. 2013 Sep;23(9):470-8. doi: 10.1097/FPC.0b013e328363c137.
PMID: 23838604, PMCID: PMC3904664

PharmGKB summary: methylene blue pathway.
McDonagh EM, Bautista JM, Youngster I, Altman RB, Klein TE.
Pharmacogenet Genomics. 2013 Sep;23(9):498-508. doi: 10.1097/FPC.0b013e32836498f4. No abstract available.
PMID: 23913015, PMCID: PMC4091817

Erratum to: The success of pharmacogenomics in moving genetic association studies from bench to bedside: study design and implementation of precision medicine in the post-GWAS era.
Ritchie MD.
Hum Genet. 2013 Sep 17. Epub ahead of print No abstract available.
PMCID: PMC3432217

Evaluation of utility of pharmacokinetic studies in phase I trials of two oncology drugs.
Wu K, House L, Ramirez J, Seminerio MJ, Ratain MJ.
Clin Cancer Res. 2013 Sep 20. Epub ahead of print
PMID: 24056785, PMCID: PMC3832109

Actionable, Pathogenic Incidental Findings in 1,000 Participants' Exomes.
Dorschner MO, Amendola LM, Turner EH, Robertson PD, Shirts BH, Gallego CJ, Bennett RL, Jones KL, Tokita MJ, Bennett JT, Kim JH, Rosenthal EA, Kim DS; National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing Project, Tabor HK, Bamshad MJ, Motulsky AG, Scott CR, Pritchard CC, Walsh T, Burke W, Raskind WH, Byers P, Hisama FM, Nickerson DA, Jarvik GP.
Am J Hum Genet. 2013 Sep 17. doi:pii: S0002-9297(13)00381-9. 10.1016/j.ajhg.2013.08.006. Epub ahead of print
PMID: 24055113, PMCID: PMC3791261

PS3-4: Genetic Risk Factors for Major Bleeding in Warfarin Patients in a Community Setting.
Roth J, Boudreau D, Fujii M, Farin F, Rettie A, Thummel K, Veenstra D.
Clin Med Res. 2013 Sep;11(3):148.
PMCID: PMC3788436 

Cholesteryl ester transfer protein (CETP) polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events.
Leusink M, Onland-Moret NC, Asselbergs FW, Ding B, Kotti S, van Zuydam NR, Papp AC, Danchin N, Donnelly L, Morris AD, Chasman DI, Doevendans PA, Klungel OH, Ridker PM, van Gilst WH, Simon T, Nyberg F, Palmer CN, Sadee W, van der Harst P, de Bakker PI, de Boer A, Verstuyft C, Maitland-van der Zee AH.
Clin Pharmacol Ther. 2013 Sep 30. doi: 10.1038/clpt.2013.194. Epub ahead of print
PMID: 24080640

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.
Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Lima JJ, Irvin CG, Peters SP, Kubo M, Tamari M, Nakamura Y, Litonjua AA, Tantisira KG, Raby BA, Bleecker ER, Meyers DA, London SJ, Barnes KC, Gilliland FD, Williams LK, Burchard EG, Nicolae DL, Ober C, DeMeo DL, Silverman EK, Paigen B, Churchill G, Shapiro SD, Weiss ST.
PLoS One. 2013;8(2):e56179. doi: 10.1371/journal.pone.0056179. Epub 2013 Feb 14.
PMID: 23457522, PMCID: PMC3572953

Stroke Genetics Network (SiGN) Study: Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes.
Meschia JF, Arnett DK, Ay H, Brown RD Jr, Benavente OR, Cole JW, de Bakker PI, Dichgans M, Doheny KF, Fornage M, Grewal RP, Gwinn K, Jern C, Conde JJ, Johnson JA, Jood K, Laurie CC, Lee JM, Lindgren A, Markus HS, McArdle PF, McClure LA, Mitchell BD, Schmidt R, Rexrode KM, Rich SS, Rosand J, Rothwell PM, Rundek T, Sacco RL, Sharma P, Shuldiner AR, Slowik A, Wassertheil-Smoller S, Sudlow C, Thijs VN, Woo D, Worrall BB, Wu O, Kittner SJ; on behalf of the NINDS SiGN Study.
Stroke. 2013 Sep 12. Epub ahead of print
PMID: 24021684, PMCID: PMC4056331

Using molecular features of xenobiotics to predict hepatic gene expression response.
Fernald GH, Altman RB.
J Chem Inf Model. 2013 Sep 6. Epub ahead of print
PMID: 24010729, PMCID: PMC3810861

Are drug labels static or dynamic?
Seminerio MJ, Ratain MJ.
Clin Pharmacol Ther. 2013 Sep;94(3):302-4. doi: 10.1038/clpt.2013.109.
PMID: 23963217

August 2013Back to top

Seeking Genomic Knowledge: The Case for Clinical Restraint.
Burke W, Trinidad SB, Clayton EW.
Hastings Law J. 2013 Aug 1;64(6):1650-1664.
PMID: 24688162, PMCID: PMC3969739

Managing incidental genomic findings: legal obligations of clinicians.
Clayton EW, Haga S, Kuszler P, Bane E, Shutske K, Burke W.
Genet Med. 2013 Aug;15(8):624-9. doi: 10.1038/gim.2013.7. Epub 2013 Feb 28.
PMID: 23448723, PMCID: PMC3805501

Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma.
Ellsworth KA, Eckloff BW, Li L, Moon I, Fridley BL, Jenkins GD, Carlson E, Brisbin A, Abo R, Bamlet W, Petersen G, Wieben ED, Wang L.
PLoS One. 2013 Aug 1;8(8):e70216. doi: 10.1371/journal.pone.0070216. Print 2013.
PMID: 23936393, PMCID: PMC3731355

Unmet needs in preventing adverse drug-drug interactions.
Ratain MJ, Seminerio MJ.
Clin Adv Hematol Oncol. 2013 Aug;11(8):520-1. No abstract available.
PMID: 24518424, PMCID: PMC3880605

Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y, Burkley BM, Desnick RJ, Halperin JL, Khalifa SI, Langaee TY, Lubitz SA, Nutescu EA, Oetjens M, Shahin MH, Patel SR, Sagreiya H, Tector M, Weck KE, Rieder MJ, Scott SA, Wu AH, Burmester JK, Wadelius M, Deloukas P, Wagner MJ, Mushiroda T, Kubo M, Roden DM, Cox NJ, Altman RB, Klein TE, Nakamura Y, Johnson JA.
Lancet. 2013 Aug 31;382(9894):790-6. doi: 10.1016/S0140-6736(13)60681-9. Epub 2013 Jun 5.
PMID: 23755828, PMCID: PMC3759580

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.
Umicevic Mirkov M, Cui J, Vermeulen SH, Stahl EA, Toonen EJ, Makkinje RR, Lee AT, Huizinga TW, Allaart R, Barton A, Mariette X, Miceli CR, Criswell LA, Tak PP, de Vries N, Saevarsdottir S, Padyukov L, Bridges SL, van Schaardenburg DJ, Jansen TL, Dutmer EA, van de Laar MA, Barrera P, Radstake TR, van Riel PL, Scheffer H, Franke B, Brunner HG, Plenge RM, Gregersen PK, Guchelaar HJ, Coenen MJ.
Ann Rheum Dis. 2013 Aug;72(8):1375-81. doi: 10.1136/annrheumdis-2012-202405. Epub 2012 Dec 11.
PMID: 23233654, PMCID: PMC4169706

Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments.
Pauley JL, Panetta JC, Crews KR, Pei D, Cheng C, McCormick J, Howard SC, Sandlund JT, Jeha S, Ribeiro R, Rubnitz J, Pui CH, Evans WE, Relling MV.
Cancer Chemother Pharmacol. 2013 Aug;72(2):369-78. doi: 10.1007/s00280-013-2206-x. Epub 2013 Jun 13.
PMID: 23760811, PMCID: PMC3719000

CYP2D6 genotype and tamoxifen activity: understanding interstudy variability in methodological quality.
Ratain MJ, Nakamura Y, Cox NJ.
Clin Pharmacol Ther. 2013 Aug;94(2):185-7. doi: 10.1038/clpt.2013.66. No abstract available.
PMID: 23872831, PMCID: PMC3782290

Genomic medicine, precision medicine, personalized medicine: what's in a name?
Roden DM, Tyndale RF.
Clin Pharmacol Ther. 2013 Aug;94(2):169-72. doi: 10.1038/clpt.2013.101.
PMID: 23872826, PMCID: PMC3965175

The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer.
Yang JJ, Lim JY, Huang J, Bass J, Wu J, Wang C, Fang J, Stewart E, Harstead EH, E S, Robinson GW, Evans WE, Pappo A, Zuo J, Relling MV, Onar-Thomas A, Gajjar A, Stewart CF.
Clin Pharmacol Ther. 2013 Aug;94(2):252-9. doi: 10.1038/clpt.2013.121. Epub 2013 Jun 11.
PMID: 23820299, PMCID: PMC3883563

Challenges in the pharmacogenomic annotation of whole genomes.
Altman RB, Whirl-Carrillo M, Klein TE.
Clin Pharmacol Ther. 2013 Aug;94(2):211-3. doi: 10.1038/clpt.2013.111. Epub 2013 May 24. No abstract available.
PMID: 23708745, PMCID: PMC4058909

Challenges in implementing genomic medicine: the Mayo Clinic Center for Individualized Medicine.
Farrugia G, Weinshilboum RM.
Clin Pharmacol Ther. 2013 Aug;94(2):204-6. doi: 10.1038/clpt.2013.52. Epub 2013 Mar 11. No abstract available.
PMID: 23588321, PMCID: PMC3909951

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.
Shuldiner AR, Relling MV, Peterson JF, Hicks JK, Freimuth RR, Sadee W, Pereira NL, Roden DM, Johnson JA, Klein TE; Pharmacogenomics Research Network Translational Pharmacogenetics Program Group, Shuldiner AR, Vesely M, Robinson SW, Ambulos N Jr, Stass SA, Kelemen MD, Brown LA, Pollin TI, Beitelshees AL, Zhao RY, Pakyz RE, Palmer K, Alestock T, O'Neill C, Maloney K, Branham A, Sewell D, Relling MV, Crews K, Hoffman J, Cross S, Haidar C, Baker D, Hicks JK, Bell G, Greeson F, Gaur A, Reiss U, Huettel A, Cheng C, Gajjar A, Pappo A, Howard S, Hudson M, Pui CH, Jeha S, Evans WE, Broeckel U, Altman RB, Gong L, Whirl-Carrillo M, Klein TE, Sadee W, Manickam K, Sweet KM, Embi PJ, Roden D, Peterson J, Denny J, Schildcrout J, Bowton E, Pulley J, Beller M, Mitchell J, Danciu I, Price L, Pereira NL, Weinshilboum R, Wang L, Johnson JA, Nelson D, Clare-Salzler M, Elsey A, Burkley B, Langaee T, Liu F, Nessl D, Dong HJ, Lesko L, Freimuth RR, Chute CG.
Clin Pharmacol Ther. 2013 Aug;94(2):207-10. doi: 10.1038/clpt.2013.59. Epub 2013 Mar 19. No abstract available.
PMID: 23588301, PMCID: PMC3720847

Common CYP2D6 Polymorphisms Affecting Alternative Splicing and Transcription: Long-range Haplotypes with Two Regulatory Variants Modulate CYP2D6 Activity.
Wang D, Poi MJ, Sun X, Gaedigk A, Leeder JS, Sadee W.
Hum Mol Genet. 2013 Aug 28. Epub ahead of print
PMID: 23985325, PMCID: PMC3857955

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisén L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kähler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landén M, Långström N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, Macintyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Mühleisen TW, Muir WJ, Müller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nöthen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnström K, Reif A, Ribasés M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zöllner S; International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Sullivan PF, Smoller JW, Kendler KS, Wray NR.
Nat Genet. 2013 Aug 11. doi: 10.1038/ng.2711. Epub ahead of print
PMID: 23933821, PMCID: PMC3800159

Standardized drug and pharmacological class network construction.
Zhu Q, Jiang G, Wang L, Chute CG.
Stud Health Technol Inform. 2013;192:1125.
PMID: 23920899, PMCID: PMC3909176

Building a Knowledge Base of Severe Adverse Drug Events Based on AERS Reporting Data Using Semantic Web Technologies.
Jiang G, Wang L, Liu H, Solbrig HR, Chute CG.
Stud Health Technol Inform. 2013;192:496-500.
PMID: 23920604

Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study.
Spencer KL, Malinowski J, Carty CL, Franceschini N, Fernández-Rhodes L, Young A, Cheng I, Ritchie MD, Haiman CA, Wilkens L, Chunyuanwu, Matise TC, Carlson CS, Brennan K, Park A, Rajkovic A, Hindorff LA, Buyske S, Crawford DC.
PLoS One. 2013;8(2):e55258. doi: 10.1371/journal.pone.0055258. Epub 2013 Feb 12.
PMID: 23424626, PMCID: PMC3570525

Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions.
Shirasaka Y, Chang SY, Grubb MF, Peng CC, Thummel KE, Isoherranen N, Rodrigues AD.
Drug Metab Dispos. 2013 Aug;41(8):1566-74. doi: 10.1124/dmd.112.049940. Epub 2013 May 30.
PMID: 23723360, PMCID: PMC3716306

Whole transcriptome RNA-Seq allelic expression in human brain.
Smith RM, Webb A, Papp AC, Newman LC, Handelman SK, Suhy A, Mascarenhas R, Oberdick J, Sadee W.
BMC Genomics. 2013 Aug 22;14:571. doi: 10.1186/1471-2164-14-571.
PMID: 23968248, PMCID: PMC3765493

Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes.
Ramirez AH, Shaffer CM, Delaney JT, Sexton DP, Levy SE, Rieder MJ, Nickerson DA, George AL Jr, Roden DM.
Pharmacogenomics J. 2013 Aug;13(4):325-9. doi: 10.1038/tpj.2012.14. Epub 2012 May 15.
PMID: 22584458, PMCID: PMC3880605

July 2013Back to top

Primary-care physicians' access to genetic specialists: an impediment to the routine use of genomic medicine?
Haga SB, Burke W, Agans R.
Genet Med. 2013 Jul;15(7):513-4. doi: 10.1038/gim.2012.168. Epub 2013 Jan 10. No abstract available.
PMID: 23306802, PMCID: PMC3731758 

Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention.
Ingle JN, Liu M, Wickerham DL, Schaid DJ, Wang L, Mushiroda T, Kubo M, Costantino JP, Vogel VG, Paik S, Goetz MP, Ames MM, Jenkins GD, Batzler A, Carlson EE, Flockhart DA, Wolmark N, Nakamura Y, Weinshilboum RM.
Cancer Discov. 2013 Jul;3(7):812-25. doi: 10.1158/2159-8290.CD-13-0038. Epub 2013 Jun 13.
PMID: 23764426, PMCID: PMC3710533

Gastric cancer pharmacogenetics: progress or old tripe?
Patel JN, Fuchs CS, Owzar K, Chen Z, McLeod HL.
Pharmacogenomics. 2013 Jul;14(9):1053-64. doi: 10.2217/pgs.13.88. Review.
PMID: 23837480

Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751.
Innocenti F, Ramírez J, Obel J, Xiong J, Mirkov S, Chiu YL, Katz DA, Carr RA, Zhang W, Das S, Adjei A, Moyer AM, Chen PX, Krivoshik A, Medina D, Gordon GB, Ratain MJ, Sahelijo L, Weinshilboum RM, Fleming GF, Bhathena A.
Pharmacogenet Genomics. 2013 Jul;23(7):374-81. doi: 10.1097/FPC.0b013e3283623e81.
PMID: 23670235, PMCID: PMC3858967

The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes.
Behr ER, January C, Schulze-Bahr E, Grace AA, Kääb S, Fiszman M, Gathers S, Buckman S, Youssef A, Pirmohamed M, Roden D.
Eur Heart J. 2013 Jul;34(26):1958-63. doi: 10.1093/eurheartj/ehs172. Epub 2012 Jul 2. No abstract available.
PMID: 22752616, PMCID: PMC3703308

Pharmacogenomics of anti-platelet and anti-coagulation therapy.
Fisch AS, Perry CG, Stephens SH, Horenstein RB, Shuldiner AR.
Curr Cardiol Rep. 2013 Jul;15(7):381. doi: 10.1007/s11886-013-0381-3. Review.
PMID: 23797323, PMCID: PMC3809070

Pharmacogenomics and cardiovascular disease.
Weeke P, Roden DM.
Curr Cardiol Rep. 2013 Jul;15(7):376. doi: 10.1007/s11886-013-0376-0. Review.
PMID: 23689943, PMCID: PMC3941471

Interplay between vitamin D and the drug metabolizing enzyme CYP3A4.
Wang Z, Schuetz EG, Xu Y, Thummel KE.
J Steroid Biochem Mol Biol. 2013 Jul;136:54-8. doi: 10.1016/j.jsbmb.2012.09.012. Epub 2012 Sep 15. Review.
PMID: 22985909, PMCID: PMC3549031

Whole Exome Sequencing Identifies a Causal RBM20 Mutation in a Large Pedigree with Familial Dilated Cardiomyopathy.
Wells QS, Becker JR, Su YR, Mosley JD, Weeke P, D'Aoust L, Ausborn NL, Ramirez AH, Pfotenhauer JP, Naftilan AJ, Markham L, Exil V, Roden DM, Hong CC.
Circ Cardiovasc Genet. 2013 Jul 16. Epub ahead of print
PMID: 23861363, PMCID: PMC3895490

Regulatory polymorphisms in CYP2C19 affecting hepatic expression.
Sanford JC, Guo Y, Sadee W, Wang D.
Drug Metabol Drug Interact. 2013;28(1):23-30. doi: 10.1515/dmdi-2012-0038.
PMID: 23412869, PMCID: PMC3755489

CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control.
Kitzmiller JP, Sullivan DM, Phelps MA, Wang D, Sadee W.
Drug Metabol Drug Interact. 2013;28(1):59-63. doi: 10.1515/dmdi-2012-0031.
PMID: 23314529, PMCID: PMC3681953

Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin.
Kreutz RP, Nystrom P, Kreutz Y, Miao J, Kovacs R, Desta Z, Flockhart DA, Jin Y.
Platelets. 2013;24(2):145-50. doi: 10.3109/09537104.2012.661107. Epub 2012 Mar 2.
PMID: 22385219, PMCID: PMC4028123

International Transporter Consortium commentary on clinically important transporter polymorphisms.
Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M; International Transporter Consortium.
Clin Pharmacol Ther. 2013 Jul;94(1):23-6. doi: 10.1038/clpt.2013.12.
PMID: 23778707

SLC classification: an update.
Schlessinger A, Yee SW, Sali A, Giacomini KM.
Clin Pharmacol Ther. 2013 Jul;94(1):19-23. doi: 10.1038/clpt.2013.73.
PMID: 23778706, PMCID: PMC4068830

PharmGKB: The Pharmacogenomics Knowledge Base.
Thorn CF, Klein TE, Altman RB.
Methods Mol Biol. 2013;1015:311-20. doi: 10.1007/978-1-62703-435-7_20.
PMID: 23824865, PMCID: PMC4084821

Transporters in drug development and clinical pharmacology.
Giacomini KM, Huang SM.
Clin Pharmacol Ther. 2013 Jul;94(1):3-9. doi: 10.1038/clpt.2013.86.
PMID: 23778703

Inhibition of Cytochrome P450 Isoforms by the E-, and Z-Isomers of Norendoxifen.
Liu J, Flockhart PJ, Lu D, Lv W, Lu WJ, Han X, Cushman M, Flockhart DA.
Drug Metab Dispos. 2013 Jul 3. Epub ahead of print
PMID: 23824607, PMCID: PMC3876808

Exome resequencing identifies potential tumor-suppressor genes that predispose to colorectal cancer.
Smith CG, Naven M, Harris R, Colley J, West H, Li N, Liu Y, Adams R, Maughan TS, Nichols L, Kaplan R, Wagner MJ, McLeod HL, Cheadle JP.
Hum Mutat. 2013 Jul;34(7):1026-34. doi: 10.1002/humu.22333. Epub 2013 May 20.
PMID: 23585368

June 2013Back to top

Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion.
Parvez B, Shoemaker MB, Muhammad R, Richardson R, Jiang L, Blair MA, Roden DM, Darbar D.
Heart Rhythm. 2013 Jun;10(6):849-55. doi: 10.1016/j.hrthm.2013.02.018. Epub 2013 Feb 19.
PMID: 23428961, PMCID: PMC3690553

Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.
McDavid A, Crane PK, Newton KM, Crosslin DR, McCormick W, Weston N, Ehrlich K, Hart E, Harrison R, Kukull WA, Rottscheit C, Peissig P, Stefanski E, McCarty CA, Zuvich RL, Ritchie MD, Haines JL, Denny JC, Schellenberg GD, de Andrade M, Kullo I, Li R, Mirel D, Crenshaw A, Bowen JD, Li G, Tsuang D, McCurry S, Teri L, Larson EB, Jarvik GP, Carlson CS.
PLoS One. 2013 Jun 10;8(6):e63481. doi: 10.1371/journal.pone.0063481. Print 2013.
PMID: 23762230, PMCID: PMC3677889

Genetic mechanisms of atrial fibrillation: impact on response to treatment.
Darbar D, Roden DM.
Nat Rev Cardiol. 2013 Jun;10(6):317-29. doi: 10.1038/nrcardio.2013.53. Epub 2013 Apr 16. Review.
PMID: 23591267, PMCID: PMC3664212

Special Section on Pharmacogenomics: recent advances and future directions.
Mushiroda T, Giacomini KM, Kubo M.
J Hum Genet. 2013 Jun;58(6):305. doi: 10.1038/jhg.2013.53. No abstract available.
PMID: 23797326

Genomic medicine: a decade of successes, challenges, and opportunities.
McCarthy JJ, McLeod HL, Ginsburg GS.
Sci Transl Med. 2013 Jun 12;5(189):189sr4. doi: 10.1126/scitranslmed.3005785. Review.
PMID: 23761042

Pharmacogenomics of anti-platelet therapy: how much evidence is enough for clinical implementation?
Perry CG, Shuldiner AR.
J Hum Genet. 2013 Jun;58(6):339-45. doi: 10.1038/jhg.2013.41. Epub 2013 May 23. Review.
PMID: 23697979, PMCID: PMC3715315

Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia.
Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C.
J Hum Genet. 2013 Jun;58(6):353-61. doi: 10.1038/jhg.2013.38. Epub 2013 May 16.
PMID: 23677058, PMCID: PMC4068832

Use of pharmacogenetics for predicting cancer prognosis and treatment exposure, response and toxicity.
Hertz DL, McLeod HL.
J Hum Genet. 2013 Jun;58(6):346-52. doi: 10.1038/jhg.2013.42. Epub 2013 May 16. Review.
PMID: 23677053

VKORC1 Asp36Tyr geographic distribution and its impact on warfarin dose requirements in Egyptians.
Shahin MH, Cavallari LH, Perera MA, Khalifa SI, Misher A, Langaee T, Patel S, Perry K, Meltzer DO, McLeod HL, Johnson JA.
Thromb Haemost. 2013 Jun;109(6):1045-50. doi: 10.1160/TH12-10-0789. Epub 2013 Mar 21.
PMID: 23571513, PMCID: PMC3712827

Pharmacogenetics of asthma controller treatment.
Mougey EB, Chen C, Tantisira KG, Blake KV, Peters SP, Wise RA, Weiss ST, Lima JJ.
Pharmacogenomics J. 2013 Jun;13(3):242-50. doi: 10.1038/tpj.2012.5. Epub 2012 Feb 28.
PMID: 22370858

Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression.
Duarte JD, Turner ST, Tran B, Chapman AB, Bailey KR, Gong Y, Gums JG, Langaee TY, Beitelshees AL, Cooper-Dehoff RM, Boerwinkle E, Johnson JA.
Pharmacogenomics J. 2013 Jun;13(3):257-63. doi: 10.1038/tpj.2012.4. Epub 2012 Feb 21.
PMID: 22350108, PMCID: PMC3360116

A genome-wide integrative study of microRNAs in human liver.
Gamazon ER, Innocenti F, Wei R, Wang L, Zhang M, Mirkov S, Ramírez J, Huang RS, Cox NJ, Ratain MJ, Liu W.
BMC Genomics. 2013 Jun 13;14:395. doi: 10.1186/1471-2164-14-395.
PMID: 23758991, PMCID: PMC3710218

CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel.
Hertz DL, Roy S, Motsinger-Reif AA, Drobish A, Clark LS, McLeod HL, Carey LA, Dees EC.
Ann Oncol. 2013 Jun;24(6):1472-8. doi: 10.1093/annonc/mdt018. Epub 2013 Feb 14.
PMID: 23413280, PMCID: PMC3660078

Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study.
Zhang L, Buzkova P, Wassel CL, Roman MJ, North KE, Crawford DC, Boston J, Brown-Gentry KD, Cole SA, Deelman E, Goodloe R, Wilson S, Heiss G, Jenny NS, Jorgensen NW, Matise TC, McClellan BE Jr, Nato AQ Jr, Ritchie MD, Franceschini N, Kao WH.
Atherosclerosis. 2013 Jun;228(2):390-9. doi: 10.1016/j.atherosclerosis.2013.02.038. Epub 2013 Mar 13.
PMID: 23587283, PMCID: PMC3717342

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, Vedantam S, Wood AR, Liang L, Steinthorsdottir V, Thorleifsson G, Dermitzakis ET, Dimas AS, Karpe F, Min JL, Nicholson G, Clegg DJ, Person T, Krohn JP, Bauer S, Buechler C, Eisinger K; DIAGRAM Consortium, Bonnefond A, Froguel P; MAGIC Investigators, Hottenga JJ, Prokopenko I, Waite LL, Harris TB, Smith AV, Shuldiner AR, McArdle WL, Caulfield MJ, Munroe PB, Grönberg H, Chen YD, Li G, Beckmann JS, Johnson T, Thorsteinsdottir U, Teder-Laving M, Khaw KT, Wareham NJ, Zhao JH, Amin N, Oostra BA, Kraja AT, Province MA, Cupples LA, Heard-Costa NL, Kaprio J, Ripatti S, Surakka I, Collins FS, Saramies J, Tuomilehto J, Jula A, Salomaa V, Erdmann J, Hengstenberg C, Loley C, Schunkert H, Lamina C, Wichmann HE, Albrecht E, Gieger C, Hicks AA, Johansson A, Pramstaller PP, Kathiresan S, Speliotes EK, Penninx B, Hartikainen AL, Jarvelin MR, Gyllensten U, Boomsma DI, Campbell H, Wilson JF, Chanock SJ, Farrall M, Goel A, Medina-Gomez C, Rivadeneira F, Estrada K, Uitterlinden AG, Hofman A, Zillikens MC, den Heijer M, Kiemeney LA, Maschio A, Hall P, Tyrer J, Teumer A, Völzke H, Kovacs P, Tönjes A, Mangino M, Spector TD, Hayward C, Rudan I, Hall AS, Samani NJ, Attwood AP, Sambrook JG, Hung J, Palmer LJ, Lokki ML, Sinisalo J, Boucher G, Huikuri H, Lorentzon M, Ohlsson C, Eklund N, Eriksson JG, Barlassina C, Rivolta C, Nolte IM, Snieder H, Van der Klauw MM, Van Vliet-Ostaptchouk JV, Gejman PV, Shi J, Jacobs KB, Wang Z, Bakker SJ, Mateo Leach I, Navis G, van der Harst P, Martin NG, Medland SE, Montgomery GW, Yang J, Chasman DI, Ridker PM, Rose LM, Lehtimäki T, Raitakari O, Absher D, Iribarren C, Basart H, Hovingh KG, Hyppönen E, Power C, Anderson D, Beilby JP, Hui J, Jolley J, Sager H, Bornstein SR, Schwarz PE, Kristiansson K, Perola M, Lindström J, Swift AJ, Uusitupa M, Atalay M, Lakka TA, Rauramaa R, Bolton JL, Fowkes G, Fraser RM, Price JF, Fischer K, Krjutå Kov K, Metspalu A, Mihailov E, Langenberg C, Luan J, Ong KK, Chines PS, Keinanen-Kiukaanniemi SM, Saaristo TE, Edkins S, Franks PW, Hallmans G, Shungin D, Morris AD, Palmer CN, Erbel R, Moebus S, Nöthen MM, Pechlivanis S, Hveem K, Narisu N, Hamsten A, Humphries SE, Strawbridge RJ, Tremoli E, Grallert H, Thorand B, Illig T, Koenig W, Müller-Nurasyid M, Peters A, Boehm BO, Kleber ME, März W, Winkelmann BR, Kuusisto J, Laakso M, Arveiler D, Cesana G, Kuulasmaa K, Virtamo J, Yarnell JW, Kuh D, Wong A, Lind L, de Faire U, Gigante B, Magnusson PK, Pedersen NL, Dedoussis G, Dimitriou M, Kolovou G, Kanoni S, Stirrups K, Bonnycastle LL, Njølstad I, Wilsgaard T, Ganna A, Rehnberg E, Hingorani A, Kivimaki M, Kumari M, Assimes TL, Barroso I, Boehnke M, Borecki IB, Deloukas P, Fox CS, Frayling T, Groop LC, Haritunians T, Hunter D, Ingelsson E, Kaplan R, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, McCarthy MI, Hirschhorn JN, Qi L, Loos RJ, Lindgren CM, North KE, Heid IM.
PLoS Genet. 2013 Jun;9(6):e1003500. doi: 10.1371/journal.pgen.1003500. Epub 2013 Jun 6.
PMID: 23754948, PMCID: PMC3674993

First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo.
Zhou K, Khokhar JY, Zhao B, Tyndale RF.
Biochem Pharmacol. 2013 Jun 15;85(12):1848-55. doi: 10.1016/j.bcp.2013.04.014. Epub 2013 Apr 23.
PMID: 23623752, PMCID: PMC3687523

Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed Pharmacogenomics.
Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R.
Clin Pharmacol Ther. 2013 Jun 11. doi: 10.1038/clpt.2013.119. Epub ahead of print
PMID: 23839601, PMCID: PMC4001726

Correction: Enabling Genomic-Phenomic Association Discovery without Sacrificing Anonymity.
Heatherly RD, Loukides G, Denny JC, Haines JL, Roden DM, Malin BA.
PLoS One. 2013 Jun 18;8(6). doi: 10.1371/annotation/db45627a-50ec-4c52-8b5f-95dec75b1c80. Print 2013.
PMID: 23825513, PMCID: PMC3691369

Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes.
Fohner A, Muzquiz LI, Austin MA, Gaedigk A, Gordon A, Thornton T, Rieder MJ, Pershouse MA, Putnam EA, Howlett K, Beatty P, Thummel KE, Woodahl EL.
Pharmacogenet Genomics. 2013 Jun 14. Epub ahead of print
PMID: 23778323, PMCID: PMC3937472

Synthesis of Mixed (E,Z)- , and (Z)-Norendoxifen with Dual Aromatase Inhibitory and Estrogen Receptor Modulatory Activities.
Lv W, Liu J, Lu D, Flockhart DA, Cushman M.
J Med Chem. 2013 Jun 3. 
PMID: 23731360, PMCID: PMC4043309

Factors Associated with Discontinuation of Bupropion and Counseling Among African American Light Smokers in a Randomized Clinical Trial.
Nollen NL, Mayo MS, Ahluwalia JS, Tyndale RF, Benowitz NL, Faseru B, Buchanan TS, Cox LS.
Ann Behav Med. 2013 Jun 4. 
PMID: 23733379, PMCID: PMC3815499

 

May 2013Back to top

Pharmacogenetics in clinical practice: how far have we come and where are we going?
Johnson JA.
Pharmacogenomics. 2013 May;14(7):835-43. doi: 10.2217/pgs.13.52.
PMID: 23651030, PMCID: PMC3697735

Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records.
Oetjens MT, Denny JC, Ritchie MD, Gillani NB, Richardson DM, Restrepo NA, Pulley JM, Dilks HH, Basford MA, Bowton E, Masys DR, Wilke RA, Roden DM, Crawford DC.
Pharmacogenomics. 2013 May;14(7):735-44. doi: 10.2217/pgs.13.64.
PMID: 23651022, PMCID: PMC3725600

Institutional profile: University of Florida and Shands Hospital Personalized Medicine Program: clinical implementation of pharmacogenetics.
Johnson JA, Elsey AR, Clare-Salzler MJ, Nessl D, Conlon M, Nelson DR.
Pharmacogenomics. 2013 May;14(7):723-6. doi: 10.2217/pgs.13.59. No abstract available.
PMID: 23651020, PMCID: PMC3684075

Response to 'Use of an algorithm for identifying hidden drug-drug interactions in adverse event reports' by Gooden et al.
Tatonetti NP, Denny JC, Altman RB.
J Am Med Inform Assoc. 2013 May;20(3):591. doi: 10.1136/amiajnl-2012-001603. Epub 2013 Jan 30. No abstract available.
PMID: 23876381, PMCID: PMC3628071

Fixed-dose capecitabine is feasible: results from a pharmacokinetic and pharmacogenetic study in metastatic breast cancer.
Rudek MA, Connolly RM, Hoskins JM, Garrett-Mayer E, Jeter SC, Armstrong DK, Fetting JH, Stearns V, Wright LA, Zhao M, Watkins SP Jr, McLeod HL, Davidson NE, Wolff AC.
Breast Cancer Res Treat. 2013 May;139(1):135-43. doi: 10.1007/s10549-013-2516-z. Epub 2013 Apr 16.
PMID: 23588952, PMCID: PMC3673300

BioBin: a bioinformatics tool for automating the binning of rare variants using publicly available biological knowledge.
Moore CB, Wallace JR, Frase AT, Pendergrass SA, Ritchie MD.
BMC Med Genomics. 2013;6 Suppl 2:S6. doi: 10.1186/1755-8794-6-S2-S6. Epub 2013 May 7.
PMID: 23819467, PMCID: PMC3654874

Clopidogrel and warfarin pharmacogenetic tests: what is the evidence for use in clinical practice?
Shahin MH, Johnson JA.
Curr Opin Cardiol. 2013 May;28(3):305-14. doi: 10.1097/HCO.0b013e32835f0bbc. Review.
PMID: 23478884, PMCID: PMC3731766

Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: implications for drug-induced osteomalacia.
Wang Z, Lin YS, Dickmann LJ, Poulton EJ, Eaton DL, Lampe JW, Shen DD, Davis CL, Shuhart MC, Thummel KE.
J Bone Miner Res. 2013 May;28(5):1101-16. doi: 10.1002/jbmr.1839.
PMID: 23212742, PMCID: PMC3609874

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.
Li G, Diogo D, Wu D, Spoonamore J, Dancik V, Franke L, Kurreeman F, Rossin EJ, Duclos G, Hartland C, Zhou X, Li K, Liu J, De Jager PL, Siminovitch KA, Zhernakova A, Raychaudhuri S, Bowes J, Eyre S, Padyukov L, Gregersen PK, Worthington J; Rheumatoid Arthritis Consortium International (RACI), Gupta N, Clemons PA, Stahl E, Tolliday N, Plenge RM.
PLoS Genet. 2013 May;9(5):e1003487. doi: 10.1371/journal.pgen.1003487. Epub 2013 May 16.
PMID: 23696745, PMCID: PMC3656093

Pharmacogenetics and cardiovascular disease--implications for personalized medicine.
Johnson JA, Cavallari LH.
Pharmacol Rev. 2013 May 17;65(3):987-1009. doi: 10.1124/pr.112.007252. Print 2013 Jul. Review.
PMID: 23686351, PMCID: PMC3698938

Web-scale pharmacovigilance: listening to signals from the crowd.
White RW, Tatonetti NP, Shah NH, Altman RB, Horvitz E.
J Am Med Inform Assoc. 2013 May 1;20(3):404-8. doi: 10.1136/amiajnl-2012-001482. Epub 2013 Mar 6.
PMID: 23467469, PMCID: PMC3628066

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge.
Plenge RM, Greenberg JD, Mangravite LM, Derry JM, Stahl EA, Coenen MJ, Barton A, Padyukov L, Klareskog L, Gregersen PK, Mariette X, Moreland LW, Bridges SL Jr, de Vries N, Huizinga TW, Guchelaar HJ; International Rheumatoid Arthritis Consortium (INTERACT), Friend SH, Stolovitzky G.
Nat Genet. 2013 May;45(5):468-9. doi: 10.1038/ng.2623. No abstract available.
PMID: 23619782, PMCID: PMC4084858

CYP2A6 Genotype but not Age Determines Cotinine Half-life in Infants and Children.
Dempsey DA, Sambol NC, Jacob P 3rd, Hoffmann E, Tyndale RF, Fuentes-Afflick E, Benowitz NL.
Clin Pharmacol Ther. 2013 May 29. doi: 10.1038/clpt.2013.114. 
PMID: 23714690, PMCID: PMC3820275

Clinical Implementation of Pharmacogenetics: More than One Gene at a Time.
Johnson JA, Klein TE, Relling MV.
Clin Pharmacol Ther. 2013 May;93(5):384-385. doi: 10.1038/clpt.2013.7.
PMID: 23598455, PMCID: PMC3716458

Genetic variation associated with circulating monocyte count in the eMERGE Network.
Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Ritchie MD, Saip A, Crawford DC, Crane PK, Newton K, Carrell DS, Gallego CJ, Nalls MA, Li R, Mirel DB, Crenshaw A, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, Smith AV, Zakai NA, Yango Q, Garcia M, Liu Y, Lumley T, Folsom AR, Reiner AP, Felix JF, Dehghan A, Wilson JG, Bis JC, Fox CS, Glazer NL, Cupples LA, Coresh J, Eiriksdottir G, Gudnason V, Bandinelli S, Frayling TM, Chakravarti A, van Duijn CM, Melzer D, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo DL, Witteman JC, Psaty BM, Ferrucci L, Harris TB, O'Donnell CJ, Ganesh SK; CHARGE Hematology Working Group, Larson EB, Carlson CS, Jarvik GP; electronic Medical Records and Genomics (eMERGE) Network.
Hum Mol Genet. 2013 May 15;22(10):2119-27. doi: 10.1093/hmg/ddt010. Epub 2013 Jan 12.
PMID: 23314186, PMCID: PMC3633369

April 2013Back to top

Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer.
Henry NL, Skaar TC, Dantzer J, Li L, Kidwell K, Gersch C, Nguyen AT, Rae JM, Desta Z, Oesterreich S, Philips S, Carpenter JS, Storniolo AM, Stearns V, Hayes DF, Flockhart DA.
Breast Cancer Res Treat. 2013 Apr;138(3):807-16. doi: 10.1007/s10549-013-2504-3. Epub 2013 Apr 2.
PMID: 23546553, PMCID: PMC3646626

Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study.
Fesinmeyer MD, North KE, Ritchie MD, Lim U, Franceschini N, Wilkens LR, Gross MD, B¿¿ková P, Glenn K, Quibrera PM, Fernández-Rhodes L, Li Q, Fowke JH, Li R, Carlson CS, Prentice RL, Kuller LH, Manson JE, Matise TC, Cole SA, Chen CT, Howard BV, Kolonel LN, Henderson BE, Monroe KR, Crawford DC, Hindorff LA, Buyske S, Haiman CA, Le Marchand L, Peters U.
Obesity (Silver Spring). 2013 Apr;21(4):835-46. doi: 10.1002/oby.20268.
PMID: 23712987, PMCID: PMC3482415

Current pharmacogenomic studies on hERG potassium channels.
He FZ, McLeod HL, Zhang W.
Trends Mol Med. 2013 Apr;19(4):227-38. doi: 10.1016/j.molmed.2012.12.006. Epub 2013 Jan 29. Review.
PMID: 23369369

Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation.
Pereira NL, Lin D, Pelleymounter L, Moon I, Stilling G, Eckloff BW, Wieben ED, Redfield MM, Burnett JC Jr, Yee VC, Weinshilboum RM.
Circ Cardiovasc Genet. 2013 Apr;6(2):201-10. doi: 10.1161/CIRCGENETICS.112.964742. Epub 2013 Mar 14.
PMID: 23493048, PMCID: PMC3685298

Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.
Lewis JP, Ryan K, O'Connell JR, Horenstein RB, Damcott CM, Gibson Q, Pollin TI, Mitchell BD, Beitelshees AL, Pakzy R, Tanner K, Parsa A, Tantry US, Bliden KP, Post WS, Faraday N, Herzog W, Gong Y, Pepine CJ, Johnson JA, Gurbel PA, Shuldiner AR.
Circ Cardiovasc Genet. 2013 Apr;6(2):184-92. doi: 10.1161/CIRCGENETICS.111.964627. Epub 2013 Feb 7.
PMID: 23392654, PMCID: PMC3715320

Pharmacogenetics, enzyme probes and therapeutic drug monitoring as potential tools for individualizing taxane therapy.
Krens SD, McLeod HL, Hertz DL.
Pharmacogenomics. 2013 Apr;14(5):555-74. doi: 10.2217/pgs.13.33.
PMID: 23556452, PMCID: PMC3975654

Alternative splicing in the regulation of cholesterol homeostasis.
Medina MW, Krauss RM.
Curr Opin Lipidol. 2013 Apr;24(2):147-52. doi: 10.1097/MOL.0b013e32835cf284. Review.
PMID: 23314925, PMCID: PMC3667406

Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics.
McDonough CW, Burbage SE, Duarte JD, Gong Y, Langaee TY, Turner ST, Gums JG, Chapman AB, Bailey KR, Beitelshees AL, Boerwinkle E, Pepine CJ, Cooper-DeHoff RM, Johnson JA.
J Hypertens. 2013 Apr;31(4):698-704. doi: 10.1097/HJH.0b013e32835e2a71.
PMID: 23353631, PMCID: PMC3756535

Two-phase designs to follow-up genome-wide association signals with DNA resequencing studies.
Schaid DJ, Jenkins GD, Ingle JN, Weinshilboum RM.
Genet Epidemiol. 2013 Apr;37(3):229-38. doi: 10.1002/gepi.21708. Epub 2013 Jan 24.
PMID: 23348637, PMCID: PMC3740575

Valproic acid pathway: pharmacokinetics and pharmacodynamics.
Ghodke-Puranik Y, Thorn CF, Lamba JK, Leeder JS, Song W, Birnbaum AK, Altman RB, Klein TE.
Pharmacogenet Genomics. 2013 Apr;23(4):236-41. doi: 10.1097/FPC.0b013e32835ea0b2. No abstract available.
PMID: 23407051, PMCID: PMC3696515

Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3.
Chen L, Hong C, Chen EC, Yee SW, Xu L, Almof EU, Wen C, Fujii K, Johns SJ, Stryke D, Ferrin TE, Simko J, Chen X, Costello JF, Giacomini KM.
Pharmacogenomics J. 2013 Apr;13(2):110-20. doi: 10.1038/tpj.2011.60. Epub 2012 Jan 10.
PMID: 22231567, PMCID: PMC3396779

CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers.
Chenoweth MJ, O'Loughlin J, Sylvestre MP, Tyndale RF.
Pharmacogenet Genomics. 2013 Apr;23(4):232-5. doi: 10.1097/FPC.0b013e32835f834d.
PMID: 23462429, PMCID: PMC3744214

Nomenclature for alleles of the thiopurine methyltransferase gene.
Appell ML, Berg J, Duley J, Evans WE, Kennedy MA, Lennard L, Marinaki T, McLeod HL, Relling MV, Schaeffeler E, Schwab M, Weinshilboum R, Yeoh AE, McDonagh EM, Hebert JM, Klein TE, Coulthard SA.
Pharmacogenet Genomics. 2013 Apr;23(4):242-8. doi: 10.1097/FPC.0b013e32835f1cc0.
PMID: 23407052, PMCID: PMC3727893

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL, Kwok PY, Gilliland FD, Gauderman WJ, Bleecker ER, Raby BA, Meyers DA, London SJ, Martinez FD, Weiss ST, Burchard EG, Nicolae DL, Ober C, Barnes KC, Williams LK.
J Allergy Clin Immunol. 2013 Apr;131(4):1176-84. doi: 10.1016/j.jaci.2012.10.002. Epub 2012 Nov 10.
PMID: 23146381, PMCID: PMC3596497

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1.
Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM.
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5480-5. doi: 10.1073/pnas.1218165110. Epub 2013 Mar 18.
PMID: 23509259, PMCID: PMC3619328

Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers.
Esterlis I, Hannestad JO, Perkins E, Bois F, D'Souza DC, Tyndale RF, Seibyl JP, Hatsukami DM, Cosgrove KP, O'Malley SS.
Am J Psychiatry. 2013 Apr 1;170(4):399-407. doi: 10.1176/appi.ajp.2012.12060793.
PMID: 23429725, PMCID: PMC3738000

Emerging Transporters of Clinical Importance: An Update from the International Transporter Consortium.
Hillgren KM, Keppler D, Zur A, Giacomini KM, Stieger B, Cass CE, Zhang L.
Clin Pharmacol Ther. 2013 Apr 8. doi: 10.1038/clpt.2013.74. 
PMID: 23588305,

All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs.
Schork AJ, Thompson WK, Pham P, Torkamani A, Roddey JC, Sullivan PF, Kelsoe JR, O'Donovan MC, Furberg H; Tobacco and Genetics Consortium; Bipolar Disorder Psychiatric Genomics Consortium; Schizophrenia Psychiatric Genomics Consortium, Schork NJ, Andreassen OA, Dale AM.
PLoS Genet. 2013 Apr;9(4):e1003449. doi: 10.1371/journal.pgen.1003449. Epub 2013 Apr 25.
PMID: 23637621, PMCID: PMC3636284

Amlodipine--not a significant contributor to clopidogrel non-response?
Kreutz RP, Flockhart DA.
Heart. 2013 Apr;99(7):437-9. doi: 10.1136/heartjnl-2012-303214.
PMID: 23315611, PMCID: PMC4064296

 

February 2013Back to top

An integrated pharmacokinetics ontology and corpus for text mining.
Wu HY, Karnik S, Subhadarshini A, Wang Z, Philips S, Han X, Chiang C, Liu L, Boustani M, Rocha LM, Quinney SK, Flockhart D, Li L.
BMC Bioinformatics. 2013 Feb 1;14:35. doi: 10.1186/1471-2105-14-35.
PMID: 23374886

A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.
Lee HJ, Woo HG, Greenwood TA, Kripke DF, Kelsoe JR.
J Affect Disord. 2013 Feb 20;145(2):200-7. doi: 10.1016/j.jad.2012.07.032. Epub 2012 Aug 25.
PMID: 22925353

Preventing adverse drug-drug interactions: a need for improved data and logistics.
Seminerio MJ, Ratain MJ.
Mayo Clin Proc. 2013 Feb;88(2):126-8. doi: 10.1016/j.mayocp.2012.12.005. No abstract available.
PMID: 23374616

An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
Yang T, Smith JA, Leake BF, Sanders CR, Meiler J, Roden DM.
Mol Pharmacol. 2013 Feb;83(2):481-9. doi: 10.1124/mol.112.081513. Epub 2012 Nov 28.
PMID: 23193163

Genome-wide study of methotrexate clearance replicates SLCO1B1.
Ramsey LB, Panetta JC, Smith C, Yang W, Fan Y, Winick NJ, Martin PL, Cheng C, Devidas M, Pui CH, Evans WE, Hunger SP, Loh M, Relling MV.
Blood. 2013 Feb 7;121(6):898-904. doi: 10.1182/blood-2012-08-452839. 
PMID: 23233662

The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish.
Horenstein RB, Mitchell BD, Post WS, Lütjohann D, von Bergmann K, Ryan KA, Terrin M, Shuldiner AR, Steinle NI.
Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):413-9. doi: 10.1161/ATVBAHA.112.245480.
PMID: 23241408

Correction: RHOA Is a Modulator of the Cholesterol-Lowering Effects of Statin.
Medina MW, Theusch E, Naidoo D, Bauzon F, Stevens K, Mangravite LM, Kuang YL, Krauss RM.
PLoS Genet. 2013 Feb;9(2).
PMID: 23447741

The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.
Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM.
Clin Pharmacol Ther. 2013 Feb;93(2):186-94.
PMID: 23267855

Enabling Genomic-Phenomic Association Discovery without Sacrificing Anonymity.
Heatherly RD, Loukides G, Denny JC, Haines JL, Roden DM, Malin BA.
PLoS One. 2013;8(2):e53875. doi: 10.1371/journal.pone.0053875. Epub 2013 Feb 6.
PMID: 23405076

Informatics confronts drug-drug interactions.
Percha B, Altman RB.
Trends Pharmacol Sci. 2013 Feb 12. doi:pii: S0165-6147(13)00007-2. 10.1016/j.tips.2013.01.006.
PMID: 23414686

Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel.
Gurbel PA, Bliden KP, Fort JG, Jeong YH, Shuldiner A, Chai S, Gesheff T, Antonino M, Gesheff M, Zhang Y, Tantry US.
Am Heart J. 2013 Feb;165(2):176-82. doi: 10.1016/j.ahj.2012.07.032. 
PMID: 23351820

Interview: Richard M Weinshilboum talks to Hannah Branch, Assistant Commissioning Editor.
Weinshilboum RM.
Biomark Med. 2013 Feb;7(1):5-10. doi: 10.2217/bmm.12.106. No abstract available.
PMID: 23387480

Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, Kassem L, Park JH, Chatterjee N, Jamain S, Cheng A, Leboyer M, Muglia P, Schulze TG, Cichon S, Nöthen MM, Rietschel M; BiGS, McMahon FJ, Kelsoe JR, Greenwood TA, Nievergelt CM, McKinney R, Shilling PD, Schork NJ, Smith EN, Bloss CS, Nurnberger JI Jr, Edenberg HJ, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon FJ, Chen DT, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Schulze TG.
Mol Psychiatry. 2013 Feb;18(2):195-205. doi: 10.1038/mp.2011.157. Epub 2011 Dec 20.
PMID: 22182935

January 2013Back to top

Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: exploration of a novel CYP2B6 phenotyping index.
Jiang F, Desta Z, Shon JH, Yeo CW, Kim HS, Liu KH, Bae SK, Lee SS, Flockhart DA, Shin JG.
Br J Clin Pharmacol. 2013 Jan;75(1):244-53. doi: 10.1111/j.1365-2125.2012.04314.x. Erratum in: Br J Clin Pharmacol. 2013 Apr;75(4):1171.
PMID: 22554354

Pharmacogenomics as a risk mitigation strategy for chemotherapeutic cardiotoxicity.
Jensen BC, McLeod HL.
Pharmacogenomics. 2013 Jan;14(2):205-13. doi: 10.2217/pgs.12.205. Review.
PMID: 23327580

Drug-induced arrhythmia: pharmacogenomic prescribing?
Behr ER, Roden D.
Eur Heart J. 2013 Jan;34(2):89-95. doi: 10.1093/eurheartj/ehs351. Epub 2012 Oct 22. Review.
PMID: 23091201

The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
Lewis JP, Horenstein RB, Ryan K, O'Connell JR, Gibson Q, Mitchell BD, Tanner K, Chai S, Bliden KP, Tantry US, Peer CJ, Figg WD, Spencer SD, Pacanowski MA, Gurbel PA, Shuldiner AR.
Pharmacogenet Genomics. 2013 Jan;23(1):1-8. doi: 10.1097/FPC.0b013e32835aa8a2.
PMID: 23111421

The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).
Lewis LD, Miller AA, Owzar K, Bies RR, Markova S, Jiang C, Kroetz DL, Egorin MJ, McLeod HL, Ratain MJ; Alliance for Clinical Trials in Oncology.
Pharmacogenet Genomics. 2013 Jan;23(1):29-33. doi: 10.1097/FPC.0b013e32835b16d8.
PMID: 23188068

Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.
Zhu AZ, Binnington MJ, Renner CC, Lanier AP, Hatsukami DK, Stepanov I, Watson CH, Sosnoff CS, Benowitz NL, Tyndale RF.
Carcinogenesis. 2013 Jan;34(1):93-101.
PMID: 23027621

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update.
Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Hicks JK, Schwab M, Klein TE.
Clin Pharmacol Ther. 2013 Jan 17. doi: 10.1038/clpt.2013.4. 
PMID: 23422873

Cardiovascular pharmacogenomics: the future of cardiovascular therapeutics?
Roden DM.
Can J Cardiol. 2013 Jan;29(1):58-66. doi: 10.1016/j.cjca.2012.07.845. 
PMID: 23200096

Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.
Poulton EJ, Levy L, Lampe JW, Shen DD, Tracy J, Shuhart MC, Thummel KE, Eaton DL.
Toxicol Appl Pharmacol. 2013 Jan 1;266(1):122-31. doi: 10.1016/j.taap.2012.10.029.
PMID: 23153560

Personal genomic measurements: the opportunity for information integration.
Altman RB.
Clin Pharmacol Ther. 2013 Jan;93(1):21-3. doi: 10.1038/clpt.2012.203. Review.
PMID: 23241835

Cancer pharmacogenomics: strategies and challenges.
Wheeler HE, Maitland ML, Dolan ME, Cox NJ, Ratain MJ.
Nat Rev Genet. 2013 Jan;14(1):23-34. doi: 10.1038/nrg3352. Epub 2012 Nov 27. Review.
PMID: 23183705

CYP3A5 Gene Variation Influences Cyclosporine A Metabolite Formation and Renal Cyclosporine Disposition.
Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD, Thummel KE.
Transplantation. 2013 Jan 24. 
PMID: 23354298

Incidental genetic findings in randomized clinical trials: recommendations from the Genomics and Randomized Trials Network (GARNET).
Bookman EB, Din-Lovinescu C, Worrall BB, Manolio TA, Bennett SN, Laurie C, Mirel DB, Doheny KF, Anderson GL, Wehr K, Weinshilboum R, Chen DT; for GARNET.
Genome Med. 2013 Jan 30;5(1):7. 
PMID: 23363732

The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race and sex.
Zhu AZ, Renner C, Hatsukami DK, Swan G, Lerman CE, Benowitz NL, Tyndale RF.
Cancer Epidemiol Biomarkers Prev. 2013 Jan 31.
PMID: 23371292

Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction.
Sullivan D, Pinsonneault JK, Papp AC, Zhu H, Lemeshow S, Mash DC, Sadee W.
Transl Psychiatry. 2013 Jan 22;3:e222. doi: 10.1038/tp.2012.146.
PMID: 23340505

Two-Phase Designs to Follow-Up Genome-Wide Association Signals With DNA Resequencing Studies.
Schaid DJ, Jenkins GD, Ingle JN, Weinshilboum RM.
Genet Epidemiol. 2013 Jan 24. doi: 10.1002/gepi.21708.
PMID: 23348637

FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder.
Ellsworth KA, Moon I, Eckloff BW, Fridley BL, Jenkins GD, Batzler A, Biernacka JM, Abo R, Brisbin A, Ji Y, Hebbring S, Wieben ED, Mrazek DA, Weinshilboum RM, Wang L.
Pharmacogenet Genomics. 2013 Jan 15. 
PMID: 23324805

Implementing genomic medicine in the clinic: the future is here.
Manolio TA, Chisholm RL, Ozenberger B, Roden DM, Williams MS, Wilson R, Bick D, Bottinger EP, Brilliant MH, Eng C, Frazer KA, Korf B, Ledbetter DH, Lupski JR, Marsh C, Mrazek D, Murray MF, O'Donnell PH, Rader DJ, Relling MV, Shuldiner AR, Valle D, Weinshilboum R, Green ED, Ginsburg GS.
Genet Med. 2013 Jan 10. doi: 10.1038/gim.2012.157.
PMID: 23306799

Publications from 2012 

December 2012Back to top

Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study.
Gong Y, McDonough CW, Wang Z, Hou W, Cooper-DeHoff RM, Langaee TY, Beitelshees AL, Chapman AB, Gums JG, Bailey KR, Boerwinkle E, Turner ST, Johnson JA.
Circ Cardiovasc Genet. 2012 Dec;5(6):686-91. doi: 10.1161/CIRCGENETICS.112.964080. Epub 2012 Oct 19.
PMID: 23087401

Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.
Holzinger ER, Grady B, Ritchie MD, Ribaudo HJ, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford DB, Daar ES, McLaren P, Haas DW.
Pharmacogenet Genomics. 2012 Dec;22(12):858-67. doi: 10.1097/FPC.0b013e32835a450b.
PMID: 23080225

PharmGKB summary: zidovudine pathway.
Ghodke Y, Anderson PL, Sangkuhl K, Lamba J, Altman RB, Klein TE.
Pharmacogenet Genomics. 2012 Dec;22(12):891-4. doi: 10.1097/FPC.0b013e32835879a8. No abstract available.
PMID: 22960662

Gender-stratified gene and gene-treatment interactions in smoking cessation.
Lee W, Bergen AW, Swan GE, Li D, Liu J, Thomas P, Tyndale RF, Benowitz NL, Lerman C, Conti DV.
Pharmacogenomics J. 2012 Dec;12(6):521-32. doi: 10.1038/tpj.2011.30. Epub 2011 Aug 2.
PMID: 21808284

Identifying the genetic variation of gene expression using gene sets: application of novel gene Set eQTL approach to PharmGKB and KEGG.
Abo R, Jenkins GD, Wang L, Fridley BL.
PLoS One. 2012;7(8):e43301. doi: 10.1371/journal.pone.0043301.
PMID: 22905253

Tamoxifen and CYP2D6: a contradiction of data.
Hertz DL, McLeod HL, Irvin WJ Jr.
Oncologist. 2012;17(5):620-30. doi: 10.1634/theoncologist.2011-0418.
PMID: 22531359

CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion.
Zhu AZ, Cox LS, Nollen N, Faseru B, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF.
Clin Pharmacol Ther. 2012 Dec;92(6):771-7. doi: 10.1038/clpt.2012.186. 
PMID: 23149928

Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis.
Danese E, Montagnana M, Johnson JA, Rettie AE, Zambon CF, Lubitz SA, Suarez-Kurtz G, Cavallari LH, Zhao L, Huang M, Nakamura Y, Mushiroda T, Kringen MK, Borgiani P, Ciccacci C, Au NT, Langaee T, Siguret V, Loriot MA, Sagreiya H, Altman RB, Shahin MH, Scott SA, Khalifa SI, Chowbay B, Suriapranata IM, Teichert M, Stricker BH, Taljaard M, Botton MR, Zhang JE, Pirmohamed M, Zhang X, Carlquist JF, Horne BD, Lee MT, Pengo V, Guidi GC, Minuz P, Fava C.
Clin Pharmacol Ther. 2012 Dec;92(6):746-56. doi: 10.1038/clpt.2012.184. 
PMID: 23132553

Chapter 7: pharmacogenomics.
Karczewski KJ, Daneshjou R, Altman RB.
PLoS Comput Biol. 2012 Dec;8(12):e1002817. doi: 10.1371/journal.pcbi.1002817. Epub 2012 Dec 27.
PMID: 23300409

Is (+)-[(13)C]-pantoprazole better than (±)-[(13)C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity?
Thacker DL, Modak A, Flockhart DA, Desta Z.
J Breath Res. 2012 Dec 21;7(1):016001. 
PMID: 23257668

Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.
Bergen AW, Javitz HS, Krasnow R, Nishita D, Michel M, Conti DV, Liu J, Lee W, Edlund CK, Hall S, Kwok PY, Benowitz NL, Baker TB, Tyndale RF, Lerman C, Swan GE.
Pharmacogenet Genomics. 2012 Dec 14. 
PMID: 23249876

Multivariate methods and software for association mapping in dose-response genome-wide association studies.
Brown CC, Havener TM, Medina MW, Krauss RM, McLeod HL, Motsinger-Reif AA.
BioData Min. 2012 Dec 12;5(1):21. 
PMID: 23234571

CYP2D6 Metabolism and Patient Outcome in the Austrian Breast and Colorectal Cancer Study Group Trial (ABCSG) 8.
Goetz MP, Suman V, Hoskin TL, Gnant M, Filipits M, Safgren S, Kuffel MJ, Jakesz R, Rudas M, Greil R, Dietze O, Lang A, Offner F, Reynolds CA, Weinshilboum RM, Ames M, Ingle JN.
Clin Cancer Res. 2012 Dec 4.
PMID: 23213055

The DRD4 Exon III VNTR, Bupropion, and Associations With Prospective Abstinence.
Bergen AW, Javitz HS, Su L, He Y, Conti DV, Benowitz NL, Tyndale RF, Lerman C, Swan GE.
Nicotine Tob Res. 2012 Dec 3. 
PMID: 23212438

Cotinine in Human Placenta Predicts Induction of Gene Expression in Fetal Tissues.
Vyhlidal CA, Riffel AK, Haley KJ, Sharma S, Dai H, Tantisira KG, Weiss ST, Leeder JS.
Drug Metab Dispos. 2012 Dec 3. 
PMID: 23209192

Cytochrome P450-mediated drug metabolism in the brain.
Miksys S, Tyndale RF.
J Psychiatry Neurosci. 2012 Dec 4;37(6):120133. doi: 10.1503/jpn.120133. 
PMID: 23199531

November 2012Back to top

Pharmacogenetics and healthcare outcomes in patients with chronic heart failure.
Kim KM, Murray MD, Tu W, Robarge J, Ding Y, Brater DC, Flockhart DA.
Eur J Clin Pharmacol. 2012 Nov;68(11):1483-91. doi: 10.1007/s00228-012-1280-z.
PMID: 22543981

High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.
Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini KM, Sali A.
J Biol Chem. 2012 Nov 2;287(45):37745-56. doi: 10.1074/jbc.M112.388157. .
PMID: 22932902

Inclusion of Pediatric Samples in an Opt-Out Biorepository Linking DNA to De-Identified Medical Records: Pediatric BioVU.
McGregor TL, Van Driest SL, Brothers KB, Bowton EA, Muglia LJ, Roden DM.
Clin Pharmacol Ther. 2012 Nov 21. doi: 10.1038/clpt.2012.230.
PMID: 23281421

Next-generation sequencing in the clinic: are we ready?
Biesecker LG, Burke W, Kohane I, Plon SE, Zimmern R.
Nat Rev Genet. 2012 Nov;13(11):818-24. doi: 10.1038/nrg3357.
PMID: 23076269

A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record.
Hicks JK, Crews KR, Hoffman JM, Kornegay NM, Wilkinson MR, Lorier R, Stoddard A, Yang W, Smith C, Fernandez CA, Cross SJ, Haidar C, Baker DK, Howard SC, Evans WE, Broeckel U, Relling MV.
Clin Pharmacol Ther. 2012 Nov;92(5):563-6. doi: 10.1038/clpt.2012.140.
PMID: 22990750

Response to "Doubt About the Feasibility of Preemptive Genotyping"
Denny JC, Schildcrout JS, Pulley JM, Roden DM.
Clin Pharmacol Ther. 2012 Nov 7. doi: 10.1038/clpt.2012.223. 
PMID: 23249779

Predictors of cessation in African American light smokers enrolled in a bupropion clinical trial.
Faseru B, Nollen NL, Mayo MS, Krebill R, Choi WS, Benowitz NL, Tyndale RF, Okuyemi KS, Ahluwalia JS, Sanderson Cox L.
Addict Behav. 2012 Nov 29;38(3):1796-1803. doi: 10.1016/j.addbeh.2012.11.010. 
PMID: 23254230

Making pharmacogenetic testing a reality in a community pharmacy.
O'Connor SK, Ferreri SP, Michaels NM, Chater RW, Viera AJ, Faruki H, McLeod HL, Roederer M.
J Am Pharm Assoc (2003). 2012 Nov 1;52(6):e259-65. doi: 10.1331/JAPhA.2012.12108.
PMID: 23229988

Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm.
Müller II, Melville DB, Tanwar V, Rybski WM, Mukherjee A, Shoemaker BM, Wang WD, Schoenhard JA, Roden DM, Darbar D, Knapik EW, Hatzopoulos AK.
Dis Model Mech. 2012 Dec 7.
PMID: 23223679

Developing a Prototype System for Integrating Pharmacogenomics Findings into Clinical Practice.
Overby CL, Tarczy-Hornoch P, Kalet IJ, Thummel KE, Smith JW, Fiol GD, Fenstermacher D, Devine EB.
J Pers Med. 2012 Nov 20;2(4):241-256.
PMID: 23741623

PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.
Stocco G, Yang W, Crews KR, Thierfelder WE, Decorti G, Londero M, Franca R, Rabusin M, Valsecchi MG, Pei D, Cheng C, Paugh SW, Ramsey LB, Diouf B, McCorkle JR, Jones TS, Pui CH, Relling MV, Evans WE.
Hum Mol Genet. 2012 Nov 1;21(21):4793-804. doi: 10.1093/hmg/dds302. 
PMID: 22846425

Metformin pathways: pharmacokinetics and pharmacodynamics.
Gong L, Goswami S, Giacomini KM, Altman RB, Klein TE.
Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22. 
PMID: 22722338

A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.
Brown CC, Havener TM, Medina MW, Auman JT, Mangravite LM, Krauss RM, McLeod HL, Motsinger-Reif AA.
Pharmacogenet Genomics. 2012 Nov;22(11):796-802. doi: 10.1097/FPC.0b013e3283589c50.
PMID: 23047291

Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of paclitaxel-induced sensory peripheral neuropathy.
Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, Baldwin RM, Owzar K, Jiang C, Watson D, Shterev I, Kubo M, Zembutsu H, Winer EP, Hudis CA, Shulman L, Nakamura Y, Ratain MJ, Kroetz D, Cox NJ, Dolan ME.
Clin Cancer Res. 2012 Nov 30.
PMID: 23204130

Common Atrial Fibrillation Risk Alleles at 4q25 Predict Recurrence after Catheter-based Atrial Fibrillation Ablation.
Benjamin Shoemaker M, Muhammad R, Parvez B, White BW, Streur M, Song Y, Stubblefield T, Kucera G, Blair M, Rytlewski J, Parvathaneni S, Nagarakanti R, Saavedra P, Ellis C, Patrick Whalen S, Roden DM, Darbar D.
Heart Rhythm. 2012 Nov 22. doi:pii: S1547-5271(12)01340-9. 10.1016/j.hrthm.2012.11.012.
PMID: 23178686

Informed conditioning on clinical covariates increases power in case-control association studies.
Zaitlen N, Lindström S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeböller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, Landi MT, Langefeld CD, Le Marchand L, Meister M, Morgan AW, Raji OY, Risch A, Rosenberger A, Scherf D, Steer S, Walshaw M, Waters KM, Wilson AG, Wordsworth P, Zienolddiny S, Tchetgen ET, Haiman C, Hunter DJ, Plenge RM, Worthington J, Christiani DC, Schaumberg DA, Chasman DI, Altshuler D, Voight B, Kraft P, Patterson N, Price AL.
PLoS Genet. 2012 Nov;8(11):e1003032. doi: 10.1371/journal.pgen.1003032.
PMID: 23144628

Renal Transporters in Drug Development.
Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM.
Annu Rev Pharmacol Toxicol. 2012 Nov 8.
PMID: 23140242

Dietary restrictions and drug interactions with monoamine oxidase inhibitors: an update.
Flockhart DA.
J Clin Psychiatry. 2012;73 Suppl 1:17-24. doi: 10.4088/JCP.11096su1c.03. Review.
PMID: 22951238

 

October 2012Back to top

Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation.
Ji Y, Nordgren KK, Chai Y, Hebbring SJ, Jenkins GD, Abo RP, Peng Y, Pelleymounter LL, Moon I, Eckloff BW, Chai X, Zhang J, Fridley BL, Yee VC, Wieben ED, Weinshilboum RM.
Drug Metab Dispos. 2012 Oct;40(10):1984-92. doi: 10.1124/dmd.112.046953. 
PMID: 22807109

Very important pharmacogene summary for VDR.
Poon AH, Gong L, Brasch-Andersen C, Litonjua AA, Raby BA, Hamid Q, Laprise C, Weiss ST, Altman RB, Klein TE.
Pharmacogenet Genomics. 2012 Oct;22(10):758-63. Review. No abstract available.
PMID: 22588316

Pharmacogenomics knowledge for personalized medicine.
Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE.
Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. Review.
PMID: 22992668

Ready when you are: easing into preemptive pharmacogenetics.
He YJ, McLeod HL.
Clin Pharmacol Ther. 2012 Oct;92(4):412-4. doi: 10.1038/clpt.2012.144. Review.
PMID: 22992667

G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.
Vandell AG, Lobmeyer MT, Gawronski BE, Langaee TY, Gong Y, Gums JG, Beitelshees AL, Turner ST, Chapman AB, Cooper-DeHoff RM, Bailey KR, Boerwinkle E, Pepine CJ, Liggett SB, Johnson JA.
Hypertension. 2012 Oct;60(4):957-64. doi: 10.1161/HYPERTENSIONAHA.112.198721.
PMID: 22949529

Pharmacogenomics and individualized medicine: translating science into practice.
Crews KR, Hicks JK, Pui CH, Relling MV, Evans WE.
Clin Pharmacol Ther. 2012 Oct;92(4):467-75. doi: 10.1038/clpt.2012.120.
PMID: 22948889

The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics.
O'Donnell PH, Bush A, Spitz J, Danahey K, Saner D, Das S, Cox NJ, Ratain MJ.
Clin Pharmacol Ther. 2012 Oct;92(4):446-9. doi: 10.1038/clpt.2012.117.
PMID: 22929923

Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array.
Johnson JA, Burkley BM, Langaee TY, Clare-Salzler MJ, Klein TE, Altman RB.
Clin Pharmacol Ther. 2012 Oct;92(4):437-9. doi: 10.1038/clpt.2012.125.
PMID: 22910441

The relevance of "missing heritability " in pharmacogenomics.
Sadee W.
Clin Pharmacol Ther. 2012 Oct;92(4):428-30. doi: 10.1038/clpt.2012.116.
PMID: 22910439

Strategies for personalized medicine-based research and implementation in the clinical workflow.
Lieb W, Völzke H, Pulley JM, Roden DM, Kroemer HK.
Clin Pharmacol Ther. 2012 Oct;92(4):443-5. doi: 10.1038/clpt.2012.119. 
PMID: 22910438

Measurement and Compartmental Modeling of the Effect of CYP3A5 Gene Variation on Systemic and Intrarenal Tacrolimus Disposition.
Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD, Thummel KE.
Clin Pharmacol Ther. 2012 Oct 17. doi: 10.1038/clpt.2012.175.
PMID: 23073208

Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.
Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK.
Int J Mol Imaging. 2012;2012:250834. doi: 10.1155/2012/250834. 
PMID: 23050139

Primary care physicians' knowledge of and experience with pharmacogenetic testing.
Haga SB, Burke W, Ginsburg GS, Mills R, Agans R.
Clin Genet. 2012 Oct;82(4):388-94. doi: 10.1111/j.1399-0004.2012.01908.x.
PMID: 22698141

 

September 2012Back to top

Mice lacking the β2 adrenergic receptor have a unique genetic profile before and after focal brain ischaemia.
White RE, Palm C, Xu L, Ling E, Ginsburg M, Daigle BJ, Han R, Patterson A, Altman RB, Giffard RG.
ASN Neuro. 2012 Sep 7;4(5). pii: e00096. doi: 10.1042/AN20110020.
PMID: 22867428, PMCID: PMC3436074

Pharmacogenomics and patient care: one size does not fit all.
Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y.
Sci Transl Med. 2012 Sep 26;4(153):153ps18. Review.
PMID: 23019654

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
Niu N, Schaid DJ, Abo RP, Kalari K, Fridley BL, Feng Q, Jenkins G, Batzler A, Brisbin AG, Cunningham JM, Li L, Sun Z, Yang P, Wang L.
BMC Cancer. 2012 Sep 24;12:422. doi: 10.1186/1471-2407-12-422.
PMID: 23006423

PharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6.
McDonagh EM, Wassenaar C, David SP, Tyndale RF, Altman RB, Whirl-Carrillo M, Klein TE.
Pharmacogenet Genomics. 2012 Sep;22(9):695-708. doi: 10.1097/FPC.0b013e3283540217. Review. 
PMID: 23539596

A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.
Baldwin RM, Owzar K, Zembutsu H, Chhibber A, Kubo M, Jiang C, Watson D, Eclov RJ, Mefford J, McLeod HL, Friedman PN, Hudis CA, Winer EP, Jorgenson EM, Witte JS, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL.
Clin Cancer Res. 2012 Sep 15;18(18):5099-109.
PMID: 22843789

Safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8055 in advanced solid tumours and lymphoma.
Naing A, Aghajanian C, Raymond E, Olmos D, Schwartz G, Oelmann E, Grinsted L, Burke W, Taylor R, Kaye S, Kurzrock R, Banerji U.
Br J Cancer. 2012 Sep 25;107(7):1093-9. doi: 10.1038/bjc.2012.368.
PMID: 22935583

The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.
Florez JC, Jablonski KA, Taylor A, Mather K, Horton E, White NH, Barrett-Connor E, Knowler WC, Shuldiner AR, Pollin TI; Diabetes Prevention Program Research Group.
Diabetes Care. 2012 Sep;35(9):1864-7. 
PMID: 22751958

The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.
Mann A, Miksys SL, Gaedigk A, Kish SJ, Mash DC, Tyndale RF.
Neurobiol Aging. 2012 Sep;33(9):2160-71. doi: 10.1016/j.neurobiolaging.2011.08.014.
PMID: 21958961

Concordance of DMET plus genotyping results with those of orthogonal genotyping methods.
Fernandez CA, Smith C, Yang W, Lorier R, Crews KR, Kornegay N, Hicks JK, Stewart CF, Kawedia JD, Ramsey LB, Liu C, Evans WE, Relling MV, Broeckel U.
Clin Pharmacol Ther. 2012 Sep;92(3):360-5. doi: 10.1038/clpt.2012.95.
PMID: 22871999

Genome-wide association analysis of circulating vitamin D levels in children with asthma.
Lasky-Su J, Lange N, Brehm JM, Damask A, Soto-Quiros M, Avila L, Celedón JC, Canino G, Cloutier MM, Hollis BW, Weiss ST, Litonjua AA.
Hum Genet. 2012 Sep;131(9):1495-505. doi: 10.1007/s00439-012-1185-z. 
PMID: 22673963

Genetic contribution to variable human CYP3A-mediated metabolism.
Lamba JK, Lin YS, Schuetz EG, Thummel KE.
Adv Drug Deliv Rev. 2012 Sep 13. pii: S0169-409X(12)00277-3. doi: 10.1016/j.addr.2012.09.017.
PMID: 22983347

 

August 2012Back to top

PharmGKB summary: very important pharmacogene information for GSTT1.
Thorn CF, Ji Y, Weinshilboum RM, Altman RB, Klein TE.
Pharmacogenet Genomics. 2012 Aug;22(8):646-51. doi: 10.1097/FPC.0b013e3283527c02. 
PMID: 22643671

Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.
Pollin TI, Isakova T, Jablonski KA, de Bakker PI, Taylor A, McAteer J, Pan Q, Horton ES, Delahanty LM, Altshuler D, Shuldiner AR, Goldberg RB, Florez JC, Franks PW; Diabetes Prevention Program Research Group.
PLoS Genet. 2012;8(8):e1002895. Epub 2012 Aug 30.
PMID: 22951888

Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependent on clopidogrel response.
Kreutz RP, Breall JA, Kreutz Y, Owens J, Lu D, Bolad I, von der Lohe E, Sinha A, Flockhart DA.
Thromb Res. 2012 Aug;130(2):198-202. doi: 10.1016/j.thromres.2012.02.049.
PMID: 22459907

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.
Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, Camm AJ, Jeffery S, Roden DM, Behr ER.
J Am Coll Cardiol. 2012 Aug 28;60(9):841-50. doi: 10.1016/j.jacc.2012.03.031.
PMID: 22682551

Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping.
Schildcrout JS, Denny JC, Bowton E, Gregg W, Pulley JM, Basford MA, Cowan JD, Xu H, Ramirez AH, Crawford DC, Ritchie MD, Peterson JF, Masys DR, Wilke RA, Roden DM.
Clin Pharmacol Ther. 2012 Aug;92(2):235-42. doi: 10.1038/clpt.2012.66.
PMID: 22739144

Differential Effects of Nicotine Treatment and Ethanol Self-administration on CYP2A6, CYP2B6 and Nicotine Pharmacokinetics in African Green Monkeys.
Ferguson CS, Miksys S, Palmour RM, Tyndale RF.
J Pharmacol Exp Ther. 2012 Aug 30.
PMID: 22935730

Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions.
Duke JD, Han X, Wang Z, Subhadarshini A, Karnik SD, Li X, Hall SD, Jin Y, Callaghan JT, Overhage MJ, Flockhart DA, Strother RM, Quinney SK, Li L.
PLoS Comput Biol. 2012 Aug;8(8):e1002614.
PMID: 22912565

Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment.
Karnes JH, McDonough CW, Gong Y, Vo TT, Langaee TY, Chapman AB, Gums JG, Beitelshees AL, Bailey KR, Del-Aguila JL, Boerwinkle EA, Pepine CJ, Turner ST, Johnson JA, Cooper-Dehoff RM.
Pharmacogenomics J. 2012 Aug 21. doi: 10.1038/tpj.2012.34. 
PMID: 22907731

Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics.
Ji Y, Biernacka JM, Hebbring S, Chai Y, Jenkins GD, Batzler A, Snyder KA, Drews MS, Desta Z, Flockhart D, Mushiroda T, Kubo M, Nakamura Y, Kamatani N, Schaid D, Weinshilboum RM, Mrazek DA.
Pharmacogenomics J. 2012 Aug 21. doi: 10.1038/tpj.2012.32.
PMID: 22907730

The state of the art in text mining and natural language processing for pharmacogenomics.
Coulet A, Cohen KB, Altman RB.
J Biomed Inform. 2012 Aug 9.
PMID: 22885340

July 2012Back to top

Informed Consent in Genome-Scale Research: What Do Prospective Participants Think?
Trinidad SB, Fullerton SM, Bares JM, Jarvik GP, Larson EB, Burke W.
AJOB Prim Res. 2012 Jul 1;3(3):3-11.
PMID: 23493836

The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition.
Michaud V, Bar-Magen T, Turgeon J, Flockhart D, Desta Z, Wainberg MA.
Pharmacol Rev. 2012 Jul;64(3):803-33. doi: 10.1124/pr.111.005553. Review.
PMID: 22759796

Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.
Himes BE, Jiang X, Hu R, Wu AC, Lasky-Su JA, Klanderman BJ, Ziniti J, Senter-Sylvia J, Lima JJ, Irvin CG, Peters SP, Meyers DA, Bleecker ER, Kubo M, Tamari M, Nakamura Y, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD, Hanrahan JP, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Panettieri RA Jr, Markezich A, Israel E, Carey VJ, Tantisira KG, Litonjua AA, Lu Q, Weiss ST.
PLoS Genet. 2012 Jul;8(7):e1002824. 
PMID: 22792082

Bioinformatics and variability in drug response: a protein structural perspective.
Lahti JL, Tang GW, Capriotti E, Liu T, Altman RB.
J R Soc Interface. 2012 Jul 7;9(72):1409-37. 
PMID: 22552919

Re: CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women With Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial.
Nakamura Y, Ratain MJ, Cox NJ, McLeod HL, Kroetz DL, Flockhart DA.
J Natl Cancer Inst. 2012 Jul 31.
PMID: 22851270

Dedication to Professor Leslie Z. Benet: 50 Years of Scientific Excellence and Still Going Strong!
Smith DE, Rowland M, Giacomini KM, Amidon GL.
Pharm Res. 2012 Jul 20.
PMID: 22814901

Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment.
Trupp M, Zhu H, Wikoff WR, Baillie RA, Zeng ZB, Karp PD, Fiehn O, Krauss RM, Kaddurah-Daouk R.
PLoS One. 2012;7(7):e38386. Epub 2012 Jul 9.
PMID: 22808006

Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation.
Thirumaran RK, Lamba JK, Kim RB, Urquhart BL, Gregor JC, Chande N, Fan Y, Qi A, Cheng C, Thummel KE, Hall SD, Schuetz EG.
Biochem Pharmacol. 2012 Jul 1;84(1):104-12.
PMID: 22484315

Principles of pharmacogenetics and pharmacogenomics.
Kelsoe JR.
Clin Pharmacol Ther. 2012 Jul;92(1):14-5. doi: 10.1038/clpt.2012.70. 
PMID: 22713732

DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers.
Lee W, Ray R, Bergen AW, Swan GE, Thomas P, Tyndale RF, Benowitz NL, Lerman C, Conti DV.
Pharmacogenet Genomics. 2012 Jul;22(7):551-4. doi: 10.1097/FPC.0b013e3283539062.
PMID: 22495174

PharmGKB summary: very important pharmacogene information for CYP3A5.
Lamba J, Hebert JM, Schuetz EG, Klein TE, Altman RB.
Pharmacogenet Genomics. 2012 Jul;22(7):555-8. doi: 10.1097/FPC.0b013e328351d47f.
PMID: 22407409

*Editorial: current progress in Bioinformatics 2012.
Altman RB.
Brief Bioinform. 2012 Jul;13(4):393-4. doi: 10.1093/bib/bbs042. 
PMID: 22833494

CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel.
Hertz DL, Motsinger-Reif AA, Drobish A, Winham SJ, McLeod HL, Carey LA, Dees EC.
Breast Cancer Res Treat. 2012 Jul;134(1):401-10. doi: 10.1007/s10549-012-2054-0.
PMID: 22527101

June 2012Back to top

Exploratory planning and implementation of a pilot pharmacogenetic program in a community pharmacy.
O'Connor SK, Ferreri SP, Michaels NM, Greco AJ, Viera AJ, Faruki H, McLeod HL, Roederer MW.
Pharmacogenomics. 2012 Jun;13(8):955-62. doi: 10.2217/pgs.12.67.
PMID: 22676199

Advancing management of hypertension through pharmacogenomics.
Johnson JA.
Ann Med. 2012 Jun;44 Suppl 1:S17-22. doi: 10.3109/07853890.2011.653399. Review.
PMID: 22713143

Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.
Shroads AL, Langaee T, Coats BS, Kurtz TL, Bullock JR, Weithorn D, Gong Y, Wagner DA, Ostrov DA, Johnson JA, Stacpoole PW.
J Clin Pharmacol. 2012 Jun;52(6):837-49. 
PMID: 21642471

Pharmacogenetic association of the galanin receptor (GALR1) SNP rs2717162 with smoking cessation.
Gold AB, Wileyto EP, Lori A, Conti D, Cubells JF, Lerman C.
Neuropsychopharmacology. 2012 Jun;37(7):1683-8. doi: 10.1038/npp.2012.13.
PMID: 22373943

Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice.
Crowley JJ, Kim Y, Szatkiewicz JP, Pratt AL, Quackenbush CR, Adkins DE, van den Oord E, Bogue MA, Yang H, Wang W, Threadgill DW, de Villena FP, McLeod HL, Sullivan PF.
Mamm Genome. 2012 Jun;23(5-6):322-35.
PMID: 22207321

Translational bioinformatics: linking the molecular world to the clinical world.
Altman RB.
Clin Pharmacol Ther. 2012 Jun;91(6):994-1000. Review.
PMID: 22549287

Electronic medical records as a tool in clinical pharmacology: opportunities and challenges.
Roden DM, Xu H, Denny JC, Wilke RA.
Clin Pharmacol Ther. 2012 Jun;91(6):1083-86. Review.
PMID: 22534870

CYP2A6 genetic variation and dexmedetomidine disposition.
Kohli U, Pandharipande P, Muszkat M, Sofowora GG, Friedman EA, Scheinin M, Wood AJ, Ely EW, Tyndale RF, Choi L, Stein CM, Kurnik D.
Eur J Clin Pharmacol. 2012 Jun;68(6):937-42.
PMID: 22271297

Symptomatic Response to Antiarrhythmic Drug Therapy Is Modulated by a Common Single Nucleotide Polymorphism in Atrial Fibrillation.
Parvez B, Vaglio J, Rowan S, Muhammad R, Kucera G, Stubblefield T, Carter S, Roden D, Darbar D.
J Am Coll Cardiol. 2012 Jun 7. 
PMID: 22726630

Blocking SCN10A Channels in Heart Reduces Late Sodium Current and is Antiarrhythmic.
Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM.
Circ Res. 2012 Jun 20.
PMID: 22723299

Reduced Methadone Clearance During Aromatase Inhibition.
Lu WJ, Thong N, Flockhart DA.
J Clin Psychopharmacol. 2012 Jun 19. 
PMID: 22722506

PharmGKB summary: phenytoin pathway.
Thorn CF, Whirl-Carrillo M, Leeder JS, Klein TE, Altman RB.
Pharmacogenet Genomics. 2012 Jun;22(6):466-70. No abstract available.
PMID: 22569204

CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people.
J Binnington M, Zhu AZ, Renner CC, Lanier AP, Hatsukami DK, Benowitz NL, Tyndale RF.
Pharmacogenet Genomics. 2012 Jun;22(6):429-40.
PMID: 22569203

May 2012Back to top

Program in pharmacogenomics at the Ohio State University Medical Center.
Kitzmiller JP, Embi PJ, Manickam K, Sweet KM, Phelps MA, Jackson RD, Marsh CB, Sadee W.
Pharmacogenomics. 2012 May;13(7):751-6. doi: 10.2217/pgs.12.46. 
PMID: 22594506

Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.
Blanco JG, Sun CL, Landier W, Chen L, Esparza-Duran D, Leisenring W, Mays A, Friedman DL, Ginsberg JP, Hudson MM, Neglia JP, Oeffinger KC, Ritchey AK, Villaluna D, Relling MV, Bhatia S.
J Clin Oncol. 2012 May 1;30(13):1415-21.
PMID: 22124095

Institutional profile: program in pharmacogenomics at the ohio state university medical center.
Kitzmiller JP, Embi PJ, Manickam K, Sweet KM, Phelps MA, Jackson RD, Marsh CB, Sadee W.
Pharmacogenomics. 2012 May;13(7):751-6.
PMID: 22594506

FKBP5 as a Selection Biomarker for Gemcitabine and Akt Inhibitors in Treatment of Pancreatic Cancer.
Hou J, Wang L.
PLoS One. 2012;7(5):e36252. Epub 2012 May 9.
PMID: 22590527

Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project.
Pulley JM, Denny JC, Peterson JF, Bernard GR, Vnencak-Jones CL, Ramirez AH, Delaney JT, Bowton E, Brothers K, Johnson K, Crawford DC, Schildcrout J, Masys DR, Dilks HH, Wilke RA, Clayton EW, Shultz E, Laposata M, McPherson J, Jirjis JN, Roden DM.
Clin Pharmacol Ther. 2012 May 16. doi: 10.1038/clpt.2011.371. 
PMID: 22588608

Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D(3) function in human colon adenocarcinoma LS180 cells.
Zheng XE, Wang Z, Liao MZ, Lin YS, Shuhart MC, Schuetz EG, Thummel KE.
Biochem Pharmacol. 2012 May 3. 
PMID: 22562045

Clopidogrel: a case for indication-specific pharmacogenetics.
Johnson JA, Roden DM, Lesko LJ, Ashley E, Klein TE, Shuldiner AR.
Clin Pharmacol Ther. 2012 May;91(5):774-6. doi: 10.1038/clpt.2012.21.
PMID: 22513313

Genetic variation in CYP2A6 predicts neural reactivity to smoking cues as measured using fMRI.
Tang DW, Hello B, Mroziewicz M, Fellows LK, Tyndale RF, Dagher A.
Neuroimage. 2012 May 1;60(4):2136-43. 
PMID: 22342802

PharmGKB summary: caffeine pathway.
Thorn CF, Aklillu E, McDonagh EM, Klein TE, Altman RB.
Pharmacogenet Genomics. 2012 May;22(5):389-95. 
PMID: 22293536

April 2012Back to top

Cardiovascular pharmacogenomics: current status and future directions-report of a national heart, lung, and blood institute working group.
Musunuru K, Roden DM, Boineau R, Bristow MR, McCaffrey TA, Newton-Cheh C, Paltoo DN, Rosenberg Y, Wohlgemuth JG, Zineh I, Hasan AA.
J Am Heart Assoc. 2012 Apr;1(2):e000554. doi: 10.1161/JAHA.111.000554.
PMID: 23130127

Genetic tailoring of pharmacotherapy in heart failure: optimize the old, while we wait for something new.
Talameh JA, McLeod HL, Adams KF Jr, Patterson JH.
J Card Fail. 2012 Apr;18(4):338-49. Epub 2012 Feb 2. Review.
PMID: 22464776

Use of CYP2D6 genotyping in practice: tamoxifen dose adjustment.
Walko CM, McLeod H.
Pharmacogenomics. 2012 Apr;13(6):691-7. Review.
PMID: 22515611

Breast cancer pharmacogenomics: where we are going.
Newman WG, Flockhart D.
Pharmacogenomics. 2012 Apr;13(6):629-31.
PMID: 22515602

Paraoxonase 1 Q192R variant and clopidogrel efficacy: fact or fiction?
Lewis JP, Shuldiner AR.
Circ Cardiovasc Genet. 2012 Apr 1;5(2):153-5.
PMID: 22511706

Celecoxib pathways: pharmacokinetics and pharmacodynamics.
Gong L, Thorn CF, Bertagnolli MM, Grosser T, Altman RB, Klein TE.
Pharmacogenet Genomics. 2012 Apr;22(4):310-8.
PMID: 22336956

Novel tagging SNP rs1495741 and 2-SNPs (rs1041983 and rs1801280) yield a high prediction of the NAT2 genotype in HapMap samples.
He YJ, Shapero MH, McLeod HL.
Pharmacogenet Genomics. 2012 Apr;22(4):322-4. 
PMID: 22414877

Rat brain CYP2B-enzymatic activation of chlorpyrifos to the oxon mediates cholinergic neurotoxicity.
Khokhar JY, Tyndale RF.
Toxicol Sci. 2012 Apr;126(2):325-35.
PMID: 22287024

Germline pharmacogenomics in oncology: decoding the patient for targeting therapy.
O'Donnell PH, Ratain MJ.
Mol Oncol. 2012 Apr;6(2):251-9.
PMID: 22321460

Relationship between amounts of daily cigarette consumption and abdominal obesity moderated by CYP2A6 genotypes in Chinese male current smokers.
Liu T, David SP, Tyndale RF, Wang H, Yu XQ, Chen W, Zhou Q, Chen WQ.
Ann Behav Med. 2012 Apr;43(2):253-61.
PMID: 22160797

Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics.
Fridley BL, Jenkins GD, Batzler A, Wang L, Ji Y, Li F, Weinshilboum RM.
Pharmacogenomics J. 2012 Apr;12(2):105-10. doi: 10.1038/tpj.2010.83.
PMID: 21060324

PharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6.
McDonagh EM, Wassenaar C, David SP, Tyndale RF, Altman RB, Whirl-Carrillo M, Klein TE.
Pharmacogenet Genomics. 2012 Apr 26.
PMID: 22547082

Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours.
Kaye S, Aamdal S, Jones R, Freyer G, Pujade-Lauraine E, de Vries EG, Barriuso J, Sandhu S, Tan DS, Hartog V, Kuenen B, Ruijter R, Kristensen GB, Nyakas M, Barrett S, Burke W, Pietersma D, Stuart M, Emeribe U, Boven E.
Br J Cancer. 2012 Apr 24. doi: 10.1038/bjc.2012.158.
PMID: 22531637

Using ODIN for a PharmGKB revalidation experiment.
Rinaldi F, Clematide S, Garten Y, Whirl-Carrillo M, Gong L, Hebert JM, Sangkuhl K, Thorn CF, Klein TE, Altman RB.
Database (Oxford). 2012 Apr 23;2012:bas021. Print 2012.
PMID: 22529178

Interview: An interview with Pharmacogenomics for the breast cancer special focus issue.
Weinshilboum RM.
Pharmacogenomics. 2012 Apr;13(6):655-8.
PMID: 22515608

CYP2C19 genotype and cardiovascular events.
Shuldiner AR, Vesely MR, Fisch A.
JAMA. 2012 Apr 11;307(14):1482; author reply 1484-5. No abstract available.
PMID: 22496255

Critical Care Nurses' Role in Implementing the "ABCDE Bundle" Into Practice.
Balas MC, Vasilevskis EE, Burke WJ, Boehm L, Pun BT, Olsen KM, Peitz GJ, Ely EW.
Crit Care Nurse. 2012 Apr;32(2):35-47.
PMID: 22467611

Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics.
Abo R, Hebbring S, Ji Y, Zhu H, Zeng ZB, Batzler A, Jenkins GD, Biernacka J, Snyder K, Drews M, Fiehn O, Fridley B, Schaid D, Kamatani N, Nakamura Y, Kubo M, Mushiroda T, Kaddurah-Daouk R, Mrazek DA, Weinshilboum RM.
Pharmacogenet Genomics. 2012 Apr;22(4):247-53.
PMID: 22322242

March 2012Back to top

PharmGKB summary: very important pharmacogene information for G6PD.
McDonagh EM, Thorn CF, Bautista JM, Youngster I, Altman RB, Klein TE.
Pharmacogenet Genomics. 2012 Mar;22(3):219-28. doi: 10.1097/FPC.0b013e32834eb313.
PMID: 22237549

Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record.
Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC.
Pharmacogenomics. 2012 Mar;13(4):407-18. 
PMID: 22329724

Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes.
Philips S, Rae JM, Oesterreich S, Hayes DF, Stearns V, Henry NL, Storniolo AM, Flockhart DA, Skaar TC.
Front Pharmacol. 2012;3:54. Epub 2012 Mar 30.
PMID: 22479249

Data-driven prediction of drug effects and interactions.
Tatonetti NP, Ye PP, Daneshjou R, Altman RB.
Sci Transl Med. 2012 Mar 14;4(125):125ra31.
PMID: 22422992

Evidence of CYP3A allosterism in vivo: analysis of interaction between fluconazole and midazolam.
Yang J, Atkins WM, Isoherranen N, Paine MF, Thummel KE.
Clin Pharmacol Ther. 2012 Mar;91(3):442-9. doi: 10.1038/clpt.2011.178.
PMID: 22048224

Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers.
Michaud V, Ogburn E, Thong N, Aregbe AO, Quigg TC, Flockhart DA, Desta Z.
Clin Pharmacol Ther. 2012 Mar;91(3):475-82. doi: 10.1038/clpt.2011.249.
PMID: 22318618

Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide.
Duarte JD, Zineh I, Burkley B, Gong Y, Langaee TY, Turner ST, Chapman AB, Boerwinkle E, Gums JG, Cooper-Dehoff RM, Beitelshees AL, Bailey KR, Fillingim RB, Kone BC, Johnson JA.
J Transl Med. 2012 Mar 22;10(1):56. 
PMID: 22440088

Warfarin Pharmacogenetics: A Rising Tide for its Clinical Value.
Johnson JA.
Circulation. 2012 Mar 19.
PMID: 22431866

Personal omics profiling reveals dynamic molecular and medical phenotypes.
Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M.
Cell. 2012 Mar 16;148(6):1293-307.
PMID: 22424236

Genome-wide association and functional follow-up reveals new Loci for kidney function.
Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2), Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Koenig W, Illig T, Döring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Endlich K, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Metzger M, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki I, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman JC, Hayward C, Ridker P, Parsa A, Bochud M, Heid IM, Goessling W, Chasman DI, Kao WH, Fox CS.
PLoS Genet. 2012 Mar;8(3):e1002584. 
PMID: 22479191

Impact of Mifepristone, a Glucocorticoid/Progesterone Antagonist, on HDL Cholesterol, HDL Particle Concentration, and HDL Function.
Page ST, Krauss RM, Gross C, Ishida B, Heinecke JW, Tang C, Amory JK, Schaefer PM, Cox CJ, Kane J, Purnell JQ, Weinstein RL, Vaisar T.
J Clin Endocrinol Metab. 2012 Mar 7.
PMID: 22399518

Cholesteryl Ester Transfer Protein (CETP) Polymorphisms Affect mRNA Splicing, HDL Levels, and Sex-Dependent Cardiovascular Risk.
Papp AC, Pinsonneault JK, Wang D, Newman LC, Gong Y, Johnson JA, Pepine CJ, Kumari M, Hingorani AD, Talmud PJ, Shah S, Humphries SE, Sadee W.
PLoS One. 2012;7(3):e31930. Epub 2012 Mar 5.
PMID: 22403620

μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief.
Falcone M, Gold AB, Wileyto EP, Ray R, Ruparel K, Newberg A, Dubroff J, Logan J, Zubieta JK, Blendy JA, Lerman C.
Psychopharmacology (Berl). 2012 Mar 3.
PMID: 22389047

Modeling the 5-Fluorouracil Area Under the Curve Versus Dose Relationship to Develop a Pharmacokinetic Dosing Algorithm for Colorectal Cancer Patients Receiving FOLFOX6.
Kaldate RR, Haregewoin A, Grier CE, Hamilton SA, McLeod HL.
Oncologist. 2012 Mar 1.
PMID: 22382460

February 2012Back to top

Assessing the utility of whole genome amplified DNA as a template for DMET Plus array.
He YJ, Misher AD, Irvin W Jr, Motsinger-Reif A, McLeod HL, Hoskins JM.
Clin Chem Lab Med. 2012 Feb 14;50(8):1329-34. doi: 10.1515/cclm-2011-0747.
PMID: 22868796

Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response.
Ji Y, Biernacka J, Snyder K, Drews M, Pelleymounter LL, Colby C, Wang L, Mrazek DA, Weinshilboum RM.
Pharmacogenomics J. 2012 Feb;12(1):78-85. doi: 10.1038/tpj.2010.69.
PMID: 20877297

Genetic determinants of response to cardiovascular drugs.
Wells QS, Delaney JT, Roden DM.
Curr Opin Cardiol. 2012 Feb 29.
PMID: 22382501

Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network.
Fullerton SM, Wolf WA, Brothers KB, Clayton EW, Crawford DC, Denny JC, Greenland P, Koenig BA, Leppig KA, Lindor NM, McCarty CA, McGuire AL, McPeek Hinz ER, Mirel DB, Ramos EM, Ritchie MD, Smith ME, Waudby CJ, Burke W, Jarvik GP.
Genet Med. 2012 Feb 23. doi: 10.1038/gim.2012.15.
PMID: 22361898

Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer.
Li L, Schaid DJ, Fridley BL, Kalari KR, Jenkins GD, Abo RP, Batzler A, Moon I, Pelleymounter L, Eckloff BW, Wieben ED, Sun Z, Yang P, Wang L.
Pharmacogenet Genomics. 2012 Feb;22(2):105-16.
PMID: 22173087

PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 19.
Scott SA, Sangkuhl K, Shuldiner AR, Hulot JS, Thorn CF, Altman RB, Klein TE.
Pharmacogenet Genomics. 2012 Feb;22(2):159-65.
PMID: 22027650

Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.
Ciarimboli G, Lancaster CS, Schlatter E, Franke RM, Sprowl JA, Pavenstädt H, Massmann V, Guckel D, Mathijssen RH, Yang W, Pui CH, Relling MV, Herrmann E, Sparreboom A.
Clin Cancer Res. 2012 Feb 15;18(4):1101-8. Epub 2012 Jan 5.
PMID: 22223530

Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response.
Kreutz RP, Nystrom P, Kreutz Y, Miao J, Desta Z, Breall JA, Li L, Chiang C, Kovacs R, Flockhart DA, Jin Y.
Clin Pharmacol. 2012;4:13-20. Epub 2012 Feb 20.
PMID: 22427735

January 2012Back to top

Pharmacogenomics of adverse effects of anti-leukemic agents in children.
Relling MV.
J Pediatr Pharmacol Ther. 2012 Jan;17(1):7-11. doi: 10.5863/1551-6776-17.1.7.
PMID: 23118655

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.
Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, Alfredsson L, Padyukov L, Klareskog L, Worthington J, Siminovitch KA, Bae SC, Plenge RM, Gregersen PK, de Bakker PI.
Nat Genet. 2012 Jan 29;44(3):291-6. doi: 10.1038/ng.1076.
PMID: 22286218

Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.
Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV.
Genome Res. 2012 Jan;22(1):1-8.
PMID: 22147369

PharmGKB summary: very important pharmacogene information for CYP1A2.
Thorn CF, Aklillu E, Klein TE, Altman RB.
Pharmacogenet Genomics. 2012 Jan;22(1):73-7. 
PMID: 21989077

Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer.
Lu WJ, Desta Z, Flockhart DA.
Breast Cancer Res Treat. 2012 Jan;131(2):473-81.
PMID: 21390495

A genome-wide association search for type 2 diabetes genes in African Americans.
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP; DIAGRAM Consortium; MAGIC Investigators, Ferrara A, Lu L, Ziegler JT, Sale MM, Divers J, Shriner D, Adeyemo A, Rotimi CN, Ng MC, Langefeld CD, Freedman BI, Bowden DW, Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Boström KB, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, Soranzo N, Wheeler E, Glazer NL, Bouatia-Naji N, Mägi R, Randall J, Johnson T, Elliott P, Rybin D, Henneman P, Dehghan A, Hottenga JJ, Song K, Goel A, Egan JM, Lajunen T, Doney A, Kanoni S, Cavalcanti-Proença C, Kumari M, Timpson NJ, Zabena C, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Roccasecca RM, Pattou F, Sethupathy P, Ariyurek Y, Barter P, Beilby JP, Ben-Shlomo Y, Bergmann S, Bochud M, Bonnefond A, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Crisponi L, Day IN, de Geus EJ, Delplanque J, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Grundy S, Gwilliam R, Hallmans G, Hammond N, Han X, Hartikainen AL, Hayward C, Heath SC, Hercberg S, Hicks AA, Hillman DR, Hingorani AD, Hui J, Hung J, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Mukherjee S, Naitza S, Neville MJ, Oostra BA, Orrù M, Pakyz R, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Seedorf U, Sharp SJ, Shields B, Sijbrands EJ, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tanaka T, Tönjes A, Uitterlinden AG, van Dijk KW, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Ward KL, Watkins H, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, Borecki IB, Loos RJ, Meneton P, Magnusson PK, Nathan DM, Williams GH, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Lind L, Palmer LJ, Franks PW, Ebrahim S, Marmot M, Kao WH, Pramstaller PP, Wright AF, Stumvoll M, Hamsten A, Buchanan TA, Valle TT, Rotter JI, Siscovick DS, Penninx BW, Boomsma DI, Deloukas P, Spector TD, Ferrucci L, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Sladek R.
PLoS One. 2012;7(1):e29202. Epub 2012 Jan 4.
PMID: 22238593

Modeling drug exposure data in electronic medical records: an application to warfarin.
Liu M, Jiang M, Kawai VK, Stein CM, Roden DM, Denny JC, Xu H.
AMIA Annu Symp Proc. 2011;2011:815-23.
PMID: 22195139

Publications from 2011 

December 2011Back to top

Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.
Kirby BJ, Collier AC, Kharasch ED, Dixit V, Desai P, Whittington D, Thummel KE, Unadkat JD.
Drug Metab Dispos. 2011 Dec;39(12):2329-37. 
PMID: 21930825

Vitamin D in asthma and allergy: what next?
Weiss ST, Litonjua AA.
Eur Respir J. 2011 Dec;38(6):1255-7. No abstract available.
PMID: 22130761

PharmGKB summary: carbamazepine pathway.
Thorn CF, Leckband SG, Kelsoe J, Leeder JS, Müller DJ, Klein TE, Altman RB.
Pharmacogenet Genomics. 2011 Dec;21(12):906-10. No abstract available.
PMID: 21738081

University of Florida Clinical and Translational Science Institute: transformation and translation in personalized medicine.
Nelson DR, Conlon M, Baralt C, Johnson JA, Clare-Salzler MJ, Rawley-Payne M.
Clin Transl Sci. 2011 Dec;4(6):400-2. doi: 10.1111/j.1752-8062.2011.00348.x.
PMID: 22212220

November 2011Back to top

Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.
Gong IY, Schwarz UI, Crown N, Dresser GK, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Wells PS, Kim RB, Tirona RG.
PLoS One. 2011;6(11):e27808. Epub 2011 Nov 16.
PMID: 22114699

Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics.
Nordgren KK, Peng Y, Pelleymounter LL, Moon I, Abo R, Feng Q, Eckloff B, Yee VC, Wieben E, Weinshilboum RM.
Drug Metab Dispos. 2011 Nov;39(11):2135-47.
PMID: 21813468

Publications from 2009 

December 2009Back to top

Taxane pathway.
Oshiro C, Marsh S, McLeod H, Carrillo MW, Klein T, Altman R.
Pharmacogenet Genomics. 2009 Dec;19(12):979-83. 
PMID: 21151855

Pharmacogenomic trial design: use of a PK/PD model to explore warfarin dosing interventions through clinical trial simulation.
Salinger DH, Shen DD, Thummel K, Wittkowsky AK, Vicini P, Veenstra DL.
Pharmacogenet Genomics. 2009 Dec;19(12):965-71.
PMID: 19881396

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